Effects of genetic and nutritional factors on bone mineral density in young adults.

  • Authors:
    • Takemi Otsuki
    • Haruko Sakaguchi
    • Emiko Hatta
    • Tamayo Hatayama
    • Satomi Hatada
    • Yoshie Miura
    • Akiko Takata-Tomokuni
    • Fuminori Hyodoh
    • Tatsushi Tomomitsu
    • Masao Fukunaga
    • Hironobu Katsuyama
  • View Affiliations

  • Published online on: October 1, 2004     https://doi.org/10.3892/ijmm.14.4.669
  • Pages: 669-745
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Abstract

To estimate the genetic and dietary factors influencing bone mineral density (BMD) in young adults, a total of 53 healthy volunteers (HV) (age 20.89+/-1.34), from whom informed consent was obtained, answered a questionnaire on dietary factors and had DNA from peripheral blood mononuclear cells analyzed for single nucleotide polymorphisms (SNPs) for vitamin (Vit) D receptor (VDR), estrogen receptor alpha (ERalpha), interleukin 1 receptor antagonist (IL1RA), and apolipoprotein E (ApoE) genes. Daily intakes of Vit C, fiber, soybean and related foods, and green and yellow vegetables showed a correlation with % BMD. In addition, Vit B2 as well as Vit C, and vegetables were identified as important factors for BMD by Stepwise regression analysis. Among the SNPs analyzed, the B+ type of the VDR gene tended to be associated with a lower BMD, and pp type of the ER gene digested by the PvuII enzyme in females indicated a significantly lower BMD than that in males. In addition, these SNPs were also identified by factor analysis to be associated with BMD. These results suggested that a complex array of genetic factors, such as two or more SNPs or SNPs and gender, may be important to BMD.

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October 2004
Volume 14 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Otsuki T, Sakaguchi H, Hatta E, Hatayama T, Hatada S, Miura Y, Takata-Tomokuni A, Hyodoh F, Tomomitsu T, Fukunaga M, Fukunaga M, et al: Effects of genetic and nutritional factors on bone mineral density in young adults.. Int J Mol Med 14: 669-745, 2004
APA
Otsuki, T., Sakaguchi, H., Hatta, E., Hatayama, T., Hatada, S., Miura, Y. ... Katsuyama, H. (2004). Effects of genetic and nutritional factors on bone mineral density in young adults.. International Journal of Molecular Medicine, 14, 669-745. https://doi.org/10.3892/ijmm.14.4.669
MLA
Otsuki, T., Sakaguchi, H., Hatta, E., Hatayama, T., Hatada, S., Miura, Y., Takata-Tomokuni, A., Hyodoh, F., Tomomitsu, T., Fukunaga, M., Katsuyama, H."Effects of genetic and nutritional factors on bone mineral density in young adults.". International Journal of Molecular Medicine 14.4 (2004): 669-745.
Chicago
Otsuki, T., Sakaguchi, H., Hatta, E., Hatayama, T., Hatada, S., Miura, Y., Takata-Tomokuni, A., Hyodoh, F., Tomomitsu, T., Fukunaga, M., Katsuyama, H."Effects of genetic and nutritional factors on bone mineral density in young adults.". International Journal of Molecular Medicine 14, no. 4 (2004): 669-745. https://doi.org/10.3892/ijmm.14.4.669