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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
September 2012 Volume 30 Issue 3

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

In vitro and in vivo properties of a fully human IgG1 monoclonal antibody that combats multidrug resistant Pseudomonas aeruginosa

Azmi Adawi, Carlo Bisignano, Tiziana Genovese, Angela Filocamo, Camellia Khouri-Assi, Anat Neville, Giora Z. Feuerstein, Salvatore Cuzzocrea, Lewis F. Neville
Pages: 455-464
Published online on: 20 June 2012

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Article Open Access

Targeting of the anti-apoptotic gene survivin in human thyroid carcinoma

Zhouxun Chen, Naxin Liu, Guanbao Zhu, Henning Dralle, Cuong Hoang-Vu
Pages: 465-472
Published online on: 28 June 2012

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Article Open Access

Silymarin suppresses hepatic stellate cell activation in a dietary rat model of non-alcoholic steatohepatitis: Αnalysis of isolated hepatic stellate cells

Mina Kim, Su-Geun Yang, Joon Mi Kim, Jin-Woo Lee, Young Soo Kim, Jung Il Lee
Pages: 473-479
Published online on: 14 June 2012

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Article Open Access

Establishment of immortalized Schwann cells derived from rat embryo dorsal root ganglia

Huajun Jiang, Wei Qu, Feng Han, Dazhuang Liu, Weiguo Zhang
Pages: 480-486
Published online on: 06 June 2012

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Article Open Access

A mechanism underlying the effects of polyunsaturated fatty acids on breast cancer

Hao Zhang, Lei Zhou, Wei Shi, Ning Song, Karu Yu, Yuchun Gu
Pages: 487-494
Published online on: 11 June 2012

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Article

The basic helix-loop-helix transcription factor DEC2 inhibits TGF-β-induced tumor progression in human pancreatic cancer BxPC-3 cells

Fuyuki Sato, Haruka Kawamura, Yunyan Wu, Hiroyasu Sato, Daiki Jin, Ujjal Kumar Bhawal, Takeshi Kawamoto, Katsumi Fujimoto, Mitsuhide Noshiro, Hiroko Seino, Satomo Morohashi, Yukio Kato, Hiroshi Kijima
Pages: 495-501
Published online on: 19 June 2012

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Article

Immunohistochemical analysis of TGF-β1 and VEGF in gingival and periodontal tissues: A role of these biomarkers in the pathogenesis of scleroderma and periodontal disease

Giovanni Matarese, Gaetano Isola, Giuseppe Pio Anastasi, Angelo Favaloro, Demetrio Milardi, Giovanna Vermiglio, Giuseppe Vita, Giancarlo Cordasco, Giuseppina Cutroneo
Pages: 502-508
Published online on: 11 June 2012

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Article

Temporal change in IL-6 mRNA and protein expression produced by cyclic stretching of human pulmonary artery endothelial cells

Kozue Kobayashi, Masumi Tanaka, Satoru Nebuya, Kenichi Kokubo, Yutaka Fukuoka, Yoshiteru Harada, Hirouske Kobayashi, Makoto Noshiro, Hidenori Inaoka
Pages: 509-513
Published online on: 11 June 2012

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Article

siRNA-based targeting of fractalkine overexpression suppresses inflammation development in a severe acute pancreatitis rat model

Liya Huang, Junwen Ma, Yuming Tang, Ping Chen, Shuxian Zhang, Yongping Zhang, Yao Zong Yuan
Pages: 514-520
Published online on: 29 June 2012

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Article

Mutation screening of TRPM1, GRM6, NYX and CACNA1F genes in patients with congenital stationary night blindness

Qin Wang, Yang Gao, Shiqiang Li, Xiangming Guo, Qingjiong Zhang
Pages: 521-526
Published online on: 20 June 2012

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Article

Therapeutic potential of bone marrow-derived mesenchymal stem cells producing pigment epithelium-derived factor in lung carcinoma

Qiaoling Chen, Ping Cheng, Tao Yin, Hong He, Li Yang, Yuquan Wei, Xiancheng Chen
Pages: 527-534
Published online on: 06 June 2012

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Article

Evaluation of the genetic variability of human papillomavirus type 52

Qiang Chen, Zhao-Yun Luo, Min Lin, Lin Yang, Li-Ye Yang, Gui-Zhi Ju
Pages: 535-544
Published online on: 06 June 2012

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Article

Interferon-γ deficiency reduces neointimal formation in a model of endoluminal endothelial injury combined with atherogenic diet

Nasim Nik Tavakoli, Angie K. Harris, David R. Sullivan, Brett D. Hambly, Shisan Bao
Pages: 545-552
Published online on: 15 June 2012

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Article

Interleukin-13 peptide kinoid vaccination attenuates allergic inflammation in a mouse model of asthma

Qiuping Jing, Tao Yin, Yang Wan, Huashan Shi, Shuntao Luo, Meng Li, Hailong Zhang, Hong He, Shijia Liu, Haoyu Li, Yuquan Wei, Li Yang
Pages: 553-560
Published online on: 19 June 2012

