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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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December 2006 Volume 18 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2006 Volume 18 Issue 6

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Article

Epigallocatechin gallate and genistein attenuate glial fibrillary acidic protein elevation induced by fibrogenic cytokines in hepatic stellate cells

  • Authors:
    • Chunyan Zhang
    • Lang Zhuo

  • View Affiliations / Copyright

    Affiliations: Institute of Bioengineering and Nanotechnology, 138669 Singapore
  • Pages: 1141-1151
    |
    Published online on: December 1, 2006
       https://doi.org/10.3892/ijmm.18.6.1141
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Abstract

Hepatic stellate cells (HSCs) play a pivotal role in hepatic fibrogenesis, and are considered a cellular target for therapeutic intervention. We recently established that a 2.2-kb hGFAP (human glial fibrillary acidic protein) promoter could be used to specifically target cultured HSCs. In the current study, we aimed to investigate whether the same transgene (2.2-kb hGFAP-lacZ) can be used as a biomarker for studying the inhibition of HSC activation. HSC-T6 cells stably transfected with the transgene were treated with two natural anti-fibrotic compounds, epigallocatechin gallate (EGCG) and genistein separately. Results showed that both transgenic β-galactosidase activity and endogenous GFAP expression (mRNA and protein) were attenuated by EGCG or genistein treatment in a dose- and time-dependent manner. Our data further demonstrated that the suppression of fibrogenic end-points was primarily mediated through the inhibition of AP-1 signaling (and to a lesser degree through the NFκB pathway) onto the GFAP promoter. In conclusion, the current findings provide a proof-of-concept for using GFAP for studying HSC activation and inhibition. It could be envisioned that a HSC-based high-throughput system can be constructed using the GFAP promoter in conjunction with a real-time reporter for the screening of anti-fibrotic and anti-inflammatory agents.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang C and Zhuo L: Epigallocatechin gallate and genistein attenuate glial fibrillary acidic protein elevation induced by fibrogenic cytokines in hepatic stellate cells. Int J Mol Med 18: 1141-1151, 2006.
APA
Zhang, C., & Zhuo, L. (2006). Epigallocatechin gallate and genistein attenuate glial fibrillary acidic protein elevation induced by fibrogenic cytokines in hepatic stellate cells. International Journal of Molecular Medicine, 18, 1141-1151. https://doi.org/10.3892/ijmm.18.6.1141
MLA
Zhang, C., Zhuo, L."Epigallocatechin gallate and genistein attenuate glial fibrillary acidic protein elevation induced by fibrogenic cytokines in hepatic stellate cells". International Journal of Molecular Medicine 18.6 (2006): 1141-1151.
Chicago
Zhang, C., Zhuo, L."Epigallocatechin gallate and genistein attenuate glial fibrillary acidic protein elevation induced by fibrogenic cytokines in hepatic stellate cells". International Journal of Molecular Medicine 18, no. 6 (2006): 1141-1151. https://doi.org/10.3892/ijmm.18.6.1141
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang C and Zhuo L: Epigallocatechin gallate and genistein attenuate glial fibrillary acidic protein elevation induced by fibrogenic cytokines in hepatic stellate cells. Int J Mol Med 18: 1141-1151, 2006.
APA
Zhang, C., & Zhuo, L. (2006). Epigallocatechin gallate and genistein attenuate glial fibrillary acidic protein elevation induced by fibrogenic cytokines in hepatic stellate cells. International Journal of Molecular Medicine, 18, 1141-1151. https://doi.org/10.3892/ijmm.18.6.1141
MLA
Zhang, C., Zhuo, L."Epigallocatechin gallate and genistein attenuate glial fibrillary acidic protein elevation induced by fibrogenic cytokines in hepatic stellate cells". International Journal of Molecular Medicine 18.6 (2006): 1141-1151.
Chicago
Zhang, C., Zhuo, L."Epigallocatechin gallate and genistein attenuate glial fibrillary acidic protein elevation induced by fibrogenic cytokines in hepatic stellate cells". International Journal of Molecular Medicine 18, no. 6 (2006): 1141-1151. https://doi.org/10.3892/ijmm.18.6.1141
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