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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May 2006 Volume 17 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2006 Volume 17 Issue 5

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Article

Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease

  • Authors:
    • Heike Kölsch
    • Dieter Lütjohann
    • Frank Jessen
    • Klaus Von Bergmann
    • Sandra Schmitz
    • Horst Urbach
    • Wolfgang Maier
    • Reinhard Heun

  • View Affiliations / Copyright

    Affiliations: Department of Psychiatry, University of Bonn, 53105 Bonn, Germany. heike.koelsch@ukb.uni-bonn.de
  • Pages: 791-794
    |
    Published online on: May 1, 2006
       https://doi.org/10.3892/ijmm.17.5.791
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Abstract

The ATP-binding cassette transporter A1 (ABCA1) mediates reverse cholesterol transport, polymorphisms have been shown to influence the levels of cholesterol and of HDL and the risk of coronary artery disease. Since altered cholesterol metabolism is also involved in Alzheimer's disease (AD), the effects of two ABCA1 polymorphisms (G-395C promoter polymorphism (rs 2246293) and exonic R219K) on the risk of AD in 241 AD patients and 294 non- demented controls, and on CSF cholesterol and 24S-hydroxycholesterol in 74 AD patients and 42 non-demented controls were investigated. None of the investigated ABCA1 polymorphisms influenced the risk of AD. However, the ABCA1 G-395C polymorphism influenced CSF levels of 24S-hydroxycholesterol, but not of cholesterol, whereas the R219K influenced neither CSF levels of 24S-hydroxycholesterol nor cholesterol. Our data support the observation that ABCA1 polymorphisms influence cholesterol metabolism of the brain, but might not act as a major risk factor in AD.

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Copy and paste a formatted citation
Spandidos Publications style
Kölsch H, Lütjohann D, Jessen F, Von Bergmann K, Schmitz S, Urbach H, Maier W and Heun R: Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease. Int J Mol Med 17: 791-794, 2006.
APA
Kölsch, H., Lütjohann, D., Jessen, F., Von Bergmann, K., Schmitz, S., Urbach, H. ... Heun, R. (2006). Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease. International Journal of Molecular Medicine, 17, 791-794. https://doi.org/10.3892/ijmm.17.5.791
MLA
Kölsch, H., Lütjohann, D., Jessen, F., Von Bergmann, K., Schmitz, S., Urbach, H., Maier, W., Heun, R."Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease". International Journal of Molecular Medicine 17.5 (2006): 791-794.
Chicago
Kölsch, H., Lütjohann, D., Jessen, F., Von Bergmann, K., Schmitz, S., Urbach, H., Maier, W., Heun, R."Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease". International Journal of Molecular Medicine 17, no. 5 (2006): 791-794. https://doi.org/10.3892/ijmm.17.5.791
Copy and paste a formatted citation
x
Spandidos Publications style
Kölsch H, Lütjohann D, Jessen F, Von Bergmann K, Schmitz S, Urbach H, Maier W and Heun R: Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease. Int J Mol Med 17: 791-794, 2006.
APA
Kölsch, H., Lütjohann, D., Jessen, F., Von Bergmann, K., Schmitz, S., Urbach, H. ... Heun, R. (2006). Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease. International Journal of Molecular Medicine, 17, 791-794. https://doi.org/10.3892/ijmm.17.5.791
MLA
Kölsch, H., Lütjohann, D., Jessen, F., Von Bergmann, K., Schmitz, S., Urbach, H., Maier, W., Heun, R."Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease". International Journal of Molecular Medicine 17.5 (2006): 791-794.
Chicago
Kölsch, H., Lütjohann, D., Jessen, F., Von Bergmann, K., Schmitz, S., Urbach, H., Maier, W., Heun, R."Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease". International Journal of Molecular Medicine 17, no. 5 (2006): 791-794. https://doi.org/10.3892/ijmm.17.5.791
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