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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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February 2012 Volume 29 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2012 Volume 29 Issue 2

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Article

Maspin increases Ku70 acetylation and Bax-mediated cell death in cancer cells

  • Authors:
    • Sook-Ja Lee
    • Haerim Jang
    • Chaehwa Park

  • View Affiliations / Copyright

    Affiliations: Cancer Genetics Laboratory, Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Republic of Korea, Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Seoul 135-710, Republic of Korea
  • Pages: 225-230
    |
    Published online on: November 10, 2011
       https://doi.org/10.3892/ijmm.2011.833
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Abstract

Ku70, a DNA repair protein, was recently identified as a critical anti-apoptotic protein that inhibits Bax translocation to mitochondria. The dissociation of Bax from Ku70 is essential for the apoptotic activity of Bax. Here, we show that maspin, a tumor suppressor protein frequently lost in cancer, regulates this process. Maspin increased cell death in a Ku70 acetylation-dependent manner. Maspin inhibited histone deacetylase 1 (HDAC1) and thus increased the acetylation of Ku70 and the dissociation of Bax from Ku70, which led to the induction of apoptosis. These results reveal maspin as a Ku70-interacting molecule and provide the basis for a new endogenous acetylation-based control mechanism that reduces Ku70-mediated sequestration of Bax from mitochondria.

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Copy and paste a formatted citation
Spandidos Publications style
Lee S, Jang H and Park C: Maspin increases Ku70 acetylation and Bax-mediated cell death in cancer cells. Int J Mol Med 29: 225-230, 2012.
APA
Lee, S., Jang, H., & Park, C. (2012). Maspin increases Ku70 acetylation and Bax-mediated cell death in cancer cells. International Journal of Molecular Medicine, 29, 225-230. https://doi.org/10.3892/ijmm.2011.833
MLA
Lee, S., Jang, H., Park, C."Maspin increases Ku70 acetylation and Bax-mediated cell death in cancer cells". International Journal of Molecular Medicine 29.2 (2012): 225-230.
Chicago
Lee, S., Jang, H., Park, C."Maspin increases Ku70 acetylation and Bax-mediated cell death in cancer cells". International Journal of Molecular Medicine 29, no. 2 (2012): 225-230. https://doi.org/10.3892/ijmm.2011.833
Copy and paste a formatted citation
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Spandidos Publications style
Lee S, Jang H and Park C: Maspin increases Ku70 acetylation and Bax-mediated cell death in cancer cells. Int J Mol Med 29: 225-230, 2012.
APA
Lee, S., Jang, H., & Park, C. (2012). Maspin increases Ku70 acetylation and Bax-mediated cell death in cancer cells. International Journal of Molecular Medicine, 29, 225-230. https://doi.org/10.3892/ijmm.2011.833
MLA
Lee, S., Jang, H., Park, C."Maspin increases Ku70 acetylation and Bax-mediated cell death in cancer cells". International Journal of Molecular Medicine 29.2 (2012): 225-230.
Chicago
Lee, S., Jang, H., Park, C."Maspin increases Ku70 acetylation and Bax-mediated cell death in cancer cells". International Journal of Molecular Medicine 29, no. 2 (2012): 225-230. https://doi.org/10.3892/ijmm.2011.833
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