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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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February 2012 Volume 29 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Hsp40 regulates the amount of keratin proteins via ubiquitin-proteasome pathway in cultured human cells

  • Authors:
    • Shota Yamazaki
    • Asato Uchiumi
    • Yohtaro Katagata

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Biotechnology, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki 036-8561, Japan, Department of Biochemistry and Biotechnology, Faculty of Agriculture and Life Science, Hirosaki University, 3 Bunkyocyo, Hirosaki 036-8561, Japan
  • Pages: 165-168
    |
    Published online on: November 7, 2011
       https://doi.org/10.3892/ijmm.2011.826
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Abstract

Keratins represent important structural components of intermediate filament proteins. Their expression profiles are remarkably tissue-specific. Recent data have shown that keratins associate with many proteins including heat shock proteins (HSP). We recently identified cell-specific keratin and HSP expression. We aimed to gain further insight into the regulation of keratins by specific inhibition through knockdown of Hsp40 in human keratinocyte cells. Keratin-HSP interaction in HaCaT cell lysate was evaluated by immunoprecipitation followed by Western blotting. Immunofluorescence, was used to examine the co-localization of keratins and Hsp40. Hsp40 depletion led to an increase in the levels of keratin proteins (K5, K14, K10) and a decrease in keratin ubiquitination without influencing keratin gene expression. Our results demonstrate direct or indirectly association of Hsp40 and imply that expressed keratin proteins were regulated by Hsp40 depending on the ubiquitin-proteasome pathway in HaCaT. Furthermore, the K10 differentiation marker was increased by knockdown of Hsp40. The results presented in this study indicate that Hsp40 is related to the differentiation exchange of keratin pairs.

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Copy and paste a formatted citation
Spandidos Publications style
Yamazaki S, Uchiumi A and Katagata Y: Hsp40 regulates the amount of keratin proteins via ubiquitin-proteasome pathway in cultured human cells. Int J Mol Med 29: 165-168, 2012.
APA
Yamazaki, S., Uchiumi, A., & Katagata, Y. (2012). Hsp40 regulates the amount of keratin proteins via ubiquitin-proteasome pathway in cultured human cells. International Journal of Molecular Medicine, 29, 165-168. https://doi.org/10.3892/ijmm.2011.826
MLA
Yamazaki, S., Uchiumi, A., Katagata, Y."Hsp40 regulates the amount of keratin proteins via ubiquitin-proteasome pathway in cultured human cells". International Journal of Molecular Medicine 29.2 (2012): 165-168.
Chicago
Yamazaki, S., Uchiumi, A., Katagata, Y."Hsp40 regulates the amount of keratin proteins via ubiquitin-proteasome pathway in cultured human cells". International Journal of Molecular Medicine 29, no. 2 (2012): 165-168. https://doi.org/10.3892/ijmm.2011.826
Copy and paste a formatted citation
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Spandidos Publications style
Yamazaki S, Uchiumi A and Katagata Y: Hsp40 regulates the amount of keratin proteins via ubiquitin-proteasome pathway in cultured human cells. Int J Mol Med 29: 165-168, 2012.
APA
Yamazaki, S., Uchiumi, A., & Katagata, Y. (2012). Hsp40 regulates the amount of keratin proteins via ubiquitin-proteasome pathway in cultured human cells. International Journal of Molecular Medicine, 29, 165-168. https://doi.org/10.3892/ijmm.2011.826
MLA
Yamazaki, S., Uchiumi, A., Katagata, Y."Hsp40 regulates the amount of keratin proteins via ubiquitin-proteasome pathway in cultured human cells". International Journal of Molecular Medicine 29.2 (2012): 165-168.
Chicago
Yamazaki, S., Uchiumi, A., Katagata, Y."Hsp40 regulates the amount of keratin proteins via ubiquitin-proteasome pathway in cultured human cells". International Journal of Molecular Medicine 29, no. 2 (2012): 165-168. https://doi.org/10.3892/ijmm.2011.826
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