Estrogen induces cardioprotection in male C57BL/6J mice after acute myocardial infarction via decreased activity of matrix metalloproteinase-9 and increased Akt-Bcl-2 anti-apoptotic signaling

  • Authors:
    • Jiumei Cao
    • Tianqi Zhu
    • Lin Lu
    • Liang Geng
    • Lingjie Wang
    • Qi Zhang
    • Ke Yang
    • Haibo Wang
    • Weifeng Shen
  • View Affiliations

  • Published online on: April 20, 2011     https://doi.org/10.3892/ijmm.2011.681
  • Pages: 231-237
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Abstract

In general, young men have a greater risk than age-matched women for many types of cardiovascular diseases, including ischemic heart diseases, such as acute or chronic myocardial infarction (MI)-induced heart failure. The effects of estrogen-replacement therapy in men have not been extensively studied. We evaluated the cardioprotective effects of supplemental estrogen against left anterior descending coronary ligation-induced MI in male C57BL/6J mice. A significantly lower prevalence of cardiac rupture was observed in estrogen-treated mice regardless of castration status. A reduced prevalence of cardiac rupture was associated with decreased activities of matrix metalloproteinase 9 (MMP-9) and increased expression of the anti-apoptotic gene Bcl-2. In vitro studies using H9C2 cells under simulated ischemia re-oxygenation treatment further support the role of estrogen receptor β in estrogen-mediated cardioprotection through the Akt-Bcl-2 signaling pathway.

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August 2011
Volume 28 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Cao J, Zhu T, Lu L, Geng L, Wang L, Zhang Q, Yang K, Wang H and Shen W: Estrogen induces cardioprotection in male C57BL/6J mice after acute myocardial infarction via decreased activity of matrix metalloproteinase-9 and increased Akt-Bcl-2 anti-apoptotic signaling. Int J Mol Med 28: 231-237, 2011
APA
Cao, J., Zhu, T., Lu, L., Geng, L., Wang, L., Zhang, Q. ... Shen, W. (2011). Estrogen induces cardioprotection in male C57BL/6J mice after acute myocardial infarction via decreased activity of matrix metalloproteinase-9 and increased Akt-Bcl-2 anti-apoptotic signaling. International Journal of Molecular Medicine, 28, 231-237. https://doi.org/10.3892/ijmm.2011.681
MLA
Cao, J., Zhu, T., Lu, L., Geng, L., Wang, L., Zhang, Q., Yang, K., Wang, H., Shen, W."Estrogen induces cardioprotection in male C57BL/6J mice after acute myocardial infarction via decreased activity of matrix metalloproteinase-9 and increased Akt-Bcl-2 anti-apoptotic signaling". International Journal of Molecular Medicine 28.2 (2011): 231-237.
Chicago
Cao, J., Zhu, T., Lu, L., Geng, L., Wang, L., Zhang, Q., Yang, K., Wang, H., Shen, W."Estrogen induces cardioprotection in male C57BL/6J mice after acute myocardial infarction via decreased activity of matrix metalloproteinase-9 and increased Akt-Bcl-2 anti-apoptotic signaling". International Journal of Molecular Medicine 28, no. 2 (2011): 231-237. https://doi.org/10.3892/ijmm.2011.681