Deletion of the kinase domain from death-associated protein kinase enhances spatial memory in mice

Yukawa,Kazunori; Tanaka,Tetsuji; Bai,Tao; Li,Li; Tsubota,Yuji; Owada-Makabe,Kyoko; Maeda,Masanobu; Hoshino,Katsuaki; Akira,Shizuo; Iso,Hiroyuki

doi:10.3892/ijmm.17.5.869

May 2006 Volume 17 Issue 5

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May 2006 Volume 17 Issue 5

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Article

Deletion of the kinase domain from death-associated protein kinase enhances spatial memory in mice

Authors:
- Kazunori Yukawa
- Tetsuji Tanaka
- Tao Bai
- Li Li
- Yuji Tsubota
- Kyoko Owada-Makabe
- Masanobu Maeda
- Katsuaki Hoshino
- Shizuo Akira
- Hiroyuki Iso
View Affiliations / Copyright

Affiliations: Department of Physiology, Wakayama Medical University, Wakayama 641-8509, Japan. E-mail: kazu59@wakayama-med.ac.jp
Pages: 869-873
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Published online on: May 1, 2006

https://doi.org/10.3892/ijmm.17.5.869
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Abstract

Death-associated protein kinase (DAPK) is a Ca2+/calmodulin-dependent serine/threonine kinase that is thought to mediate apoptosis. DAPK is highly expressed in hippocampal neurons which are essential elements for memory formation. To examine if DAPK is implicated in spatial learning and memory, both wild-type and DAPK-mutant mice were subjected to Morris water maze tests. DAPK-mutant mice were generated by deleting 74 amino acids from the catalytic kinase domain of DAPK, and were used to investigate roles of the DAPK kinase domain in regulating spatial memory. Both mutant and wild-type mice were able to learn the water maze tasks to locate a hidden escape platform. In the first probe test, mutant mice showed a more precise memory for platform position compared to wild-type mice. In the reversal training in which the platform was located opposite from the original position, DAPK-mutant mice exhibited superior spatial learning compared to wild-type mice. DAPK-mutant mice also showed a more precise memory than their wild-type littermates in the probe trial of reversal test. Thus, the present results revealed crucial implications of DAPK in regulating spatial memory in mice.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Deletion of the kinase domain from death-associated protein kinase enhances spatial memory in mice

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