Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house dust mite allergen in mice

Inoue,Ken-Ichiro; Takano,Hirohisa; Shiga,Akira; Fujita,Yoji; Makino,Hiroaki; Yanagisawa,Rie; Ichinose,Takamichi; Kato,Yoji; Yamada,Tomozo; Yoshikawa,Toshikazu

doi:10.3892/ijmm.16.2.315

August 2005 Volume 16 Issue 2

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August 2005 Volume 16 Issue 2

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Article

Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house dust mite allergen in mice

Authors:
- Ken-Ichiro Inoue
- Hirohisa Takano
- Akira Shiga
- Yoji Fujita
- Hiroaki Makino
- Rie Yanagisawa
- Takamichi Ichinose
- Yoji Kato
- Tomozo Yamada
- Toshikazu Yoshikawa
View Affiliations / Copyright

Affiliations: Inhalation Toxicology & Pathophysiology Research Team, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba 305-8506, Japan
Pages: 315-319
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Published online on: August 1, 2005

https://doi.org/10.3892/ijmm.16.2.315
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Abstract

Perilla leaf extract is known to have anti-inflammatory properties. Recently, we have demonstrated that rosmarinic acid, a polyphenolic liquid component in perilla, inhibits the allergic airway inflammation induced by house dust mites (HDMs) in vivo. The purpose of this study was to evaluate the effects of intratracheal (i.t.) exposure to volatile constituents of a rosemary extract (VR), gaseous components in perilla, on a murine model of allergic asthma induced by HDM. C3H/HeN mice were treated 7 times weekly with i.t. exposure. The HDM allergen challenge elicited a pulmonary eosinophilic inflammation accompanied by an increase in the lung expression of interleukin (IL)-5, IL-13, and eotaxin. VR inhibited increases in the number of eosinophils, neutrophils, and mononuclear cells around the airways and those in the bronchoalveolar lavage fluid. VR exposure also significantly suppressed the expression of IL-13 enhanced by HDM allergen. These results suggest that i.t. exposure to VR can, at least partially, prevent allergic airway inflammation induced by HDM. The preventive effect is associated with inhibition of the enhanced local expression of IL-13.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house dust mite allergen in mice

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Abstract

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