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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June 2006 Volume 17 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation

  • Authors:
    • Jun Kondo
    • Fuyuki Sato
    • Katsumi Fujimoto
    • Tomomi Kusumi
    • Tadanobu Imanaka
    • Takeshi Kawamoto
    • Bhawal Uk
    • Mitsuhide Noshiro
    • Yukio Kato
    • Tatsusuke Sato
    • Hiroshi Kijima

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Hirosaki University School of Medicine, Hirosaki 036-8562, Japan
  • Pages: 1053-1056
    |
    Published online on: June 1, 2006
       https://doi.org/10.3892/ijmm.17.6.1053
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Abstract

The basic helix-loop-helix (bHLH) transcription factors, DEC2 and DEC1, play critical roles in the circadian rhythm of the suprachiasmatic nucleus (SCN). It is known that mammalian circadian rhythms are regulated by molecular clockwork systems based on a negative-feedback loop, and CLOCK/BMAL1 and CLOCK/BMAL2 enhance DEC2 transcription via CACGTG E-boxes. To understand the role of arginine 57 (57Arg) within the basic region of DEC2, we examined the effect of substituting this residue into DEC2 on CLOCK/BMAL2-mediated transactivation. A luciferase assay showed that substituting 57Arg for Ala or Lys in DEC2 diminished the suppressive activity of wild-type DEC2 on CLOCK/BMAL2-mediated transactivation, while substituting 48Pro for Ala in DEC2 did not alter it, and the same was true for wild-type DEC2. We also showed that proteins which were wild-type and substitution mutants of DEC2 were expressed at nearly equivalent levels by Western blotting. These findings demonstrate that 57Arg in the basic region of DEC2 is essential for its activity in suppressing CLOCK/BMAL2-mediated transactivation.

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Copy and paste a formatted citation
Spandidos Publications style
Kondo J, Sato F, Fujimoto K, Kusumi T, Imanaka T, Kawamoto T, Uk B, Noshiro M, Kato Y, Sato T, Sato T, et al: 57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation. Int J Mol Med 17: 1053-1056, 2006.
APA
Kondo, J., Sato, F., Fujimoto, K., Kusumi, T., Imanaka, T., Kawamoto, T. ... Kijima, H. (2006). 57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation. International Journal of Molecular Medicine, 17, 1053-1056. https://doi.org/10.3892/ijmm.17.6.1053
MLA
Kondo, J., Sato, F., Fujimoto, K., Kusumi, T., Imanaka, T., Kawamoto, T., Uk, B., Noshiro, M., Kato, Y., Sato, T., Kijima, H."57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation". International Journal of Molecular Medicine 17.6 (2006): 1053-1056.
Chicago
Kondo, J., Sato, F., Fujimoto, K., Kusumi, T., Imanaka, T., Kawamoto, T., Uk, B., Noshiro, M., Kato, Y., Sato, T., Kijima, H."57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation". International Journal of Molecular Medicine 17, no. 6 (2006): 1053-1056. https://doi.org/10.3892/ijmm.17.6.1053
Copy and paste a formatted citation
x
Spandidos Publications style
Kondo J, Sato F, Fujimoto K, Kusumi T, Imanaka T, Kawamoto T, Uk B, Noshiro M, Kato Y, Sato T, Sato T, et al: 57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation. Int J Mol Med 17: 1053-1056, 2006.
APA
Kondo, J., Sato, F., Fujimoto, K., Kusumi, T., Imanaka, T., Kawamoto, T. ... Kijima, H. (2006). 57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation. International Journal of Molecular Medicine, 17, 1053-1056. https://doi.org/10.3892/ijmm.17.6.1053
MLA
Kondo, J., Sato, F., Fujimoto, K., Kusumi, T., Imanaka, T., Kawamoto, T., Uk, B., Noshiro, M., Kato, Y., Sato, T., Kijima, H."57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation". International Journal of Molecular Medicine 17.6 (2006): 1053-1056.
Chicago
Kondo, J., Sato, F., Fujimoto, K., Kusumi, T., Imanaka, T., Kawamoto, T., Uk, B., Noshiro, M., Kato, Y., Sato, T., Kijima, H."57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation". International Journal of Molecular Medicine 17, no. 6 (2006): 1053-1056. https://doi.org/10.3892/ijmm.17.6.1053
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