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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2006 Volume 18 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2006 Volume 18 Issue 4

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Article

Role of vascular endothelial growth factor in protein loss of Ménétrier's disease

  • Authors:
    • Teiko Takeda
    • Keiichi Mitsuyama
    • Osamu Tsuruta
    • Shinichi Kuboyama
    • Shigehiko Kitazaki
    • Michio Sata

  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan
  • Pages: 571-576
    |
    Published online on: October 1, 2006
       https://doi.org/10.3892/ijmm.18.4.571
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Abstract

Vascular endothelial growth factor (VEGF) promotes protein leakage from blood vessels and endothelial cell growth. The expression of transforming growth factor (TGF)-α and its receptor is increased in the gastric mucosa of patients with Ménétrier's disease. Since TGF-α stimulates the expression of VEGF mRNA in cultured keratinocytes, we hypothesized that VEGF may play an important role in the protein leakage of Ménétrier's disease. Immunohistochemistry was performed using specific antibodies against VEGF and CD31 in gastric tissue specimens from 7 patients with Ménétrier's disease and 10 controls. The effect of recombinant TGF-α on VEGF production by cultured lamina propria mononuclear cells (LPMCs) was assessed. VEGF expression was detected for LPMCs and occasional epithelial cells of the gastric mucosa of Ménétrier's patients. VEGF-positive LPMCs were increased in tissues from patients with Ménétrier's disease (P<0.001). Of the LPMCs, T-lymphocytes and macrophages were the major sources of VEGF. CD31-positive blood vessels were increased in Ménétrier's tissue. (P<0.05). Recombinant TGF-α induced the production of VEGF in cultured LPMCs (P<0.05). In conclusion, the increased expression of VEGF, as a result of overproduction of TGF-α, may play a key role in the pathophysiology of Ménétrier's disease.

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Copy and paste a formatted citation
Spandidos Publications style
Takeda T, Mitsuyama K, Tsuruta O, Kuboyama S, Kitazaki S and Sata M: Role of vascular endothelial growth factor in protein loss of Ménétrier's disease. Int J Mol Med 18: 571-576, 2006.
APA
Takeda, T., Mitsuyama, K., Tsuruta, O., Kuboyama, S., Kitazaki, S., & Sata, M. (2006). Role of vascular endothelial growth factor in protein loss of Ménétrier's disease. International Journal of Molecular Medicine, 18, 571-576. https://doi.org/10.3892/ijmm.18.4.571
MLA
Takeda, T., Mitsuyama, K., Tsuruta, O., Kuboyama, S., Kitazaki, S., Sata, M."Role of vascular endothelial growth factor in protein loss of Ménétrier's disease". International Journal of Molecular Medicine 18.4 (2006): 571-576.
Chicago
Takeda, T., Mitsuyama, K., Tsuruta, O., Kuboyama, S., Kitazaki, S., Sata, M."Role of vascular endothelial growth factor in protein loss of Ménétrier's disease". International Journal of Molecular Medicine 18, no. 4 (2006): 571-576. https://doi.org/10.3892/ijmm.18.4.571
Copy and paste a formatted citation
x
Spandidos Publications style
Takeda T, Mitsuyama K, Tsuruta O, Kuboyama S, Kitazaki S and Sata M: Role of vascular endothelial growth factor in protein loss of Ménétrier's disease. Int J Mol Med 18: 571-576, 2006.
APA
Takeda, T., Mitsuyama, K., Tsuruta, O., Kuboyama, S., Kitazaki, S., & Sata, M. (2006). Role of vascular endothelial growth factor in protein loss of Ménétrier's disease. International Journal of Molecular Medicine, 18, 571-576. https://doi.org/10.3892/ijmm.18.4.571
MLA
Takeda, T., Mitsuyama, K., Tsuruta, O., Kuboyama, S., Kitazaki, S., Sata, M."Role of vascular endothelial growth factor in protein loss of Ménétrier's disease". International Journal of Molecular Medicine 18.4 (2006): 571-576.
Chicago
Takeda, T., Mitsuyama, K., Tsuruta, O., Kuboyama, S., Kitazaki, S., Sata, M."Role of vascular endothelial growth factor in protein loss of Ménétrier's disease". International Journal of Molecular Medicine 18, no. 4 (2006): 571-576. https://doi.org/10.3892/ijmm.18.4.571
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