Evaluating strategies to enhance the anti-tumor immune response to a carbohydrate mimetic peptide vaccine

  • Authors:
    • Behjatolah Monzavi-Karbassi
    • Anastas Pashov
    • Fariba Jousheghany
    • Cecile Artaud
    • Thomas Kieber-Emmons
  • View Affiliations

  • Published online on: June 1, 2006     https://doi.org/10.3892/ijmm.17.6.1045
  • Pages: 1045-1052
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Carbohydrate mimetic peptides of tumor associated carbohydrate antigens (TACA) are T-cell-dependent antigens and, therefore, immunization with these surrogates is predicted to overcome the low immunogenicity of carbohydrate antigens. Consistent with this hypothesis, we show that among the potential immune cells involved, peptide immunization led to an increase in T-cell populations. While peptide mimetics may also function as TLR binding ligands, we did not observe evidence of involvement of NK cells. Examining tumor challenged animals, we observed that peptide immunization and not tumor cells rendered IL-12 responsiveness to T-cells, as T-cells from peptide-immunized mice produced IFN-γ upon stimulation with IL-12. Cyclophosphamide administration enhanced the anti-tumor efficacy of the vaccine, which was achieved by enhancing T-cell responses with no effect on NK cell population. Prophylactic immunization of mice with a DNA construct encoding carbohydrate mimetic peptides indicated a specific role for the mimotope vaccine in anti-tumor immune responses. These data suggest a role for both CD4+ and CD8+ T-cells induced by mimotopes of TACA in protective immunity against tumor cells.

Related Articles

Journal Cover

June 2006
Volume 17 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Monzavi-Karbassi B, Pashov A, Jousheghany F, Artaud C and Kieber-Emmons T: Evaluating strategies to enhance the anti-tumor immune response to a carbohydrate mimetic peptide vaccine. Int J Mol Med 17: 1045-1052, 2006
APA
Monzavi-Karbassi, B., Pashov, A., Jousheghany, F., Artaud, C., & Kieber-Emmons, T. (2006). Evaluating strategies to enhance the anti-tumor immune response to a carbohydrate mimetic peptide vaccine. International Journal of Molecular Medicine, 17, 1045-1052. https://doi.org/10.3892/ijmm.17.6.1045
MLA
Monzavi-Karbassi, B., Pashov, A., Jousheghany, F., Artaud, C., Kieber-Emmons, T."Evaluating strategies to enhance the anti-tumor immune response to a carbohydrate mimetic peptide vaccine". International Journal of Molecular Medicine 17.6 (2006): 1045-1052.
Chicago
Monzavi-Karbassi, B., Pashov, A., Jousheghany, F., Artaud, C., Kieber-Emmons, T."Evaluating strategies to enhance the anti-tumor immune response to a carbohydrate mimetic peptide vaccine". International Journal of Molecular Medicine 17, no. 6 (2006): 1045-1052. https://doi.org/10.3892/ijmm.17.6.1045