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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June 2006 Volume 17 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2006 Volume 17 Issue 6

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Article

The differential expression of SPARC in esophageal squamous cell carcinoma

  • Authors:
    • Yiqun Che
    • Aiping Luo
    • Hai Wang
    • Jun Qi
    • Jian Guo
    • Zhihua Liu

  • View Affiliations / Copyright

    Affiliations: National Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China
  • Pages: 1027-1033
    |
    Published online on: June 1, 2006
       https://doi.org/10.3892/ijmm.17.6.1027
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Abstract

Secreted protein, acidic and rich in cysteine (SPARC) is a matricellular protein that modulates cell adhesion and growth. The aim of this study was to assess the prevalence of SPARC mRNA and protein expression in esophageal squamous cell carcinoma (ESCC) and to investigate the role of SPARC in proliferation and metastasis of ESCC. The differential expression of SPARC between esophageal squamous cell carcinoma and its corresponding normal esophageal mucosa was analyzed by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry, as well as Western blotting. The expression of SPARC in ESCC was significantly higher than that in the corresponding normal esophageal mucosa as shown by semi-quantitative RT-PCR, immunohistochemistry and Western blotting. Meanwhile, SPARC protein was also significantly up-regulated in ESCC compared with the corresponding normal esophageal mucosa. SPARC protein was located in the cytoplasm and nuclei of ESCC cells. The results of Western blotting showed that out of 18 paired samples, SPARC was up-regulated in 13 cases, no significant differences were found for the other 5 cases. These findings revealed that SPARC was up-regulated in ESCC and was closely associated with ESCC metastasis. This study provides new insights into nuclei location of SPARC.

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Copy and paste a formatted citation
Spandidos Publications style
Che Y, Luo A, Wang H, Qi J, Guo J and Liu Z: The differential expression of SPARC in esophageal squamous cell carcinoma. Int J Mol Med 17: 1027-1033, 2006.
APA
Che, Y., Luo, A., Wang, H., Qi, J., Guo, J., & Liu, Z. (2006). The differential expression of SPARC in esophageal squamous cell carcinoma. International Journal of Molecular Medicine, 17, 1027-1033. https://doi.org/10.3892/ijmm.17.6.1027
MLA
Che, Y., Luo, A., Wang, H., Qi, J., Guo, J., Liu, Z."The differential expression of SPARC in esophageal squamous cell carcinoma". International Journal of Molecular Medicine 17.6 (2006): 1027-1033.
Chicago
Che, Y., Luo, A., Wang, H., Qi, J., Guo, J., Liu, Z."The differential expression of SPARC in esophageal squamous cell carcinoma". International Journal of Molecular Medicine 17, no. 6 (2006): 1027-1033. https://doi.org/10.3892/ijmm.17.6.1027
Copy and paste a formatted citation
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Spandidos Publications style
Che Y, Luo A, Wang H, Qi J, Guo J and Liu Z: The differential expression of SPARC in esophageal squamous cell carcinoma. Int J Mol Med 17: 1027-1033, 2006.
APA
Che, Y., Luo, A., Wang, H., Qi, J., Guo, J., & Liu, Z. (2006). The differential expression of SPARC in esophageal squamous cell carcinoma. International Journal of Molecular Medicine, 17, 1027-1033. https://doi.org/10.3892/ijmm.17.6.1027
MLA
Che, Y., Luo, A., Wang, H., Qi, J., Guo, J., Liu, Z."The differential expression of SPARC in esophageal squamous cell carcinoma". International Journal of Molecular Medicine 17.6 (2006): 1027-1033.
Chicago
Che, Y., Luo, A., Wang, H., Qi, J., Guo, J., Liu, Z."The differential expression of SPARC in esophageal squamous cell carcinoma". International Journal of Molecular Medicine 17, no. 6 (2006): 1027-1033. https://doi.org/10.3892/ijmm.17.6.1027
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