Immunohistochemical analysis of TGF-β1 and VEGF in gingival and periodontal tissues: A role of these biomarkers in the pathogenesis of scleroderma and periodontal disease

Matarese,Giovanni; Isola,Gaetano; Anastasi,Giuseppe  Pio; Favaloro,Angelo; Milardi,Demetrio; Vermiglio,Giovanna; Vita,Giuseppe; Cordasco,Giancarlo; Cutroneo,Giuseppina

doi:10.3892/ijmm.2012.1024

Immunohistochemical analysis of TGF-β1 and VEGF in gingival and periodontal tissues: A role of these biomarkers in the pathogenesis of scleroderma and periodontal disease

Authors:
- Giovanni Matarese
- Gaetano Isola
- Giuseppe Pio Anastasi
- Angelo Favaloro
- Demetrio Milardi
- Giovanna Vermiglio
- Giuseppe Vita
- Giancarlo Cordasco
- Giuseppina Cutroneo
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Affiliations: Department of Odontostomatology, School of Dentistry, University of Messina, Messina, Italy, Department of Orthodontic and Gnathology-Masticatory Function, School of Orthodontics, University of Turin, Turin, Italy, Department of Biomorphology and Biotechnologies, University of Messina, Messina, Italy, Unit of Tissue Typing, Department of Pathology and Experimental Microbiology, University of Messina, Messina, Italy
Published online on: June 11, 2012 https://doi.org/10.3892/ijmm.2012.1024
Pages: 502-508

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Abstract

Periodontal disease is characterized by inflammation and bone loss. The balance between inflammatory mediators and their counter-regulatory molecules may be fundamental for determining the outcome of the immune pathology of periodontal disease. Transforming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF) represent a family of polypeptide proteins involved in the inflammation and regulation of immune responses, especially in rheumatic disease. The relationship between these growth factors and periodontitis has resulted in a new field of osteoimmunology and provides a context for better understanding the pathogenesis of periodontal disease. Therefore, the aim of this study was to compare the protein expression profile of these inflammatory mediators in 90 patients divided in three groups: healthy control, chronic periodontitis and in rheumatic disease, scleroderma. The findings presented here highlight that biomarkers, such as TGF-β1 and VEGF, play a key role in the evolution of the immune response, which in turn influences the outcome of disease establishment.

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