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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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April 2012 Volume 29 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Nanog and β-catenin: A new convergence point in EpSC proliferation and differentiation

  • Authors:
    • Delong Yin
    • Linqiang Tian
    • Yaping Ye
    • Kunpeng Li
    • Jiang Wang
    • Peng Cheng
    • Anmin Chen
    • Fengjing Guo
    • Hui Huang

  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
  • Pages: 587-592
    |
    Published online on: December 29, 2011
       https://doi.org/10.3892/ijmm.2011.871
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Abstract

Skin tissue homeostasis is maintained by the balanced proliferation and differentiation of certain types of proliferating cells such as epidermal stem cells (EpSCs). The proliferation and differentiation of EpSCs are complex processes which are not well understood. This study aimed to find the internal relationship between the Nanog pathway and the Wnt/β-catenin pathway in the proliferation and differentiation process of EpSCs. In brief, EpSCs were isolated from rat epidermis and cultured. The MTT assay, western blotting, polymerase chain reaction (PCR) and immunocytochemistry were performed during the proliferation and differentiation process of EpSCs. Our results showed that 10-7 M neuropeptide substance P could effectively stimulate proliferation of EpSCs and that a possible link exists between the Nanog pathway and the Wnt/β-catenin pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Yin D, Tian L, Ye Y, Li K, Wang J, Cheng P, Chen A, Guo F and Huang H: Nanog and β-catenin: A new convergence point in EpSC proliferation and differentiation. Int J Mol Med 29: 587-592, 2012.
APA
Yin, D., Tian, L., Ye, Y., Li, K., Wang, J., Cheng, P. ... Huang, H. (2012). Nanog and β-catenin: A new convergence point in EpSC proliferation and differentiation. International Journal of Molecular Medicine, 29, 587-592. https://doi.org/10.3892/ijmm.2011.871
MLA
Yin, D., Tian, L., Ye, Y., Li, K., Wang, J., Cheng, P., Chen, A., Guo, F., Huang, H."Nanog and β-catenin: A new convergence point in EpSC proliferation and differentiation". International Journal of Molecular Medicine 29.4 (2012): 587-592.
Chicago
Yin, D., Tian, L., Ye, Y., Li, K., Wang, J., Cheng, P., Chen, A., Guo, F., Huang, H."Nanog and β-catenin: A new convergence point in EpSC proliferation and differentiation". International Journal of Molecular Medicine 29, no. 4 (2012): 587-592. https://doi.org/10.3892/ijmm.2011.871
Copy and paste a formatted citation
x
Spandidos Publications style
Yin D, Tian L, Ye Y, Li K, Wang J, Cheng P, Chen A, Guo F and Huang H: Nanog and β-catenin: A new convergence point in EpSC proliferation and differentiation. Int J Mol Med 29: 587-592, 2012.
APA
Yin, D., Tian, L., Ye, Y., Li, K., Wang, J., Cheng, P. ... Huang, H. (2012). Nanog and β-catenin: A new convergence point in EpSC proliferation and differentiation. International Journal of Molecular Medicine, 29, 587-592. https://doi.org/10.3892/ijmm.2011.871
MLA
Yin, D., Tian, L., Ye, Y., Li, K., Wang, J., Cheng, P., Chen, A., Guo, F., Huang, H."Nanog and β-catenin: A new convergence point in EpSC proliferation and differentiation". International Journal of Molecular Medicine 29.4 (2012): 587-592.
Chicago
Yin, D., Tian, L., Ye, Y., Li, K., Wang, J., Cheng, P., Chen, A., Guo, F., Huang, H."Nanog and β-catenin: A new convergence point in EpSC proliferation and differentiation". International Journal of Molecular Medicine 29, no. 4 (2012): 587-592. https://doi.org/10.3892/ijmm.2011.871
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