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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2006 Volume 18 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2006 Volume 18 Issue 4

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Article

Estradiol and resveratrol stimulating effect on osteocalcin, but not osteonectin and collagen-1α gene expression in primary culture of rat calvarial osteoblast-like cells

  • Authors:
    • Marcin Rucinski
    • Agnieszka Ziolkowska
    • Anna Hochol
    • Andrzej Pucher
    • Carlo Macchi
    • Anna S. Belloni
    • Gastone G. Nussdorfer
    • Ludwik K. Malendowicz
  • View Affiliations / Copyright

    Affiliations: Department of Histology and Embryology, Poznan University of Medical Sciences, PL-60781 Poznan, Poland
  • Pages: 565-570
    |
    Published online on: October 1, 2006
       https://doi.org/10.3892/ijmm.18.4.565
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Abstract

Evidence is available that some endocrine disruptors, acting as selective estrogen receptor modulators (SERMs), interfere with osteoblast differentiation and function. Therefore, we investigated whether 17β-estradiol, bisphenol-A (BSP), silymarin, genistein, resveratrol, procymidone, linurone and benzophenone-3 (BP3) modulate differentiation of rat calvarial osteoblast-like (ROB) cells in primary in vitro culture. Disruptors were added at day 18 of culture and cells were harvested 48 h later. Real time-PCR revealed that estradiol and resveratrol enhanced osteocalcin mRNA expression in ROB cells, while other disruptors were ineffective. The expression of osteonectin and collagen-1α was not affected by any disruptor. Estradiol, resveratrol, genistein and BSP stimulated the proliferative activity of ROB cells. In contrast, procymidone and linurone inhibited the proliferative activity, and silymarin and BP3 were ineffective. The conclusion is drawn that i) only resveratrol is able, like estradiol, to stimulate the specialized functions of ROB cells, and ii) the proliferative activity of ROB cells is more sensitive to endocrine disruptors, some of which could probably act via a mechanism independent of their SERM activity.

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Copy and paste a formatted citation
Spandidos Publications style
Rucinski M, Ziolkowska A, Hochol A, Pucher A, Macchi C, Belloni AS, Nussdorfer GG and Malendowicz LK: Estradiol and resveratrol stimulating effect on osteocalcin, but not osteonectin and collagen-1α gene expression in primary culture of rat calvarial osteoblast-like cells. Int J Mol Med 18: 565-570, 2006.
APA
Rucinski, M., Ziolkowska, A., Hochol, A., Pucher, A., Macchi, C., Belloni, A.S. ... Malendowicz, L.K. (2006). Estradiol and resveratrol stimulating effect on osteocalcin, but not osteonectin and collagen-1α gene expression in primary culture of rat calvarial osteoblast-like cells. International Journal of Molecular Medicine, 18, 565-570. https://doi.org/10.3892/ijmm.18.4.565
MLA
Rucinski, M., Ziolkowska, A., Hochol, A., Pucher, A., Macchi, C., Belloni, A. S., Nussdorfer, G. G., Malendowicz, L. K."Estradiol and resveratrol stimulating effect on osteocalcin, but not osteonectin and collagen-1α gene expression in primary culture of rat calvarial osteoblast-like cells". International Journal of Molecular Medicine 18.4 (2006): 565-570.
Chicago
Rucinski, M., Ziolkowska, A., Hochol, A., Pucher, A., Macchi, C., Belloni, A. S., Nussdorfer, G. G., Malendowicz, L. K."Estradiol and resveratrol stimulating effect on osteocalcin, but not osteonectin and collagen-1α gene expression in primary culture of rat calvarial osteoblast-like cells". International Journal of Molecular Medicine 18, no. 4 (2006): 565-570. https://doi.org/10.3892/ijmm.18.4.565
Copy and paste a formatted citation
x
Spandidos Publications style
Rucinski M, Ziolkowska A, Hochol A, Pucher A, Macchi C, Belloni AS, Nussdorfer GG and Malendowicz LK: Estradiol and resveratrol stimulating effect on osteocalcin, but not osteonectin and collagen-1α gene expression in primary culture of rat calvarial osteoblast-like cells. Int J Mol Med 18: 565-570, 2006.
APA
Rucinski, M., Ziolkowska, A., Hochol, A., Pucher, A., Macchi, C., Belloni, A.S. ... Malendowicz, L.K. (2006). Estradiol and resveratrol stimulating effect on osteocalcin, but not osteonectin and collagen-1α gene expression in primary culture of rat calvarial osteoblast-like cells. International Journal of Molecular Medicine, 18, 565-570. https://doi.org/10.3892/ijmm.18.4.565
MLA
Rucinski, M., Ziolkowska, A., Hochol, A., Pucher, A., Macchi, C., Belloni, A. S., Nussdorfer, G. G., Malendowicz, L. K."Estradiol and resveratrol stimulating effect on osteocalcin, but not osteonectin and collagen-1α gene expression in primary culture of rat calvarial osteoblast-like cells". International Journal of Molecular Medicine 18.4 (2006): 565-570.
Chicago
Rucinski, M., Ziolkowska, A., Hochol, A., Pucher, A., Macchi, C., Belloni, A. S., Nussdorfer, G. G., Malendowicz, L. K."Estradiol and resveratrol stimulating effect on osteocalcin, but not osteonectin and collagen-1α gene expression in primary culture of rat calvarial osteoblast-like cells". International Journal of Molecular Medicine 18, no. 4 (2006): 565-570. https://doi.org/10.3892/ijmm.18.4.565
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