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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2005 Volume 16 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Frequent apoptosis in placental villi from pregnancies complicated with intrauterine growth restriction and without maternal symptoms

  • Authors:
    • Hisae Endo
    • Aikou Okamoto
    • Kyosuke Yamada
    • Takashi Nikaido
    • Tadao Tanaka

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan
  • Pages: 79-84
    |
    Published online on: July 1, 2005
       https://doi.org/10.3892/ijmm.16.1.79
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Abstract

The objective of this study was to examine the incidence of apoptosis in placentas of intrauterine growth restriction (IUGR) without maternal disease. We focused on cases of IUGR with both unknown causes and no maternal complications. In addition, apoptosis of IUGR placentas was correlated with the expression of proteins involved in apoptosis and cell turnover. The term placentas were obtained from 16 normal and 10 IUGR pregnancies without maternal symptoms. We analyzed the localization of apoptosis and counted >2000 nuclei by TUNEL assay and transmission electron microscopy in placentas from normal and IUGR cases. We found the incidence of apoptosis to be significantly higher in placentas with IUGR (2.98%) than in normal placentas (1.46%) by TUNEL assay (p=0.03). In addition, immunohistochemical analysis was performed to examine the expression of proteins related to apoptosis and general cell turnover, including the active form of caspase-3, Bax, p53, and Ki-67. Expression of the active form of caspase-3 was significantly higher in IUGR than in a normal pregnancy (p=0.03). These results suggest that enhanced execution of apoptosis through caspase-3 may play a role in IUGR without maternal symptoms.

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Copy and paste a formatted citation
Spandidos Publications style
Endo H, Okamoto A, Yamada K, Nikaido T and Tanaka T: Frequent apoptosis in placental villi from pregnancies complicated with intrauterine growth restriction and without maternal symptoms. Int J Mol Med 16: 79-84, 2005.
APA
Endo, H., Okamoto, A., Yamada, K., Nikaido, T., & Tanaka, T. (2005). Frequent apoptosis in placental villi from pregnancies complicated with intrauterine growth restriction and without maternal symptoms. International Journal of Molecular Medicine, 16, 79-84. https://doi.org/10.3892/ijmm.16.1.79
MLA
Endo, H., Okamoto, A., Yamada, K., Nikaido, T., Tanaka, T."Frequent apoptosis in placental villi from pregnancies complicated with intrauterine growth restriction and without maternal symptoms". International Journal of Molecular Medicine 16.1 (2005): 79-84.
Chicago
Endo, H., Okamoto, A., Yamada, K., Nikaido, T., Tanaka, T."Frequent apoptosis in placental villi from pregnancies complicated with intrauterine growth restriction and without maternal symptoms". International Journal of Molecular Medicine 16, no. 1 (2005): 79-84. https://doi.org/10.3892/ijmm.16.1.79
Copy and paste a formatted citation
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Spandidos Publications style
Endo H, Okamoto A, Yamada K, Nikaido T and Tanaka T: Frequent apoptosis in placental villi from pregnancies complicated with intrauterine growth restriction and without maternal symptoms. Int J Mol Med 16: 79-84, 2005.
APA
Endo, H., Okamoto, A., Yamada, K., Nikaido, T., & Tanaka, T. (2005). Frequent apoptosis in placental villi from pregnancies complicated with intrauterine growth restriction and without maternal symptoms. International Journal of Molecular Medicine, 16, 79-84. https://doi.org/10.3892/ijmm.16.1.79
MLA
Endo, H., Okamoto, A., Yamada, K., Nikaido, T., Tanaka, T."Frequent apoptosis in placental villi from pregnancies complicated with intrauterine growth restriction and without maternal symptoms". International Journal of Molecular Medicine 16.1 (2005): 79-84.
Chicago
Endo, H., Okamoto, A., Yamada, K., Nikaido, T., Tanaka, T."Frequent apoptosis in placental villi from pregnancies complicated with intrauterine growth restriction and without maternal symptoms". International Journal of Molecular Medicine 16, no. 1 (2005): 79-84. https://doi.org/10.3892/ijmm.16.1.79
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