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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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January 2005 Volume 15 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Quantitative and qualitative alterations of intestinal mucins in BioBreeding rats

  • Authors:
    • Philippe Courtois
    • Cedric Jurysta
    • Abdullah Sener
    • Fraser W. Scott
    • Willy J. Malaisse

  • View Affiliations / Copyright

    Affiliations: Laboratory of Experimental Hormonology, Brussels Free University, B-1070 Brussels, Belgium
  • Pages: 105-108
    |
    Published online on: January 1, 2005
       https://doi.org/10.3892/ijmm.15.1.105
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Abstract

In diabetes-prone BioBreeding rats, an enteropathy often precedes the onset of auto-immune insulitis. The present study draws attention to quantitative and qualitative alterations of intestinal mucins in this animal model of type 1 diabetes mellitus. Male and female diabetes-resistant (BBc) and diabetes-prone (BBdp) BioBreeding rats fed, from one to two weeks after weaning onwards, either a plant-based diabetes-promoting diet (NTP) or a hydrolysed casein diabetes-protective diet (HC), were sacrificed at 11-14 weeks of age. Proteins and total mucins, as well as acid and neutral mucins, were measured in a segment of the intestinal tract, located 25-30 cm below the pylorus. No significant difference between BBc and BBdp rats was found when fed the HC diet. However, the NTP diet lowered both total and neutral mucins, whilst failing to affect significantly acidic mucins. The effects of the NTP diet were more pronounced in BBdp rats than in BBc rats. It is speculated that the quantitative and qualitative changes evoked by the NTP diet in BBdp rats may play a role in the alteration of gut permeability found under the same experimental conditions.

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Copy and paste a formatted citation
Spandidos Publications style
Courtois P, Jurysta C, Sener A, Scott FW and Malaisse WJ: Quantitative and qualitative alterations of intestinal mucins in BioBreeding rats. Int J Mol Med 15: 105-108, 2005.
APA
Courtois, P., Jurysta, C., Sener, A., Scott, F.W., & Malaisse, W.J. (2005). Quantitative and qualitative alterations of intestinal mucins in BioBreeding rats. International Journal of Molecular Medicine, 15, 105-108. https://doi.org/10.3892/ijmm.15.1.105
MLA
Courtois, P., Jurysta, C., Sener, A., Scott, F. W., Malaisse, W. J."Quantitative and qualitative alterations of intestinal mucins in BioBreeding rats". International Journal of Molecular Medicine 15.1 (2005): 105-108.
Chicago
Courtois, P., Jurysta, C., Sener, A., Scott, F. W., Malaisse, W. J."Quantitative and qualitative alterations of intestinal mucins in BioBreeding rats". International Journal of Molecular Medicine 15, no. 1 (2005): 105-108. https://doi.org/10.3892/ijmm.15.1.105
Copy and paste a formatted citation
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Spandidos Publications style
Courtois P, Jurysta C, Sener A, Scott FW and Malaisse WJ: Quantitative and qualitative alterations of intestinal mucins in BioBreeding rats. Int J Mol Med 15: 105-108, 2005.
APA
Courtois, P., Jurysta, C., Sener, A., Scott, F.W., & Malaisse, W.J. (2005). Quantitative and qualitative alterations of intestinal mucins in BioBreeding rats. International Journal of Molecular Medicine, 15, 105-108. https://doi.org/10.3892/ijmm.15.1.105
MLA
Courtois, P., Jurysta, C., Sener, A., Scott, F. W., Malaisse, W. J."Quantitative and qualitative alterations of intestinal mucins in BioBreeding rats". International Journal of Molecular Medicine 15.1 (2005): 105-108.
Chicago
Courtois, P., Jurysta, C., Sener, A., Scott, F. W., Malaisse, W. J."Quantitative and qualitative alterations of intestinal mucins in BioBreeding rats". International Journal of Molecular Medicine 15, no. 1 (2005): 105-108. https://doi.org/10.3892/ijmm.15.1.105
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