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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
April 2012 Volume 29 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Lipid metabolic pathways as lung cancer therapeutic targets: A computational study

Kojiro Yano
Pages: 519-529
Published online on: 30 December 2011

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Article Open Access

IL-33 regulates TNF-α dependent effects in synovial fibroblasts

Elke Kunisch, Saritha Chakilam, Muktheshwar Gandesiri, Raimund W. Kinne
Pages: 530-540
Published online on: 10 January 2012

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Article Open Access

Microregional antitumor activity of a small-molecule hypoxia-inducible factor 1 inhibitor

Kiyoshi Okamoto, Daisuke Ito, Kazuki Miyazaki, Saori Watanabe, Osamu Tohyama, Akira Yokoi, Yoichi Ozawa, Makoto Asano, Takanori Kawamura, Yoshinobu Yamane, Satoshi Nagao, Setsuo Funasaka, Junichi Kamata, Yoshihiko Kotake, Mika Aoki, Naoko Tsukahara, Yoshiharu Mizui, Isao Tanaka, Kohei Sawada
Pages: 541-549
Published online on: 29 December 2011

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Article Open Access

Involvement of AMP-activated protein kinase in TGF-β-stimulated VEGF synthesis in osteoblasts

Jun Mizutani, Haruhiko Tokuda, Rie Matsushima-Nishiwaki, Kenji Kato, Akira Kondo, Hideo Natsume, Osamu Kozawa, Takanobu Otsuka
Pages: 550-556
Published online on: 23 January 2012

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Article Open Access

Resveratrol, a polyphenol phytoalexin, protects cardiomyocytes against anoxia/reoxygenation injury via the TLR4/NF-κB signaling pathway

Cui Zhang, Guosheng Lin, Weiguo Wan, Xuyon Li, Bin Zeng, Bo Yang, Congxin Huang
Pages: 557-563
Published online on: 11 January 2012

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Article

Inhibition airway remodeling and transforming growth factor-β1/Smad signaling pathway by astragalus extract in asthmatic mice Retraction in /10.3892/ijmm.2023.5290

Zheng-Hai Qu, Zhao-Chuan Yang, Lei Chen, Zhi-Dong Lv, Ming-Ji Yi, Ni Ran
Pages: 564-568
Published online on: 23 December 2011

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Article

Fibroblast growth factor 2 inhibits the expression of stromal cell-derived factor 1α in periodontal ligament cells derived from human permanent teeth in vitro

Takeyoshi Asakawa, Naoyuki Chosa, Yoshitaka Yoshimura, Asami Asakawa, Mitsuro Tanaka, Akira Ishisaki, Masato Mitome, Tomokazu Hasegawa
Pages: 569-573
Published online on: 23 December 2011

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Article

Epstein-Barr virus oncoprotein LMP1 mediates survivin upregulation by p53 contributing to G1/S cell cycle progression in nasopharyngeal carcinoma

Lili Guo, Min Tang, Lifang Yang, Lanbo Xiao, Ann M. Bode, Lili Li, Zigang Dong, Ya Cao
Pages: 574-580
Published online on: 17 January 2012

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Article

Hepatitis B virus X protein inhibits extracellular IFN-α-mediated signal transduction by downregulation of type I IFN receptor

Il-Rae Cho, Myungju Oh, Sang Seok Koh, Waraporn Malilas, Ratakorn Srisuttee, Byung Hak Jhun, Sandra Pellegrini, Serge Y. Fuchs, Young-Hwa Chung
Pages: 581-586
Published online on: 03 January 2012

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Article

Nanog and β-catenin: A new convergence point in EpSC proliferation and differentiation

Delong Yin, Linqiang Tian, Yaping Ye, Kunpeng Li, Jiang Wang, Peng Cheng, Anmin Chen, Fengjing Guo, Hui Huang
Pages: 587-592
Published online on: 29 December 2011

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Article

Niacin protects against UVB radiation-induced apoptosis in cultured human skin keratinocytes

Fuquan Lin, Wen Xu, Cuiping Guan, Miaoni Zhou, Weisong Hong, Lifang Fu, Dongyin Liu, Aie Xu
Pages: 593-600
Published online on: 12 January 2012

