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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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December 2005 Volume 16 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2005 Volume 16 Issue 6

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Article

Identification of regions of α-catenin required for desmosome organization in epithelial cells

  • Authors:
    • Tamotsu Taniguchi
    • Mutsumi Miyazaki
    • Yayoi Miyashita
    • Terukatsu Arima
    • Masayuki Ozawa

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan
  • Pages: 1003-1008
    |
    Published online on: December 1, 2005
       https://doi.org/10.3892/ijmm.16.6.1003
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Abstract

α-catenin, a cadherin-associated protein, links cadherin/β-catenin and cadherin/plakoglobin complexes to the actin cytoskeleton. This protein is required for the function of cadherins, cell adhesion molecules. We transfected an α-catenin-deficient colon carcinoma line, which cannot organize desmosomes, with a series of α-catenin mutant constructs. We examined the formation of desmosomes in these cells by immunofluorescence staining using anti-desmoglein and anti-desmoplakin antibodies. The results demonstrated that either the middle or the carboxy-terminal region of α-catenin was required for desmosome formation. Immunoblot analysis revealed that the amounts of desmoglein and desmoplakin did not differ significantly between cells that were capable of forming desmosomes and those that failed to form desmosomes. Cell surface biotinylation revealed that desmoglein was retained intracellularly in cells that could not organize desmosomes. The internal domain binds vinculin and α-actinin, actin-binding proteins, while the carboxy-terminal domain has the ability to bind and bundle actin filaments. These results indicate that the interaction of α-catenin and actin functions in the assembly of desmosomes in epithelial cells.

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Copy and paste a formatted citation
Spandidos Publications style
Taniguchi T, Miyazaki M, Miyashita Y, Arima T and Ozawa M: Identification of regions of α-catenin required for desmosome organization in epithelial cells. Int J Mol Med 16: 1003-1008, 2005.
APA
Taniguchi, T., Miyazaki, M., Miyashita, Y., Arima, T., & Ozawa, M. (2005). Identification of regions of α-catenin required for desmosome organization in epithelial cells. International Journal of Molecular Medicine, 16, 1003-1008. https://doi.org/10.3892/ijmm.16.6.1003
MLA
Taniguchi, T., Miyazaki, M., Miyashita, Y., Arima, T., Ozawa, M."Identification of regions of α-catenin required for desmosome organization in epithelial cells". International Journal of Molecular Medicine 16.6 (2005): 1003-1008.
Chicago
Taniguchi, T., Miyazaki, M., Miyashita, Y., Arima, T., Ozawa, M."Identification of regions of α-catenin required for desmosome organization in epithelial cells". International Journal of Molecular Medicine 16, no. 6 (2005): 1003-1008. https://doi.org/10.3892/ijmm.16.6.1003
Copy and paste a formatted citation
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Spandidos Publications style
Taniguchi T, Miyazaki M, Miyashita Y, Arima T and Ozawa M: Identification of regions of α-catenin required for desmosome organization in epithelial cells. Int J Mol Med 16: 1003-1008, 2005.
APA
Taniguchi, T., Miyazaki, M., Miyashita, Y., Arima, T., & Ozawa, M. (2005). Identification of regions of α-catenin required for desmosome organization in epithelial cells. International Journal of Molecular Medicine, 16, 1003-1008. https://doi.org/10.3892/ijmm.16.6.1003
MLA
Taniguchi, T., Miyazaki, M., Miyashita, Y., Arima, T., Ozawa, M."Identification of regions of α-catenin required for desmosome organization in epithelial cells". International Journal of Molecular Medicine 16.6 (2005): 1003-1008.
Chicago
Taniguchi, T., Miyazaki, M., Miyashita, Y., Arima, T., Ozawa, M."Identification of regions of α-catenin required for desmosome organization in epithelial cells". International Journal of Molecular Medicine 16, no. 6 (2005): 1003-1008. https://doi.org/10.3892/ijmm.16.6.1003
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