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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2006 Volume 18 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells

  • Authors:
    • Hayato Maeda
    • Masashi Hosokawa
    • Tokutake Sashima
    • Nobuyuki Takahashi
    • Teruo Kawada
    • Kazuo Miyashita

  • View Affiliations / Copyright

    Affiliations: Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan
  • Pages: 147-152
    |
    Published online on: July 1, 2006
       https://doi.org/10.3892/ijmm.18.1.147
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Abstract

Fucoxanthin is a major carotenoid found in edible seaweed such as Undaria pinnatifida and Hijikia fusiformis. We investigated the suppressive effects of fucoxanthin and its metabolite, fucoxanthinol, on the differentiation of 3T3-L1 preadipocytes to adipocytes. Fucoxanthin inhibited intercellular lipid accumulation during adipocyte differentiation of 3T3-L1 cells. Furthermore, fucoxanthin was converted to fucoxanthinol in 3T3-L1 cells. Fucoxanthinol also exhibited suppressive effects on lipid accumulation and decreased glycerol-3-phosphate dehydrogenase activity, an indicator of adipocyte differentiation. The suppressive effect of fucoxanthinol was stronger than that of fucoxanthin. In addition, in 3T3-L1 cells treated with fucoxanthin and fucoxanthinol, peroxisome proliferator-activated receptor γ (PPARγ), which regulates adipogenic gene expression, was down-regulated in a dose-dependent manner. These results suggest that fucoxanthin and fucoxanthinol inhibit the adipocyte differentiation of 3T3-L1 cells through down-regulation of PPARγ. Fucoxanthinol had stronger suppressive effects than fucoxanthin on adipocyte differentiation in 3T3-L1 cells.

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Copy and paste a formatted citation
Spandidos Publications style
Maeda H, Hosokawa M, Sashima T, Takahashi N, Kawada T and Miyashita K: Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells. Int J Mol Med 18: 147-152, 2006.
APA
Maeda, H., Hosokawa, M., Sashima, T., Takahashi, N., Kawada, T., & Miyashita, K. (2006). Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells. International Journal of Molecular Medicine, 18, 147-152. https://doi.org/10.3892/ijmm.18.1.147
MLA
Maeda, H., Hosokawa, M., Sashima, T., Takahashi, N., Kawada, T., Miyashita, K."Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells". International Journal of Molecular Medicine 18.1 (2006): 147-152.
Chicago
Maeda, H., Hosokawa, M., Sashima, T., Takahashi, N., Kawada, T., Miyashita, K."Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells". International Journal of Molecular Medicine 18, no. 1 (2006): 147-152. https://doi.org/10.3892/ijmm.18.1.147
Copy and paste a formatted citation
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Spandidos Publications style
Maeda H, Hosokawa M, Sashima T, Takahashi N, Kawada T and Miyashita K: Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells. Int J Mol Med 18: 147-152, 2006.
APA
Maeda, H., Hosokawa, M., Sashima, T., Takahashi, N., Kawada, T., & Miyashita, K. (2006). Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells. International Journal of Molecular Medicine, 18, 147-152. https://doi.org/10.3892/ijmm.18.1.147
MLA
Maeda, H., Hosokawa, M., Sashima, T., Takahashi, N., Kawada, T., Miyashita, K."Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells". International Journal of Molecular Medicine 18.1 (2006): 147-152.
Chicago
Maeda, H., Hosokawa, M., Sashima, T., Takahashi, N., Kawada, T., Miyashita, K."Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells". International Journal of Molecular Medicine 18, no. 1 (2006): 147-152. https://doi.org/10.3892/ijmm.18.1.147
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