Inhibitory effect of Trolox on the migration and invasion of human lung and cervical cancer cells

  • Authors:
    • Ho Joong Sung
    • Yoonseo Kim
    • Hyereen Kang
    • Jae Woong Sull
    • Yoon Suk Kim
    • Sung-Wuk Jang
    • Jesang Ko
  • View Affiliations

  • Published online on: Monday, November 7, 2011
  • Pages:245-251 DOI: 10.3892/ijmm.2011.832
0

Abstract

The antioxidant 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) is implicated in migration and invasion of metastatic tumors. However, the molecular mechanism underlying the effect of Trolox on metastatic cancer cells is not known. We found that a non-cytotoxic dose of Trolox decreased phorbol 12-myristate 13-acetate (PMA)-induced invasion and migration of both A549 and HeLa cancer cells. We also found that Trolox suppressed both the expression and the proteolytic activity of matrix metalloproteinase-9 (MMP-9), and that the promoter activity of PMA-induced MMP-9 was inhibited by Trolox. Our results show that Trolox inhibits the transcriptional activity of MMP-9 by suppression of NF-κB transactivation. These results indicate that Trolox inhibits NF-κB-mediated MMP-9 expression, leading to the suppression of migration and invasion in lung and cervical cancer cells. Trolox is a potential agent for clinical use in preventing the invasion and metastasis of human malignant lung and cervical cancers.

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February 2012
Volume 29 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

2015 Impact Factor: 2.348
Ranked #22/123 Medicine Research and Experimental
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APA
Sung, H. ., Kim, Y., Kang, H., Sull, J.W., Kim, Y.S., Jang, S., & Ko, J. (2012). Inhibitory effect of Trolox on the migration and invasion of human lung and cervical cancer cells. International Journal of Molecular Medicine, 29, 245-251. http://dx.doi.org/10.3892/ijmm.2011.832
MLA
Sung, H. ., Kim, Y., Kang, H., Sull, J. W., Kim, Y. S., Jang, S., Ko, J."Inhibitory effect of Trolox on the migration and invasion of human lung and cervical cancer cells". International Journal of Molecular Medicine 29.2 (2012): 245-251.
Chicago
Sung, H. ., Kim, Y., Kang, H., Sull, J. W., Kim, Y. S., Jang, S., Ko, J."Inhibitory effect of Trolox on the migration and invasion of human lung and cervical cancer cells". International Journal of Molecular Medicine 29, no. 2 (2012): 245-251. http://dx.doi.org/10.3892/ijmm.2011.832