The metabolic syndrome of fructose-fed rats: Effects of long-chain polyunsaturated ω3 and ω6 fatty acids. IV. D-glucose metabolism by isolated pancreatic islets

  • Authors:
    • Zoheir Mellouk
    • Ying Zhang
    • Nurdan Bulur
    • Karim Louchami
    • Abdullah Sener
    • Dalila Ait Yahia
    • Willy J. Malaisse
  • View Affiliations

  • Published online on: November 7, 2011     https://doi.org/10.3892/ijmm.2011.824
  • Pages: 291-293
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Abstract

The major aim of the present study was to search for changes of D-glucose metabolism in isolated pancreatic islets possibly involved in the alteration of their secretory response to the hexose, as observed when comparing rats exposed for 8 weeks to diets containing either starch and sunflower oil or fructose and sunflower oil, as well as rats exposed to diets containing fructose, sunflower oil and either salmon oil or safflower oil. The substitution of starch by fructose in the diet affected unfavourably D-glucose phosphorylation by the isolated islets. In the fructose-fed rats, there was a close parallelism between D-[5-3H]glucose utilization and the dietary ω3/ω6 fatty acid ratio. There was little to distinguish, however, between the four groups of rats in terms of D-[U-14C]glucose oxidation. The paired ratio between D-[U-14C]glucose oxidation and D-[5-3H]glucose utilization, which always increased as the concentration of the hexose was raised from 2.8 to 8.3 and 16.7 mM, was tightly related, in the fructose-fed rats, to the HOMA index for insulin resistance.

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February 2012
Volume 29 Issue 2

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Spandidos Publications style
Mellouk Z, Zhang Y, Bulur N, Louchami K, Sener A, Ait Yahia D and Malaisse W : The metabolic syndrome of fructose-fed rats: Effects of long-chain polyunsaturated ω3 and ω6 fatty acids. IV. D-glucose metabolism by isolated pancreatic islets. Int J Mol Med 29: 291-293, 2012.
APA
Mellouk, Z., Zhang, Y., Bulur, N., Louchami, K., Sener, A., Ait Yahia, D., & Malaisse, W. . (2012). The metabolic syndrome of fructose-fed rats: Effects of long-chain polyunsaturated ω3 and ω6 fatty acids. IV. D-glucose metabolism by isolated pancreatic islets. International Journal of Molecular Medicine, 29, 291-293. https://doi.org/10.3892/ijmm.2011.824
MLA
Mellouk, Z., Zhang, Y., Bulur, N., Louchami, K., Sener, A., Ait Yahia, D., Malaisse, W. ."The metabolic syndrome of fructose-fed rats: Effects of long-chain polyunsaturated ω3 and ω6 fatty acids. IV. D-glucose metabolism by isolated pancreatic islets". International Journal of Molecular Medicine 29.2 (2012): 291-293.
Chicago
Mellouk, Z., Zhang, Y., Bulur, N., Louchami, K., Sener, A., Ait Yahia, D., Malaisse, W. ."The metabolic syndrome of fructose-fed rats: Effects of long-chain polyunsaturated ω3 and ω6 fatty acids. IV. D-glucose metabolism by isolated pancreatic islets". International Journal of Molecular Medicine 29, no. 2 (2012): 291-293. https://doi.org/10.3892/ijmm.2011.824