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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2005 Volume 16 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53

  • Authors:
    • Xiaolong Yin
    • Dennis R. Warner
    • Emily A. Roberts
    • M. Michele Pisano
    • Robert M. Greene

  • View Affiliations / Copyright

    Affiliations: Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, Birth Defects Center, 501 S. Preston Street, Suite 301, Louisville, KY 40292, USA
  • Pages: 251-256
    |
    Published online on: August 1, 2005
       https://doi.org/10.3892/ijmm.16.2.251
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Abstract

cAMP response element-binding protein (CREB)-binding protein (CBP) is a multifunctional transcriptional co-activator that plays important roles in cell proliferation and differentiation. CBP is expressed in murine embryonic orofacial tissue and is developmentally regulated. To identify nuclear factors associating with CBP in developing orofacial tissue, a yeast two-hybrid screen of a cDNA library derived from embryonic orofacial tissue from gestational days 11-13 mouse embryos was conducted. The carboxy terminal region of CBP (including the C/H3 region) was utilized as a bait. C53, a 57 kDa protein known to bind to the p25 activator of cyclin-dependent kinase 5, was identified as a novel binding partner of CBP. The association of C53 with CBP was confirmed in vitro by glutathione S-transferase pull-down assays, and in vivo by co-immunoprecipitation. Reporter assays demonstrated that C53 had little effect on CBP mediated transcriptional activation. These results identify C53 as a novel binding partner for CBP. Recent research on presenilin-loss induced neurodegeneration demonstrated decreased expression of CBP and increased levels of the Cdk5 activator p25, both C53 binding proteins, suggesting that C53 might play a role in regulating neuronal proliferation, migration and/or differentiation in embryonic development.

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Copy and paste a formatted citation
Spandidos Publications style
Yin X, Warner DR, Roberts EA, Pisano MM and Greene RM: Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53 . Int J Mol Med 16: 251-256, 2005.
APA
Yin, X., Warner, D.R., Roberts, E.A., Pisano, M.M., & Greene, R.M. (2005). Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53 . International Journal of Molecular Medicine, 16, 251-256. https://doi.org/10.3892/ijmm.16.2.251
MLA
Yin, X., Warner, D. R., Roberts, E. A., Pisano, M. M., Greene, R. M."Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53 ". International Journal of Molecular Medicine 16.2 (2005): 251-256.
Chicago
Yin, X., Warner, D. R., Roberts, E. A., Pisano, M. M., Greene, R. M."Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53 ". International Journal of Molecular Medicine 16, no. 2 (2005): 251-256. https://doi.org/10.3892/ijmm.16.2.251
Copy and paste a formatted citation
x
Spandidos Publications style
Yin X, Warner DR, Roberts EA, Pisano MM and Greene RM: Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53 . Int J Mol Med 16: 251-256, 2005.
APA
Yin, X., Warner, D.R., Roberts, E.A., Pisano, M.M., & Greene, R.M. (2005). Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53 . International Journal of Molecular Medicine, 16, 251-256. https://doi.org/10.3892/ijmm.16.2.251
MLA
Yin, X., Warner, D. R., Roberts, E. A., Pisano, M. M., Greene, R. M."Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53 ". International Journal of Molecular Medicine 16.2 (2005): 251-256.
Chicago
Yin, X., Warner, D. R., Roberts, E. A., Pisano, M. M., Greene, R. M."Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53 ". International Journal of Molecular Medicine 16, no. 2 (2005): 251-256. https://doi.org/10.3892/ijmm.16.2.251
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