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Article

miR-200b is involved in intestinal fibrosis of Crohn's disease

Yingwei Chen, Wensong Ge, Leiming Xu, Chunying Qu, Mingjie Zhu, Wenzhu Zhang, Yongtao Xiao
Pages: 601-606
Published online on: 23 January 2012

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Article

Antiproliferative effect of alpinetin in BxPC-3 pancreatic cancer cells Corrigendum in /10.3892/ijmm.2023.5303

Jian Du, Bo Tang, Jingwen Wang, Hongtao Sui, Xueli Jin, Liming Wang, Zhongyu Wang
Pages: 607-612
Published online on: 11 January 2012

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Article

ERK and Akt signaling pathways are involved in advanced glycation end product-induced autophagy in rat vascular smooth muscle cells

Pengfei Hu, Dongwu Lai, Peilin Lu, Jing Gao, Hong He
Pages: 613-618
Published online on: 23 January 2012

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Article

Cilostazol induces cellular senescence and confers resistance to etoposide-induced apoptosis in articular chondrocytes

Kang Mi Kim, Jong Min Kim, Young Hyun Yoo, Jeung Il Kim, Young Chul Park
Pages: 619-624
Published online on: 23 January 2012

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Article

Kanglaite attenuates UVB-induced down-regulation of aquaporin-3 in cultured human skin keratinocytes

Shi-Jun Shan, Ting Xiao, John Chen, Shi-Ling Geng, Chang-Ping Li, Xuegang Xu, Yuxiao Hong, Chao Ji, Ying Guo, Huachen Wei, Wei Liu, Dapeng Li, Hong-Duo Chen
Pages: 625-629
Published online on: 29 December 2011

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Article

The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway

Tao Chen, Lei Zhang, Yan Qu, Kai Huo, XiaoFan Jiang, Zhou Fei
Pages: 630-636
Published online on: 28 December 2011

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Article

Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism

Aftab Ali Shah, Petra Leidinger, Andreas Keller, Anke Wendschlag, Eckart Meese, Nikolaus Blin
Pages: 637-643
Published online on: 10 January 2012

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Article

Novel RS1 mutations associated with X-linked juvenile retinoschisis

Junhui Yi, Shiqiang Li, Xiaoyun Jia, Xueshan Xiao, Panfeng Wang, Xiangming Guo, Qingjiong Zhang
Pages: 644-648
Published online on: 10 January 2012

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Article

Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells

Feng-Hou Gao, Feng Liu, Wei Wei, Li-Bin Liu, Mang-Hua Xu, Zhu-Ying Guo, Wei Li, Bin Jiang, Ying-Li Wu
Pages: 649-655
Published online on: 24 January 2012

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Article

Pattern of cancer/testis antigen expression in lung cancer patients

Yeong-Dae Kim, Hae-Rim Park, Myung-Ha Song, Dong-Hoon Shin, Chang-Hun Lee, Min-Ki Lee, Sang-Yull Lee
Pages: 656-662
Published online on: 24 January 2012

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Article

The regulatory role of microRNA-1187 in TNF-α-mediated hepatocyte apoptosis in acute liver failure

Dong Shan Yu, Fang Mei An, Bang Dong Gong, Xiao Gang Xiang, Lan Yi Lin, Hui Wang, Qing Xie
Pages: 663-668
Published online on: 17 January 2012

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Article

Analysis of the coding sequence and expression of the coiled-coil α-helical rod protein 1 gene in normal and neoplastic epithelial cervical cells

Joanna Pacholska-Bogalska, Magdalena Myga-Nowak, Katarzyna Ciepłuch, Agata Józefiak, Anna Kwaśniewska, Anna Goździcka-Józefiak
Pages: 669-676
Published online on: 03 January 2012

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Article

Cloning of the surface layer gene sllB from Bacillus sphaericus ATCC 14577 and its heterologous expression and purification

Yu-Bao Cui, Ying Zhou, Wei-Na Liu, Qing-Wen Chen, Gui-Fang Ma, Wei-Hong Shi, Yun-Gang Wang, Li Yang
Pages: 677-682
Published online on: 19 January 2012

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Article

Females with angina pectoris have altered lipoprotein metabolism with elevated cholesteryl ester transfer protein activity and impaired high-density lipoproteins-associated antioxidant enzymes

Jungho Park, Jae-Ryong Kim, Dong-Gu Shin, Kyung-Hyun Cho
Pages: 683-689
Published online on: 29 December 2011

