Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house dust mite allergen in mice

  • Authors:
    • Ken-Ichiro Inoue
    • Hirohisa Takano
    • Akira Shiga
    • Yoji Fujita
    • Hiroaki Makino
    • Rie Yanagisawa
    • Takamichi Ichinose
    • Yoji Kato
    • Tomozo Yamada
    • Toshikazu Yoshikawa
  • View Affiliations

  • Published online on: August 1, 2005     https://doi.org/10.3892/ijmm.16.2.315
  • Pages: 315-319
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Perilla leaf extract is known to have anti-inflammatory properties. Recently, we have demonstrated that rosmarinic acid, a polyphenolic liquid component in perilla, inhibits the allergic airway inflammation induced by house dust mites (HDMs) in vivo. The purpose of this study was to evaluate the effects of intratracheal (i.t.) exposure to volatile constituents of a rosemary extract (VR), gaseous components in perilla, on a murine model of allergic asthma induced by HDM. C3H/HeN mice were treated 7 times weekly with i.t. exposure. The HDM allergen challenge elicited a pulmonary eosinophilic inflammation accompanied by an increase in the lung expression of interleukin (IL)-5, IL-13, and eotaxin. VR inhibited increases in the number of eosinophils, neutrophils, and mononuclear cells around the airways and those in the bronchoalveolar lavage fluid. VR exposure also significantly suppressed the expression of IL-13 enhanced by HDM allergen. These results suggest that i.t. exposure to VR can, at least partially, prevent allergic airway inflammation induced by HDM. The preventive effect is associated with inhibition of the enhanced local expression of IL-13.

Related Articles

Journal Cover

August 2005
Volume 16 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Inoue K, Takano H, Shiga A, Fujita Y, Makino H, Yanagisawa R, Ichinose T, Kato Y, Yamada T, Yoshikawa T, Yoshikawa T, et al: Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house dust mite allergen in mice. Int J Mol Med 16: 315-319, 2005
APA
Inoue, K., Takano, H., Shiga, A., Fujita, Y., Makino, H., Yanagisawa, R. ... Yoshikawa, T. (2005). Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house dust mite allergen in mice. International Journal of Molecular Medicine, 16, 315-319. https://doi.org/10.3892/ijmm.16.2.315
MLA
Inoue, K., Takano, H., Shiga, A., Fujita, Y., Makino, H., Yanagisawa, R., Ichinose, T., Kato, Y., Yamada, T., Yoshikawa, T."Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house dust mite allergen in mice". International Journal of Molecular Medicine 16.2 (2005): 315-319.
Chicago
Inoue, K., Takano, H., Shiga, A., Fujita, Y., Makino, H., Yanagisawa, R., Ichinose, T., Kato, Y., Yamada, T., Yoshikawa, T."Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house dust mite allergen in mice". International Journal of Molecular Medicine 16, no. 2 (2005): 315-319. https://doi.org/10.3892/ijmm.16.2.315