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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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February 2012 Volume 29 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2012 Volume 29 Issue 2

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Article

Evaluation of the anticancer activities of thioflavanone and thioflavone in human breast cancer cell lines

  • Authors:
    • Eun Jeong Choi
    • Jae In Lee
    • Gun-Hee Kim
  • View Affiliations / Copyright

    Affiliations: Plant Resources Research Institute, Duksung Women's University, Tobong-ku, Seoul 132-714, Republic of Korea, Plant Resources Research Institute, Duksung Women's University, 419 Ssangmun-dong, Tobong-ku, Seoul 132-714, Republic of Korea
  • Pages: 252-256
    |
    Published online on: November 10, 2011
       https://doi.org/10.3892/ijmm.2011.834
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Abstract

This study investigated the anticancer effects of thioflavanone and thioflavone in the MCF-7, MDA-MB-231 and MDA-MB-453 human breast cancer cell lines. Cells were treated with either thioflavanone or thioflavone from 1 to 100 µM for 24 h, and their anti-proliferative activity and cytotoxicity was determined. Thioflavanone and thioflavone possessed similar anti-proliferative activities; their IC50 values were 62-89 and 74-128 µM, respectively, although the cytotoxicity of thioflavanone was significantly higher and occurred in a dose-dependent manner. Taken together, these results suggest that thioflavanone significantly inhibits cellular proliferation with weak cytotoxicity to a greater extent than thioflavone, and induces apoptosis in human breast cancer cell lines. Moreover, thioflavanone, but not thioflavone, induces apoptosis via p53-dependent expression of Bax.

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Copy and paste a formatted citation
Spandidos Publications style
Choi EJ, Lee JI and Kim G: Evaluation of the anticancer activities of thioflavanone and thioflavone in human breast cancer cell lines. Int J Mol Med 29: 252-256, 2012.
APA
Choi, E.J., Lee, J.I., & Kim, G. (2012). Evaluation of the anticancer activities of thioflavanone and thioflavone in human breast cancer cell lines. International Journal of Molecular Medicine, 29, 252-256. https://doi.org/10.3892/ijmm.2011.834
MLA
Choi, E. J., Lee, J. I., Kim, G."Evaluation of the anticancer activities of thioflavanone and thioflavone in human breast cancer cell lines". International Journal of Molecular Medicine 29.2 (2012): 252-256.
Chicago
Choi, E. J., Lee, J. I., Kim, G."Evaluation of the anticancer activities of thioflavanone and thioflavone in human breast cancer cell lines". International Journal of Molecular Medicine 29, no. 2 (2012): 252-256. https://doi.org/10.3892/ijmm.2011.834
Copy and paste a formatted citation
x
Spandidos Publications style
Choi EJ, Lee JI and Kim G: Evaluation of the anticancer activities of thioflavanone and thioflavone in human breast cancer cell lines. Int J Mol Med 29: 252-256, 2012.
APA
Choi, E.J., Lee, J.I., & Kim, G. (2012). Evaluation of the anticancer activities of thioflavanone and thioflavone in human breast cancer cell lines. International Journal of Molecular Medicine, 29, 252-256. https://doi.org/10.3892/ijmm.2011.834
MLA
Choi, E. J., Lee, J. I., Kim, G."Evaluation of the anticancer activities of thioflavanone and thioflavone in human breast cancer cell lines". International Journal of Molecular Medicine 29.2 (2012): 252-256.
Chicago
Choi, E. J., Lee, J. I., Kim, G."Evaluation of the anticancer activities of thioflavanone and thioflavone in human breast cancer cell lines". International Journal of Molecular Medicine 29, no. 2 (2012): 252-256. https://doi.org/10.3892/ijmm.2011.834
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