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International Journal of Molecular Medicine
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Article

Kanglaite attenuates UVB-induced down-regulation of aquaporin-3 in cultured human skin keratinocytes

  • Authors:
    • Shi-Jun Shan
    • Ting Xiao
    • John Chen
    • Shi-Ling Geng
    • Chang-Ping Li
    • Xuegang Xu
    • Yuxiao Hong
    • Chao Ji
    • Ying Guo
    • Huachen Wei
    • Wei Liu
    • Dapeng Li
    • Hong-Duo Chen
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Tianjin Medical University General Hospital, Tianjin, P.R. China, Department of Dermatology, The No. 1 Hospital of China Medical University, Shenyang 110001, P.R. China, Dermatology Associates, Tucson, AZ, USA, Department of Dermatology, Heihe People Hospital, Heihe, Heilongjiang, P.R. China, Department of Health Statistics, College of Public Health, Tianjin Medical University, Tianjin, P.R. China, Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China, Ackerman Academy of Dermatopathology, New York, NY, USA, Dermatology Research Laboratories, Department of Dermatology, The Mount Sinai Medical Center, New York, NY, USA, Department of Dermatology, Air Force General Hospital, Beijing, P.R. China, Zhejiang Kanglaite Pharmaceutical Co., Ltd., Hangzhou, Zhejiang, P.R. China
  • Pages: 625-629
    |
    Published online on: December 29, 2011
       https://doi.org/10.3892/ijmm.2011.873
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Abstract

Ultraviolet (UV) radiation plays an important role in the pathogenesis of skin photoaging. Depending on the wavelength of UV, the epidermis is affected primarily by UVB. One major characteristic of photoaging is the dehydration of the skin. Membrane-inserted water channels (aquaporins) are involved in this process. In this study we demonstrated that UVB radiation induced aquaporin-3 (AQP3) down-regulation in cultured human skin keratinocytes. Kanglaite is a mixture consisting of extractions of Coix Seed, which is an effective anti-neoplastic agent and can inhibit the activities of protein kinase C and NF-κB. We demonstrated that Kanglaite inhibited UVB-induced AQP3 down-regulation of cultured human skin keratinocytes. Our findings provide a potential new agent for anti-photoaging. The related molecular mechanisms remain to be further elucidated.
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Copy and paste a formatted citation
Spandidos Publications style
Shan S, Xiao T, Chen J, Geng S, Li C, Xu X, Hong Y, Ji C, Guo Y, Wei H, Wei H, et al: Kanglaite attenuates UVB-induced down-regulation of aquaporin-3 in cultured human skin keratinocytes. Int J Mol Med 29: 625-629, 2012.
APA
Shan, S., Xiao, T., Chen, J., Geng, S., Li, C., Xu, X. ... Chen, H. (2012). Kanglaite attenuates UVB-induced down-regulation of aquaporin-3 in cultured human skin keratinocytes. International Journal of Molecular Medicine, 29, 625-629. https://doi.org/10.3892/ijmm.2011.873
MLA
Shan, S., Xiao, T., Chen, J., Geng, S., Li, C., Xu, X., Hong, Y., Ji, C., Guo, Y., Wei, H., Liu, W., Li, D., Chen, H."Kanglaite attenuates UVB-induced down-regulation of aquaporin-3 in cultured human skin keratinocytes". International Journal of Molecular Medicine 29.4 (2012): 625-629.
Chicago
Shan, S., Xiao, T., Chen, J., Geng, S., Li, C., Xu, X., Hong, Y., Ji, C., Guo, Y., Wei, H., Liu, W., Li, D., Chen, H."Kanglaite attenuates UVB-induced down-regulation of aquaporin-3 in cultured human skin keratinocytes". International Journal of Molecular Medicine 29, no. 4 (2012): 625-629. https://doi.org/10.3892/ijmm.2011.873
Copy and paste a formatted citation
x
Spandidos Publications style
Shan S, Xiao T, Chen J, Geng S, Li C, Xu X, Hong Y, Ji C, Guo Y, Wei H, Wei H, et al: Kanglaite attenuates UVB-induced down-regulation of aquaporin-3 in cultured human skin keratinocytes. Int J Mol Med 29: 625-629, 2012.
APA
Shan, S., Xiao, T., Chen, J., Geng, S., Li, C., Xu, X. ... Chen, H. (2012). Kanglaite attenuates UVB-induced down-regulation of aquaporin-3 in cultured human skin keratinocytes. International Journal of Molecular Medicine, 29, 625-629. https://doi.org/10.3892/ijmm.2011.873
MLA
Shan, S., Xiao, T., Chen, J., Geng, S., Li, C., Xu, X., Hong, Y., Ji, C., Guo, Y., Wei, H., Liu, W., Li, D., Chen, H."Kanglaite attenuates UVB-induced down-regulation of aquaporin-3 in cultured human skin keratinocytes". International Journal of Molecular Medicine 29.4 (2012): 625-629.
Chicago
Shan, S., Xiao, T., Chen, J., Geng, S., Li, C., Xu, X., Hong, Y., Ji, C., Guo, Y., Wei, H., Liu, W., Li, D., Chen, H."Kanglaite attenuates UVB-induced down-regulation of aquaporin-3 in cultured human skin keratinocytes". International Journal of Molecular Medicine 29, no. 4 (2012): 625-629. https://doi.org/10.3892/ijmm.2011.873
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