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Article

Alternative splicing of apoptosis-related genes in imatinib-treated K562 cells identified by exon array analysis

Jing Liu, Yun Xiao, Huo-Mei Xiong, Jing Li, Bo Huang, Hai-Bin Zhang, Dan-Qin Feng, Xi-Min Chen, Xiao-Zhong Wang
Pages: 690-698
Published online on: 29 December 2011

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Article

NOD1 and NOD2 stimulation triggers innate immune responses of human periodontal ligament cells

Do-In Jeon, Se-Ra Park, Mee-Young Ahn, Sang-Gun Ahn, Jong-Hwan Park, Jung-Hoon Yoon
Pages: 699-703
Published online on: 03 January 2012

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Article

Protocadherin-10 is involved in angiogenesis and methylation correlated with multiple myeloma

Ying Li, Ze-song Yang, Jun-jun Song, Qiong Liu, Jian-bin Chen
Pages: 704-710
Published online on: 09 January 2012

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Article

Soybean glyceollins mitigate inducible nitric oxide synthase and cyclooxygenase-2 expression levels via suppression of the NF-κB signaling pathway in RAW 264.7 cells

Eun-Kyung Yoon, Hyun-Kyoung Kim, Song Cui, Yong-Hoon Kim, Sang-Han Lee
Pages: 711-717
Published online on: 12 January 2012

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Journal Cover
May-2026 Volume 57 Issue 5

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Macrophage SH3 domain‑containing GRB2‑like protein B1 is required for Rab7‑mediated mitophagy in inflammation during sea water drowning acute lung injury

Hongjuan Ning, Jingyu Deng, Yongheng Gao, Wei Zhang, Jian Chen, Xian Guo, Faguang Jin
Article Number: 138
Published online on: 24 March 2026

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Article Open Access

Deferoxamine mitigates neuronal loss following spinal cord injury via ferroptosis inhibition and Nrf2/HO‑1 pathway activation

Ziqian Ma, Xinwei Zhang, Tao Liu, Yan Zhang, Guanghao Li, Xin Yuan, Benqiang Tang, Hangyi Zhao, Liang Liu, Xueming Chen
Article Number: 137
Published online on: 23 March 2026

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Review Open Access

USP10 deubiquitinase: Physiological function, diseases and therapeutic target (Review)

Linlin Zhang, Huajing Sun, Zifan Wang, Zhimei Wang, Qiang Mu, Yukun Liu
Article Number: 136
Published online on: 23 March 2026

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Siglec‑15 dysregulation and its therapeutic implications in new‑onset type 1 diabetes 

Heming Guo, Yunwen Tao, Sicheng Li, Ying Gu, Yiting Huang, Chen Fang, Ji Hu
Article Number: 135
Published online on: 20 March 2026

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ZEB1 maintains mitochondrial fission and macrophage efferocytosis by restraining MFN2, thereby limiting inflammation and improving tendon‑bone healing

Yan Zhao, Yuankai Zhang, Tian Lei, Shangqing Zhang, Kai Nan, Xin Zhang, Li-Hong Fan
Article Number: 134
Published online on: 19 March 2026

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Review Open Access

Targeting pyroptosis in renal fibrosis: From molecular mechanisms to therapeutic horizons (Review)

Yihuai Tian, Quwu Mushuo, Hui Fan, Hongwei Su, Jianchun Li, Qiong Zhang
Article Number: 133
Published online on: 19 March 2026

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Expression of Concern Open Access

[Expression of Concern] Fasudil, a Rho‑associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats

Haishan Song, Dianwen Gao
Article Number: 132
Published online on: 18 March 2026

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Epigenetic regulation in a high-sugar environment (Review)

Huili Zhou, Xinhe Lv, Yu Liang, Dehai Yu, Wanning Wang
Article Number: 131
Published online on: 17 March 2026

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The roles and heterogeneity of CD8+ T cells in inflammatory bowel disease: A narrative review of insights from single‑cell transcriptomics (Review)

Rui Zhong, Jing Guo, Wujie Ye, Zhihui Deng, Huangan Wu, Qin Qi, Guona Li, Lu Zhu, Yan Huang, Luyi Wu
Article Number: 130
Published online on: 17 March 2026

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Mechanism of action and clinical application of autophagy in multiple sclerosis (Review)

