Genetic factors for obesity

  • Authors:
    • Yoshiji Yamada
    • Kimihiko Kato
    • Takashi Kameyama
    • Kiyoshi Yokoi
    • Hitoshi Matsuo
    • Tomonori Segawa
    • Sachiro Watanabe
    • Sahoko Ichihara
    • Hidemi Yoshida
    • Kei Satoh
    • Yoshinori Nozawa
  • View Affiliations

  • Published online on: November 1, 2006     https://doi.org/10.3892/ijmm.18.5.843
  • Pages: 843-851
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Abstract

The purpose of the present study was to identify gene polymorphisms for the reliable assessment of genetic factors for obesity. The study population comprised 3906 unrelated Japanese individuals (2286 men, 1620 women), including 1196 subjects (677 men, 519 women) with obesity (body mass index of ≥25 kg/m2) and 2710 controls (1609 men, 1101 women). The genotypes for 147 polymorphisms of 124 candidate genes were determined with a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. Multivariable logistic regression analysis with adjustment for age, sex, and the prevalence of smoking revealed that the -30G↷A polymorphism of GCK, the -240A↷T polymorphism of ACE, and the -482C↷T polymorphism of APOC3 were significantly (P<0.01) associated with the prevalence of obesity, and the -1989T↷G polymorphism of ESR1 was almost significantly associated. A stepwise forward selection procedure demonstrated that ACE, GCK, and ESR1 genotypes significantly (P<0.01) and independently affected the prevalence of obesity. Combined genotype analysis for these three polymorphisms yielded a lowest odds ratio of 0.45 for the combined genotypes of AT or TT for ACE, GG for GCK, and GG for ESR1 in comparison with the combined genotypes of AA for ACE, GG for GCK, and TT or TG for ESR1. Genotypes for ACE, GCK, and ESR1 may prove reliable for the assessment of genetic factors for obesity. Determination of the combined genotypes for these genes may contribute to the personalized prevention of this condition.

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November 2006
Volume 18 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yamada Y, Kato K, Kameyama T, Yokoi K, Matsuo H, Segawa T, Watanabe S, Ichihara S, Yoshida H, Satoh K, Satoh K, et al: Genetic factors for obesity. Int J Mol Med 18: 843-851, 2006
APA
Yamada, Y., Kato, K., Kameyama, T., Yokoi, K., Matsuo, H., Segawa, T. ... Nozawa, Y. (2006). Genetic factors for obesity. International Journal of Molecular Medicine, 18, 843-851. https://doi.org/10.3892/ijmm.18.5.843
MLA
Yamada, Y., Kato, K., Kameyama, T., Yokoi, K., Matsuo, H., Segawa, T., Watanabe, S., Ichihara, S., Yoshida, H., Satoh, K., Nozawa, Y."Genetic factors for obesity". International Journal of Molecular Medicine 18.5 (2006): 843-851.
Chicago
Yamada, Y., Kato, K., Kameyama, T., Yokoi, K., Matsuo, H., Segawa, T., Watanabe, S., Ichihara, S., Yoshida, H., Satoh, K., Nozawa, Y."Genetic factors for obesity". International Journal of Molecular Medicine 18, no. 5 (2006): 843-851. https://doi.org/10.3892/ijmm.18.5.843