Inhibition airway remodeling and transforming growth factor-β1/Smad signaling pathway by astragalus extract in asthmatic mice

Retraction in: /10.3892/ijmm.2023.5290

  • Authors:
    • Zheng-Hai Qu
    • Zhao-Chuan Yang
    • Lei Chen
    • Zhi-Dong Lv
    • Ming-Ji Yi
    • Ni Ran
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  • Published online on: December 23, 2011     https://doi.org/10.3892/ijmm.2011.868
  • Pages: 564-568
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Abstract

Airway remodeling is characterized by airway wall thickening, subepithelial fibrosis, increased smooth muscle mass, angiogenesis and increased mucous glands, which can lead to a chronic and obstinate asthma with pulmonary function depression. In the present study, we investigated whether the astragalus extract inhibits airway remodeling in a mouse asthma model and observed the effects of astragalus extract on the transforming growth factor-β1 (TGF-β1)/Smad signaling pathway in ovalbumin-sensitized mice. Mice were sensitized and challenged by ovalbumin to establish a model of asthma. Treatments included the astragalus extract and budesonide. Lung tissues were obtained for hematoxylin and eosin staining and Periodic acid-Schiff staining after the final ovalbumin challenge. Levels of TGF-β1 were assessed by immunohistology and ELISA, levels of TGF-β1 mRNA were measured by RT-PCR, and levels of P-Smad2/3 and T-Smad2/3 were assessed by western blotting. Astragalus extract and budesonide reduced allergen-induced increases in the thickness of bronchial airway and mucous gland hypertrophy, goblet cell hyperplasia and collagen deposition. Levels of lung TGF-β1, TGF-β1 mRNA and P-Smad2/3 were significantly reduced in mice treated with astragalus extract and budesonide. Astragalus extract improved asthma airway remodeling by inhibiting the expression of the TGF-β1/Smad signaling pathway, and may be a potential drug for the treatment of patients with a severe asthma airway.
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April 2012
Volume 29 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Qu Z, Yang Z, Chen L, Lv Z, Yi M and Ran N: Inhibition airway remodeling and transforming growth factor-β1/Smad signaling pathway by astragalus extract in asthmatic mice Retraction in /10.3892/ijmm.2023.5290. Int J Mol Med 29: 564-568, 2012.
APA
Qu, Z., Yang, Z., Chen, L., Lv, Z., Yi, M., & Ran, N. (2012). Inhibition airway remodeling and transforming growth factor-β1/Smad signaling pathway by astragalus extract in asthmatic mice Retraction in /10.3892/ijmm.2023.5290. International Journal of Molecular Medicine, 29, 564-568. https://doi.org/10.3892/ijmm.2011.868
MLA
Qu, Z., Yang, Z., Chen, L., Lv, Z., Yi, M., Ran, N."Inhibition airway remodeling and transforming growth factor-β1/Smad signaling pathway by astragalus extract in asthmatic mice Retraction in /10.3892/ijmm.2023.5290". International Journal of Molecular Medicine 29.4 (2012): 564-568.
Chicago
Qu, Z., Yang, Z., Chen, L., Lv, Z., Yi, M., Ran, N."Inhibition airway remodeling and transforming growth factor-β1/Smad signaling pathway by astragalus extract in asthmatic mice Retraction in /10.3892/ijmm.2023.5290". International Journal of Molecular Medicine 29, no. 4 (2012): 564-568. https://doi.org/10.3892/ijmm.2011.868