Dongmei Wang, Qizhi Fu, Ying Zhao, Guangda Li, Yongjie Bai, Yang Yang, Hongna Song, Mingwei Wang, Hua Fan
Article Number: 129
Published online on: 17 March 2026

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[Expression of Concern] Insulin‑dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation

Mamiko Hie, Natsumi Iitsuka, Tomoyo Otsuka, Ikuyo Tsukamoto
Article Number: 128
Published online on: 16 March 2026

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Mechanotransduction and its impact on regenerative medicine in orthopedic rehabilitation (Review)

Baohui Wang, Xueqin Zeng, Huajian Liu, Liang Li, Tao Lei, Yafeng Li, Qing Fang, Yi Cao, Bo Dong
Article Number: 127
Published online on: 13 March 2026

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Article Open Access

4‑Acetylantrocamol LT3 suppresses colorectal cancer growth and metastasis via PI3K/AKT and MAPK pathway modulation

Kuen-Tze Lin, Yu-Chieh Hsieh, Pi-Kai Chang, Chih-Wei Lai, Shih-Yu Lee, I-Chuan Yen
Article Number: 126
Published online on: 13 March 2026

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Roles of ubiquitin‑specific peptidase 22 in cellular fate: From embryonic survival to tissue repair, inflammation and metabolism (Review)

Jia-Nan Xiang, Chen-Yang Zhou, Yu-Di Zhao, Xiao Xu, Sun-Bin Ling
Article Number: 125
Published online on: 12 March 2026

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m6A in adipose tissue inflammation: A novel regulator of obesity and metabolic diseases (Review)

Xiaoting Yang, Xiaodan Wang, Haojun Tang, Shuangxi Tu, Kai Yin, Xiao Zhu
Article Number: 124
Published online on: 12 March 2026

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Expression of Concern Open Access

[Expression of Concern] Visfatin/PBEF/Nampt induces EMMPRIN and MMP‑9 production in macrophages via the NAMPT‑MAPK (p38, ERK1/2)‑NF‑κB signaling pathway

Yuqi Fan, Shu Meng, Yue Wang, Jiatian Cao, Changqian Wang
Article Number: 123
Published online on: 12 March 2026

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Article Open Access

IL‑37/IL‑1R8 blocks keratinocyte acantholysis via suppressing ADAM17/EGFR

Fengxia Hu, Wenjing Chen, Qian Wang, Xiaoyu Zhang, Fuyang Xiao, Jinying Zhang, Junqin Liang
Article Number: 122
Published online on: 12 March 2026

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Reactive oxygen species in fetal growth restriction mechanisms and therapeutic directions (Review)

Di Cheng, Songbin Yang, Cuilan Wang, Kefeng Fan, Fengchun Gao, Qian Sun
Article Number: 121
Published online on: 12 March 2026

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Research progress on the molecular mechanisms of tanshinone IIA in the treatment of cardiovascular and cerebrovascular diseases (Review)

Wen Pei, Ping Lu, Chenhuan Ding, Ying Li, Yong Li
Article Number: 120
Published online on: 12 March 2026

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Ferritin in ferroptosis: Implications for neurodegenerative diseases (Review)

Wenjing Chen, Heng Tian, Ran Wei, Xiaomei Chen, Yiwen Jia
Article Number: 119
Published online on: 12 March 2026

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Correction Open Access

[Corrigendum] Ursolic acid protects against cisplatin‑induced ototoxicity by inhibiting oxidative stress and TRPV1‑mediated Ca2+‑signaling  

Yang Di, Tao Xu, Yuan Tian, Tingting Ma, Donghao Qu, Yan Wang, Yuhan Lin, Dongyan Bao, Li Yu, Shuangyue Liu, Aimei Wang
Article Number: 118
Published online on: 09 March 2026

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Article Open Access

HELLS inhibits autophagy‑dependent ferroptosis in nasopharyngeal carcinoma by modulating the Nrf2/HO‑1/GPX4 pathway

Chengxun Jin, Jinqiu Li, Siqi Han, Chaoluomeng Bai, Jingpu Yang, Zonggui Wang
Article Number: 117
Published online on: 09 March 2026

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Expression of Concern Open Access

[Expression of Concern] Inhibitory effect of curcumin on angiogenesis in ectopic endometrium of rats with experimental endometriosis

