Neurite extension of DRG neurons by gicerin expression is enhanced by nerve growth factor

  • Authors:
    • Satoshi Hiroi
    • Eiichi Taira
    • Kazushige Ogawa
    • Yasuhiro Tsukamoto
  • View Affiliations

  • Published online on: December 1, 2005     https://doi.org/10.3892/ijmm.16.6.1009
  • Pages: 1009-1014
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Abstract

Gicerin, a cell adhesion molecule, is expressed in dorsal root ganglion (DRG) and sciatic nerves during chick development. This molecule re-appears in these tissues after an injury to the sciatic nerve. In the present study, we investigated the expression of nerve growth factor (NGF) in the regenerating sciatic nerve of chicks and the effects of NGF on the expression and neurite activities of gicerin in DRG. In the sciatic nerve after a crush injury, the expression of NGF and gicerin increased in the Schwann cells and in the nerve fibers, respectively. NGF promoted the neurite projections from in vitro DRG on the gicerin ligands, which were inhibited by anti-NGF antibody. The gicerin mRNA expression increased in the DRG with NGF, which was inhibited by the co-incubation with anti-NGF antibody. These results indicate that NGF might therefore enhance the expression of gicerin in DRG, thereby promoting the gicerin-dependent neurite extension during sciatic nerve regeneration.

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December 2005
Volume 16 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Hiroi S, Taira E, Ogawa K and Tsukamoto Y: Neurite extension of DRG neurons by gicerin expression is enhanced by nerve growth factor. Int J Mol Med 16: 1009-1014, 2005
APA
Hiroi, S., Taira, E., Ogawa, K., & Tsukamoto, Y. (2005). Neurite extension of DRG neurons by gicerin expression is enhanced by nerve growth factor. International Journal of Molecular Medicine, 16, 1009-1014. https://doi.org/10.3892/ijmm.16.6.1009
MLA
Hiroi, S., Taira, E., Ogawa, K., Tsukamoto, Y."Neurite extension of DRG neurons by gicerin expression is enhanced by nerve growth factor". International Journal of Molecular Medicine 16.6 (2005): 1009-1014.
Chicago
Hiroi, S., Taira, E., Ogawa, K., Tsukamoto, Y."Neurite extension of DRG neurons by gicerin expression is enhanced by nerve growth factor". International Journal of Molecular Medicine 16, no. 6 (2005): 1009-1014. https://doi.org/10.3892/ijmm.16.6.1009