A very short segment of the murine Ret promoter contains elements sensitive to in vitro neural cell differentiation

  • Authors:
    • Paola Zordan
    • Roberto Ravazzolo
    • Renata Bocciardi
  • View Affiliations

  • Published online on: August 1, 2005     https://doi.org/10.3892/ijmm.16.2.325
  • Pages: 325-331
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Regulation of the murine Ret gene has only been partially studied, specifically cis-acting promoter elements and related transcription factors, although in vivo experiments have shown the ability of Ret 5' flanking sequences to drive expression of transgenic reporter genes. This work describes the characterization of a 387-bp fragment of the Ret 5' flanking sequence with the ability to activate expression of the LacZ gene in transfected cells, in which SP1 recognition elements played a fundamental role. Using P19 teratocarcinoma cells differentiated by retinoic acid treatment, we observed an induction of Ret mRNA accompanied by a decrease of SP1 binding due to its proteolytic cleavage.

Related Articles

Journal Cover

August 2005
Volume 16 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zordan P, Ravazzolo R and Bocciardi R: A very short segment of the murine Ret promoter contains elements sensitive to in vitro neural cell differentiation. Int J Mol Med 16: 325-331, 2005
APA
Zordan, P., Ravazzolo, R., & Bocciardi, R. (2005). A very short segment of the murine Ret promoter contains elements sensitive to in vitro neural cell differentiation. International Journal of Molecular Medicine, 16, 325-331. https://doi.org/10.3892/ijmm.16.2.325
MLA
Zordan, P., Ravazzolo, R., Bocciardi, R."A very short segment of the murine Ret promoter contains elements sensitive to in vitro neural cell differentiation". International Journal of Molecular Medicine 16.2 (2005): 325-331.
Chicago
Zordan, P., Ravazzolo, R., Bocciardi, R."A very short segment of the murine Ret promoter contains elements sensitive to in vitro neural cell differentiation". International Journal of Molecular Medicine 16, no. 2 (2005): 325-331. https://doi.org/10.3892/ijmm.16.2.325