Expression of Y-Box binding protein-1 following hypericin-mediated photodynamic therapy in well-differentiated nasopharyngeal cancer in vivo

  • Authors:
    • Hong-Yan Du
    • Malini Olivo
    • Ying-Jie Chen
    • George Yip
    • Puay-Hoon Tan
    • Ken Matsumoto
    • Masafumi Tsujimoto
    • Boon-Huat Bay
  • View Affiliations

  • Published online on: November 1, 2005     https://doi.org/10.3892/ijmm.16.5.865
  • Pages: 865-868
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Abstract

The Y-Box binding protein, YB-1, belongs to a group in the DNA and RNA binding protein family. YB-1 is known to be expressed in a number of different cancers and reported to protect cells against DNA-damaging agents such as ultraviolet light. The purpose of this study was to determine if YB-1 levels are altered in photodynamic therapy (PDT)-treated nasopharyngeal cancer (NPC) cells. In this report, we show for the first time that YB-1 is expressed at both the mRNA and protein levels in well-differentiated NPC in vivo. YB-1 mRNA expression in tumor tissues from a murine well-differentiated HK1/NPC model showed no significant difference in mRNA levels following hypericin-PDT. Localization of the YB-1 protein by immuno-histochemistry revealed the presence of cytoplasmic YB-1 in the more mature and better differentiated cells of the untreated group, as well as cells that survived PDT treatment. Expression of the YB-1 protein may possibly influence the cellular stress response to hypericin-PDT and protect the cells from phototoxicity.

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November 2005
Volume 16 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Du H, Olivo M, Chen Y, Yip G, Tan P, Matsumoto K, Tsujimoto M and Bay B: Expression of Y-Box binding protein-1 following hypericin-mediated photodynamic therapy in well-differentiated nasopharyngeal cancer in vivo. Int J Mol Med 16: 865-868, 2005
APA
Du, H., Olivo, M., Chen, Y., Yip, G., Tan, P., Matsumoto, K. ... Bay, B. (2005). Expression of Y-Box binding protein-1 following hypericin-mediated photodynamic therapy in well-differentiated nasopharyngeal cancer in vivo. International Journal of Molecular Medicine, 16, 865-868. https://doi.org/10.3892/ijmm.16.5.865
MLA
Du, H., Olivo, M., Chen, Y., Yip, G., Tan, P., Matsumoto, K., Tsujimoto, M., Bay, B."Expression of Y-Box binding protein-1 following hypericin-mediated photodynamic therapy in well-differentiated nasopharyngeal cancer in vivo". International Journal of Molecular Medicine 16.5 (2005): 865-868.
Chicago
Du, H., Olivo, M., Chen, Y., Yip, G., Tan, P., Matsumoto, K., Tsujimoto, M., Bay, B."Expression of Y-Box binding protein-1 following hypericin-mediated photodynamic therapy in well-differentiated nasopharyngeal cancer in vivo". International Journal of Molecular Medicine 16, no. 5 (2005): 865-868. https://doi.org/10.3892/ijmm.16.5.865