Interleukin-18 regulates T helper 1 or 2 immune responses of human cord blood CD4+ Vα24+Vβ11+ natural killer T cells

  • Authors:
    • Yuka Fujibayashi
    • Yoshihiro Fujimori
    • Ikuyo Kasumoto
    • Shunro Kai
    • Hiroshi Hara
    • Haruki Okamura
    • Hiroko Tsutsui
    • Hiroyasu Ogawa
    • Kenji Nakanishi
  • View Affiliations

  • Published online on: August 1, 2007     https://doi.org/10.3892/ijmm.20.2.241
  • Pages: 241-245
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Abstract

Natural killer T (NKT) cells, exhibiting both T-cell and NK-cell markers, are known to regulate immune responses by secreting T-helper (Th) 1 and Th2 cytokines. We analyzed NKT cells in cord blood (CB) for phenotypical and functional characteristics and regulatory mechanisms that control Th1 and Th2 determination. Human CB Vα24+Vβ11+ NKT cells were predominantly the CD4+ single positive (SP) phenotype (approximately 96%), in contrast to adult peripheral blood Vα24+Vβ11+ NKT cells which are composed of a dominant population of the CD4−CD8−double negative (DN) phenotype and a minor population of the CD4+ SP phenotype. The CB CD4+ Vα24+ NKT cells, following stimulation with the primary culture, gained the capacity to secrete interferon (IFN)-γ, a Th1 cytokine, and interleukin (IL)-13, a Th2 cytokine. The combination of IL-18 and IL-12 induced IFN-γ production in CB CD4+ Vα24+ NKT cells, while IL-18 in combination with IL-2 induced IL-13 production in these cells. Thus, IL-18 regulates the determination of the Th1 or Th2 immune response by human CD4+ Vα24+ NKT cells through different cytokine combinations.

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August 2007
Volume 20 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Fujibayashi Y, Fujimori Y, Kasumoto I, Kai S, Hara H, Okamura H, Tsutsui H, Ogawa H and Nakanishi K: Interleukin-18 regulates T helper 1 or 2 immune responses of human cord blood CD4+ Vα24+Vβ11+ natural killer T cells. Int J Mol Med 20: 241-245, 2007
APA
Fujibayashi, Y., Fujimori, Y., Kasumoto, I., Kai, S., Hara, H., Okamura, H. ... Nakanishi, K. (2007). Interleukin-18 regulates T helper 1 or 2 immune responses of human cord blood CD4+ Vα24+Vβ11+ natural killer T cells. International Journal of Molecular Medicine, 20, 241-245. https://doi.org/10.3892/ijmm.20.2.241
MLA
Fujibayashi, Y., Fujimori, Y., Kasumoto, I., Kai, S., Hara, H., Okamura, H., Tsutsui, H., Ogawa, H., Nakanishi, K."Interleukin-18 regulates T helper 1 or 2 immune responses of human cord blood CD4+ Vα24+Vβ11+ natural killer T cells". International Journal of Molecular Medicine 20.2 (2007): 241-245.
Chicago
Fujibayashi, Y., Fujimori, Y., Kasumoto, I., Kai, S., Hara, H., Okamura, H., Tsutsui, H., Ogawa, H., Nakanishi, K."Interleukin-18 regulates T helper 1 or 2 immune responses of human cord blood CD4+ Vα24+Vβ11+ natural killer T cells". International Journal of Molecular Medicine 20, no. 2 (2007): 241-245. https://doi.org/10.3892/ijmm.20.2.241