Up-regulation of metallothionein isoforms in keloid keratinocytes

  • Authors:
    • D. Lim
    • T. T. Phan
    • G. W. Yip
    • B. H. Bay
  • View Affiliations

  • Published online on: February 1, 2006     https://doi.org/10.3892/ijmm.17.2.385
  • Pages: 385-389
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Abstract

Keloids are proliferative growths of dermal collagen, usually resulting from excessive tissue response during wound healing. There is evidence that keratinocytes may promote keloidogenesis via epithelial-mesenchymal interactions. Metallothioneins (MTs) are known to be involved in the fundamental cellular processes of growth and apoptosis. In this study, we evaluated the expression of MT isoforms in normal and keloid keratinocytes. The expression patterns of ten functional MT isoforms were assessed using real-time RT-PCR in primary cultures of normal and keloid keratinocytes. The MT-2A isoform was the most abundant MT isoform in both normal and keloid keratinocytes while the MT-1B isoform was absent. There was a significant increase in the mRNA expression of four MT isoforms, viz. MT-1A, 1E, 1F and 2A in keloid keratinocytes as compared to normal keratinocytes. Up-regulation of MT-1A, 1E, 1F and 2A isoforms may play a part in the development of keloids by paracrine signaling.

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February 2006
Volume 17 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Lim D, Phan TT, Yip GW and Bay BH: Up-regulation of metallothionein isoforms in keloid keratinocytes. Int J Mol Med 17: 385-389, 2006
APA
Lim, D., Phan, T.T., Yip, G.W., & Bay, B.H. (2006). Up-regulation of metallothionein isoforms in keloid keratinocytes. International Journal of Molecular Medicine, 17, 385-389. https://doi.org/10.3892/ijmm.17.2.385
MLA
Lim, D., Phan, T. T., Yip, G. W., Bay, B. H."Up-regulation of metallothionein isoforms in keloid keratinocytes". International Journal of Molecular Medicine 17.2 (2006): 385-389.
Chicago
Lim, D., Phan, T. T., Yip, G. W., Bay, B. H."Up-regulation of metallothionein isoforms in keloid keratinocytes". International Journal of Molecular Medicine 17, no. 2 (2006): 385-389. https://doi.org/10.3892/ijmm.17.2.385