Urotensin-II and UII-receptor expression and function in the rat adrenal cortex

  • Authors:
    • Giovanna Albertin
    • Valentina Casale
    • Agnieszka Ziolkowska
    • Raffaella Spinazzi
    • Ludwik K. Malendowicz
    • Gian Paolo Rossi
    • Gastone G. Nussdorfer
  • View Affiliations

  • Published online on: June 1, 2006     https://doi.org/10.3892/ijmm.17.6.1111
  • Pages: 1111-1115
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Urotensin-II (UII) is a potent hypertensive peptide, which has been recognized as an endogenous ligand of the G protein-coupled receptor (GPR)-14, now named UT-R. Real-time PCR demonstrated the expression of UII and UT-R mRNAs in both dispersed and in vitro cultured rat adrenocortical cells. UII concentration-dependently decreased basal, but not ACTH-stimulated, corticosterone secretion from cultured adrenocortical cells, and the effect was abolished by the UT-R antagonist Palosuran. UII did not affect the proliferation rate of cultured cells. Taken together, these findings suggest that UII may be included in the group of peptides (adrenomedullin, atrial natriuretic peptide, neurotensin and beacon), that, acting in an autocrine-paracrine manner, are involved in the inhibitory tuning of adrenocortical secretion.

Related Articles

Journal Cover

June 2006
Volume 17 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Albertin G, Casale V, Ziolkowska A, Spinazzi R, Malendowicz LK, Rossi GP and Nussdorfer GG: Urotensin-II and UII-receptor expression and function in the rat adrenal cortex. Int J Mol Med 17: 1111-1115, 2006
APA
Albertin, G., Casale, V., Ziolkowska, A., Spinazzi, R., Malendowicz, L.K., Rossi, G.P., & Nussdorfer, G.G. (2006). Urotensin-II and UII-receptor expression and function in the rat adrenal cortex. International Journal of Molecular Medicine, 17, 1111-1115. https://doi.org/10.3892/ijmm.17.6.1111
MLA
Albertin, G., Casale, V., Ziolkowska, A., Spinazzi, R., Malendowicz, L. K., Rossi, G. P., Nussdorfer, G. G."Urotensin-II and UII-receptor expression and function in the rat adrenal cortex". International Journal of Molecular Medicine 17.6 (2006): 1111-1115.
Chicago
Albertin, G., Casale, V., Ziolkowska, A., Spinazzi, R., Malendowicz, L. K., Rossi, G. P., Nussdorfer, G. G."Urotensin-II and UII-receptor expression and function in the rat adrenal cortex". International Journal of Molecular Medicine 17, no. 6 (2006): 1111-1115. https://doi.org/10.3892/ijmm.17.6.1111