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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2011 Volume 28 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2011 Volume 28 Issue 2

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Article

Estrogen induces cardioprotection in male C57BL/6J mice after acute myocardial infarction via decreased activity of matrix metalloproteinase-9 and increased Akt-Bcl-2 anti-apoptotic signaling

  • Authors:
    • Jiumei Cao
    • Tianqi Zhu
    • Lin Lu
    • Liang Geng
    • Lingjie Wang
    • Qi Zhang
    • Ke Yang
    • Haibo Wang
    • Weifeng Shen

  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China, Department of Cardiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Rui Jin Road II, Shanghai 200025, P.R. China
  • Pages: 231-237
    |
    Published online on: April 20, 2011
       https://doi.org/10.3892/ijmm.2011.681
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Abstract

In general, young men have a greater risk than age-matched women for many types of cardiovascular diseases, including ischemic heart diseases, such as acute or chronic myocardial infarction (MI)-induced heart failure. The effects of estrogen-replacement therapy in men have not been extensively studied. We evaluated the cardioprotective effects of supplemental estrogen against left anterior descending coronary ligation-induced MI in male C57BL/6J mice. A significantly lower prevalence of cardiac rupture was observed in estrogen-treated mice regardless of castration status. A reduced prevalence of cardiac rupture was associated with decreased activities of matrix metalloproteinase 9 (MMP-9) and increased expression of the anti-apoptotic gene Bcl-2. In vitro studies using H9C2 cells under simulated ischemia re-oxygenation treatment further support the role of estrogen receptor β in estrogen-mediated cardioprotection through the Akt-Bcl-2 signaling pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Cao J, Zhu T, Lu L, Geng L, Wang L, Zhang Q, Yang K, Wang H and Shen W: Estrogen induces cardioprotection in male C57BL/6J mice after acute myocardial infarction via decreased activity of matrix metalloproteinase-9 and increased Akt-Bcl-2 anti-apoptotic signaling. Int J Mol Med 28: 231-237, 2011.
APA
Cao, J., Zhu, T., Lu, L., Geng, L., Wang, L., Zhang, Q. ... Shen, W. (2011). Estrogen induces cardioprotection in male C57BL/6J mice after acute myocardial infarction via decreased activity of matrix metalloproteinase-9 and increased Akt-Bcl-2 anti-apoptotic signaling. International Journal of Molecular Medicine, 28, 231-237. https://doi.org/10.3892/ijmm.2011.681
MLA
Cao, J., Zhu, T., Lu, L., Geng, L., Wang, L., Zhang, Q., Yang, K., Wang, H., Shen, W."Estrogen induces cardioprotection in male C57BL/6J mice after acute myocardial infarction via decreased activity of matrix metalloproteinase-9 and increased Akt-Bcl-2 anti-apoptotic signaling". International Journal of Molecular Medicine 28.2 (2011): 231-237.
Chicago
Cao, J., Zhu, T., Lu, L., Geng, L., Wang, L., Zhang, Q., Yang, K., Wang, H., Shen, W."Estrogen induces cardioprotection in male C57BL/6J mice after acute myocardial infarction via decreased activity of matrix metalloproteinase-9 and increased Akt-Bcl-2 anti-apoptotic signaling". International Journal of Molecular Medicine 28, no. 2 (2011): 231-237. https://doi.org/10.3892/ijmm.2011.681
Copy and paste a formatted citation
x
Spandidos Publications style
Cao J, Zhu T, Lu L, Geng L, Wang L, Zhang Q, Yang K, Wang H and Shen W: Estrogen induces cardioprotection in male C57BL/6J mice after acute myocardial infarction via decreased activity of matrix metalloproteinase-9 and increased Akt-Bcl-2 anti-apoptotic signaling. Int J Mol Med 28: 231-237, 2011.
APA
Cao, J., Zhu, T., Lu, L., Geng, L., Wang, L., Zhang, Q. ... Shen, W. (2011). Estrogen induces cardioprotection in male C57BL/6J mice after acute myocardial infarction via decreased activity of matrix metalloproteinase-9 and increased Akt-Bcl-2 anti-apoptotic signaling. International Journal of Molecular Medicine, 28, 231-237. https://doi.org/10.3892/ijmm.2011.681
MLA
Cao, J., Zhu, T., Lu, L., Geng, L., Wang, L., Zhang, Q., Yang, K., Wang, H., Shen, W."Estrogen induces cardioprotection in male C57BL/6J mice after acute myocardial infarction via decreased activity of matrix metalloproteinase-9 and increased Akt-Bcl-2 anti-apoptotic signaling". International Journal of Molecular Medicine 28.2 (2011): 231-237.
Chicago
Cao, J., Zhu, T., Lu, L., Geng, L., Wang, L., Zhang, Q., Yang, K., Wang, H., Shen, W."Estrogen induces cardioprotection in male C57BL/6J mice after acute myocardial infarction via decreased activity of matrix metalloproteinase-9 and increased Akt-Bcl-2 anti-apoptotic signaling". International Journal of Molecular Medicine 28, no. 2 (2011): 231-237. https://doi.org/10.3892/ijmm.2011.681
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