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Article

Females with angina pectoris have altered lipoprotein metabolism with elevated cholesteryl ester transfer protein activity and impaired high-density lipoproteins-associated antioxidant enzymes

  • Authors:
    • Jungho Park
    • Jae-Ryong Kim
    • Dong-Gu Shin
    • Kyung-Hyun Cho
  • View Affiliations / Copyright

    Affiliations: School of Biotechnology, Yeungnam University, Gyeongsan 712-749, Rebublic of Korea, Department of Biochemistry and Molecular Biology, Aging-associated Vascular Disease Research Center, Yeungnam University, Daegu 705-717, Republic of Korea, Cardiovascular Division, Internal Medicine, Aging-associated Vascular Disease Research Center, Yeungnam University Medical Center, Daegu 705-717, Republic of Korea
  • Pages: 683-689
    |
    Published online on: December 29, 2011
       https://doi.org/10.3892/ijmm.2011.874
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Abstract

In order to investigate non-invasive biomarkers for angina pectoris (AP), we analyzed the lipid and protein composition in individual lipoproteins from females with angina pectoris (n=22) and age- and gender-matched controls (n=20). In the low-density lipoprotein (LDL) fraction, the triglycerides (TG) and protein content increased in the AP group compared to the control group. The AP group had lower total cholesterol (TC) and elevated TG in the high-density lipoprotein (HDL) fraction. In the AP group, cholesteryl ester transfer protein (CETP) activity was enhanced in HDL and LDL, while lecithin:cholesterol acyltransferase (LCAT) activity in HDL3 was almost depleted. Antioxidant activity was significantly decreased in the HDL3 fraction, with a decrease in the HDL2 particle size. In the HDL3 fraction, paraoxonase and platelet activating factor-acetylhydrolase (PAF-AH) activity were much lower and the levels of CETP and apoC-III were elevated in the AP group. The LDL from the AP group was more sensitive to cupric ion-mediated oxidation with faster mobility. In conclusion, the lipoprotein fractions in the AP group had impaired antioxidant activity and increased TG and apoC-III with structural and functional changes.
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Copy and paste a formatted citation
Spandidos Publications style
Park J, Kim J, Shin D and Cho K: Females with angina pectoris have altered lipoprotein metabolism with elevated cholesteryl ester transfer protein activity and impaired high-density lipoproteins-associated antioxidant enzymes. Int J Mol Med 29: 683-689, 2012.
APA
Park, J., Kim, J., Shin, D., & Cho, K. (2012). Females with angina pectoris have altered lipoprotein metabolism with elevated cholesteryl ester transfer protein activity and impaired high-density lipoproteins-associated antioxidant enzymes. International Journal of Molecular Medicine, 29, 683-689. https://doi.org/10.3892/ijmm.2011.874
MLA
Park, J., Kim, J., Shin, D., Cho, K."Females with angina pectoris have altered lipoprotein metabolism with elevated cholesteryl ester transfer protein activity and impaired high-density lipoproteins-associated antioxidant enzymes". International Journal of Molecular Medicine 29.4 (2012): 683-689.
Chicago
Park, J., Kim, J., Shin, D., Cho, K."Females with angina pectoris have altered lipoprotein metabolism with elevated cholesteryl ester transfer protein activity and impaired high-density lipoproteins-associated antioxidant enzymes". International Journal of Molecular Medicine 29, no. 4 (2012): 683-689. https://doi.org/10.3892/ijmm.2011.874
Copy and paste a formatted citation
x
Spandidos Publications style
Park J, Kim J, Shin D and Cho K: Females with angina pectoris have altered lipoprotein metabolism with elevated cholesteryl ester transfer protein activity and impaired high-density lipoproteins-associated antioxidant enzymes. Int J Mol Med 29: 683-689, 2012.
APA
Park, J., Kim, J., Shin, D., & Cho, K. (2012). Females with angina pectoris have altered lipoprotein metabolism with elevated cholesteryl ester transfer protein activity and impaired high-density lipoproteins-associated antioxidant enzymes. International Journal of Molecular Medicine, 29, 683-689. https://doi.org/10.3892/ijmm.2011.874
MLA
Park, J., Kim, J., Shin, D., Cho, K."Females with angina pectoris have altered lipoprotein metabolism with elevated cholesteryl ester transfer protein activity and impaired high-density lipoproteins-associated antioxidant enzymes". International Journal of Molecular Medicine 29.4 (2012): 683-689.
Chicago
Park, J., Kim, J., Shin, D., Cho, K."Females with angina pectoris have altered lipoprotein metabolism with elevated cholesteryl ester transfer protein activity and impaired high-density lipoproteins-associated antioxidant enzymes". International Journal of Molecular Medicine 29, no. 4 (2012): 683-689. https://doi.org/10.3892/ijmm.2011.874
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