Ying Zhang, Hong Cao, Yue-Yue Hu, Hua Wang, Chang-Jun Zhang
Article Number: 116
Published online on: 09 March 2026

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Article Open Access

Propofol upregulates MFG‑E8 in BV2 cells to inhibit pyroptosis mediated by the NF‑κB/NLRP3 pathway, thereby ameliorating ischemic‑reperfusion neuronal injury

Shewei Guo, Yingwei Zhen, Guosheng Zhou, Zhihua Zhao
Article Number: 115
Published online on: 05 March 2026

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Article Open Access

Exosomal circ0000549 promotes MNNG‑induced gastric cancer through miR‑15b‑5p/KIF1B

Zhaofeng Liang, Zihan Gao, Yue Zhang, Jiajia Song, Hui Qian, Xuezhong Xu
Article Number: 114
Published online on: 04 March 2026

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Expression of Concern Open Access

[Expression of Concern] Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy  

Fangfang Li, Ning Zhang, Qingqing Wu, Yuan Yuan, Zheng Yang, Mengqiao Zhou, Jinxiu Zhu, Qizhu Tang
Article Number: 113
Published online on: 04 March 2026

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Review Open Access

Treatment of pulmonary fibrosis: From disease mechanisms to future novel therapies (Review)

Sen Lu, Yunfei Liu, Xiaohua Li, Qipeng Yao
Article Number: 112
Published online on: 03 March 2026

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Review Open Access

Research progress in single‑cell omics technologies for kidney disease (Review)

Jia Xu, Ziwei Chen, Shengyao Li, Xiaoya Wang, Ming Chen
Article Number: 111
Published online on: 03 March 2026

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Review Open Access

CLDN7: Epithelial gatekeeper from physiology to pathology‑roles in cancer and epithelial‑related diseases (Review)

Xiuping Lai, Yan Yan, Lu Sun, Zili Lei, Yanhong Yang
Article Number: 110
Published online on: 03 March 2026

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Dynamic regulation and targeted intervention of neutrophils in hepatic ischemia‑reperfusion injury (Review)

Sen Lu, Jiale Tong, Jing Jiang, Qin Zhang, Youjin Huang
Article Number: 109
Published online on: 03 March 2026

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Review Open Access

The dual role of the crosstalk between autophagy and ferroptosis in lung cancer treatment: Advances in mechanisms and therapeutic strategies (Review)

Yingying Zhang, Ruxin Shen
Article Number: 108
Published online on: 02 March 2026

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Review Open Access

Mechanistic insights into inflammatory cytokines in adenomyosis‑induced infertility (Review)

Bojiao Yang, Feng Li, Guimao Cao, Mingtu Nuo, Yaxin Shi, Zilu Wang, Jing Jia, Wei Shi, Zhiyong Liu
Article Number: 107
Published online on: 02 March 2026

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Correction Open Access

[Corrigendum] Astragaloside IV promotes the proliferation and migration of osteoblast‑like cells through the hedgehog signaling pathway

Li-Hua Guo, Yu Cao, Run-Tao Zhuang, Yan Han, Jun Li
Article Number: 106
Published online on: 02 March 2026

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June-2026 Volume 57 Issue 6

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Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Crosstalk between autophagy and ferroptosis in liver diseases (Review)

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Article Number: 142
Published online on: 26 March 2026

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circOMA1 delivered by exosomes regulates DRD2‑mediated prolactinoma resistance

Qing Rao, Dimin Zhu, Zongming Wang, Shaolin Zhang, Xueli Li, Shashikiran Tagilapalli, Nan Wang, Weiyu Hu, Wenli Chen, Yonghong Zhu
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Published online on: 26 March 2026

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Expression of Concern Open Access

[Expression of Concern] Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells

Jian-Jun Xie, Li-Yan Xu, Yang-Min Xie, Ze-Peng Du, Cai-Hua Feng, Hui Dong, En-Min Li
Article Number: 140
Published online on: 24 March 2026

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Article Open Access

Novel Hsp90 inhibitor JD‑02 inhibits HSV‑1 infection via the Raf/MEK/ERK signaling pathway

Yexuan Zhu, Xiaohui Wang, Jiaying Lin, Xiao Wang, Kai Zheng, Zhe Ren, Ji Xiao, Yifei Wang
Article Number: 139
Published online on: 24 March 2026

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