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Article

Endogenous glucocorticoids promote the expansion of myeloid-derived suppressor cells in a murine model of trauma

  • Authors:
    • Kun Zhang
    • Xiangjun Bai
    • Renjie Li
    • Zhengzheng Xiao
    • Jiajun Chen
    • Fan Yang
    • Zhanfei Li
  • View Affiliations / Copyright

    Affiliations: Department of Trauma Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China, Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China
  • Pages: 277-282
    |
    Published online on: May 29, 2012
       https://doi.org/10.3892/ijmm.2012.1014
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Abstract

Stress-dose of glucocorticoid has been demonstrated to be beneficial for trauma patients in clinical studies. Recently, a heterogeneous population of myeloid cells with immunosuppressive activity named myeloid-derived suppressor cells (MDSCs) has been found to accumulate in the trauma host and can be induced by glucocorticoids in vitro. In order to explore the effect of endogenous glucocorticoids on MDSCs under trauma conditions, we blocked the glucocorticoid signal in a murine trauma model using the antagonist of the glucocorticoid receptor RU486 (mifepristone). We found for the first time that RU486 not only blunted MDSC expansion induced by trauma in the spleen, peripheral blood and bone marrow especially at 6 h after traumatic stress but also decreased the survival rate from 100 to 20% in traumatic mice within 7 days. Moreover, neither MDSCs producing arginase-1 nor the morphological characterization of trauma-induced MDSCs was affected by the blockage of the glucocorticoid receptor. Our results suggest that endogenous glucocorticoids may promote MDSCs expansion in a murine trauma model and MDSCs may be beneficial for the trauma host.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang K, Bai X, Li R, Xiao Z, Chen J, Yang F and Li Z: Endogenous glucocorticoids promote the expansion of myeloid-derived suppressor cells in a murine model of trauma. Int J Mol Med 30: 277-282, 2012.
APA
Zhang, K., Bai, X., Li, R., Xiao, Z., Chen, J., Yang, F., & Li, Z. (2012). Endogenous glucocorticoids promote the expansion of myeloid-derived suppressor cells in a murine model of trauma. International Journal of Molecular Medicine, 30, 277-282. https://doi.org/10.3892/ijmm.2012.1014
MLA
Zhang, K., Bai, X., Li, R., Xiao, Z., Chen, J., Yang, F., Li, Z."Endogenous glucocorticoids promote the expansion of myeloid-derived suppressor cells in a murine model of trauma". International Journal of Molecular Medicine 30.2 (2012): 277-282.
Chicago
Zhang, K., Bai, X., Li, R., Xiao, Z., Chen, J., Yang, F., Li, Z."Endogenous glucocorticoids promote the expansion of myeloid-derived suppressor cells in a murine model of trauma". International Journal of Molecular Medicine 30, no. 2 (2012): 277-282. https://doi.org/10.3892/ijmm.2012.1014
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang K, Bai X, Li R, Xiao Z, Chen J, Yang F and Li Z: Endogenous glucocorticoids promote the expansion of myeloid-derived suppressor cells in a murine model of trauma. Int J Mol Med 30: 277-282, 2012.
APA
Zhang, K., Bai, X., Li, R., Xiao, Z., Chen, J., Yang, F., & Li, Z. (2012). Endogenous glucocorticoids promote the expansion of myeloid-derived suppressor cells in a murine model of trauma. International Journal of Molecular Medicine, 30, 277-282. https://doi.org/10.3892/ijmm.2012.1014
MLA
Zhang, K., Bai, X., Li, R., Xiao, Z., Chen, J., Yang, F., Li, Z."Endogenous glucocorticoids promote the expansion of myeloid-derived suppressor cells in a murine model of trauma". International Journal of Molecular Medicine 30.2 (2012): 277-282.
Chicago
Zhang, K., Bai, X., Li, R., Xiao, Z., Chen, J., Yang, F., Li, Z."Endogenous glucocorticoids promote the expansion of myeloid-derived suppressor cells in a murine model of trauma". International Journal of Molecular Medicine 30, no. 2 (2012): 277-282. https://doi.org/10.3892/ijmm.2012.1014
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