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Article

LPS-induced iNOS expression in N9 microglial cells is suppressed by geniposide via ERK, p38 and nuclear factor-κB signaling pathways

Gu Zhang, Jun-Lin He, Xiao-Yan Xie, Chao Yu
Pages: 561-568
Published online on: 14 June 2012

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Article

Reduction of protein kinase MARK4 in the brains of experimental scrapie rodents and human prion disease correlates with deposits of PrPSc

Han-Shi Gong, Yan Guo, Chan Tian, Wu-Ling Xie, Qi Shi, Jin Zhang, Yin Xu, Shao-Bin Wang, Bao-Yun Zhang, Cao Chen, Yong Liu, Xiao-Ping Dong
Pages: 569-578
Published online on: 12 June 2012

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Article

Damage of hair follicle stem cells and alteration of keratin expression in external radiation-induced acute alopecia

Naoki Nanashima, Koichi Ito, Takashi Ishikawa, Manabu Nakano, Toshiya Nakamura
Pages: 579-584
Published online on: 11 June 2012

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Article

A study of the anti-diabetic agents of camel milk

Ajamaluddin Malik, Abdulrahman Al-Senaidy, Ewa Skrzypczak-Jankun, Jerzy Jankun
Pages: 585-592
Published online on: 29 June 2012

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Article

Enhancing apoptotic cell clearance mitigates bacterial translocation and promotes tissue repair after gut ischemia-reperfusion injury

Rongqian Wu, Weifeng Dong, Zhimin Wang, Asha Jacob, Tianpen Cui, Ping Wang
Pages: 593-598
Published online on: 26 June 2012

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Article

Local delivery of recombinant adenovirus expressing hepatitis B virus X protein and interleukin-12 results in antitumor effects via inhibition of hepatoma cell growth and intervention of tumor microenvironment

Hong He, Ping Fan, Tao Yin, Qiaoling Chen, Huashan Shi, Sijia Liu, Haoyu Li, Qiuping  Jing, Yingying Yan, Hailong Zhang, Li Yang, Yanjun Wen, Yuhua Li, Ping Cheng
Pages: 599-605
Published online on: 12 June 2012

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Article

Grape skin and loquat leaf extracts and acai puree have potent anti-atherosclerotic and anti-diabetic activity in vitro and in vivo in hypercholesterolemic zebrafish

Jae-Yong Kim, Joo-Heon Hong, Hee Kyoung Jung, Yoo Seok Jeong, Kyung-Hyun Cho
Pages: 606-614
Published online on: 28 June 2012

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Article

Characterization of IK cytokine expression in mouse endometrium during early pregnancy and its significance on implantation

Ruyue Shao, Xueqing Liu, Yubin Ding, Xuemei Chen, Rufei Gao, Junlin He, Yingxiong Wang
Pages: 615-621
Published online on: 11 June 2012

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Article

Effect of visfatin on the function of endothelial progenitor cells in high-fat-fed obese rats and investigation of its mechanism of action

Yang Sun, Shuchun Chen, Guangyao Song, Luping Ren, Limin Wei, Na Liu, Donemei Zhang, Xiuqin Lv
Pages: 622-628
Published online on: 14 June 2012

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Article

Hexavalent chromium targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent caspase-3 activation in L-02 hepatocytes

Fang Xiao, Yanhong Li, Lu Dai, Yuanyuan Deng, Yue Zou, Peng Li, Yuan Yang, Caigao Zhong
Pages: 629-635
Published online on: 14 June 2012

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Article

Wnt3a inhibits proliferation but promotes melanogenesis of melan-a cells

Haiying Guo, Ke Yang, Fang Deng, Yizhan Xing, Yuhong Li, Xiaohua Lian, Tian Yang
Pages: 636-642
Published online on: 14 June 2012

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Article

Curcumin ameliorates mitochondrial dysfunction associated with inhibition of gluconeogenesis in free fatty acid-mediated hepatic lipoapoptosis

Jong-Jen Kuo, Hen-Hong Chang, Tung-Hu Tsai, Tzung-Yan Lee
Pages: 643-649
Published online on: 11 June 2012

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Article

Effect of the IGF-1/PTEN/Akt/FoxO signaling pathway on the development and healing of water immersion and restraint stress-induced gastric ulcers in rats

Pan Huang, Zhengrong Zhou, Hao Wang, Quanwei Wei, Liang Zhang, Xin Zhou, Reinhold J. Hutz, Fangxiong Shi
Pages: 650-658
Published online on: 20 June 2012

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Article

Lentivirus-mediated expression of Drosophila melanogaster deoxyribonucleoside kinase driven by the hTERT promoter combined with gemcitabine: A potential strategy for cancer therapy

Nianqu Zhang, Lei Zhao, Shuai Ma, Ming Gu, Xinyu Zheng
Pages: 659-665
Published online on: 14 June 2012

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Article

TGF-β1 and IGF-1 influence the re-differentiation capacity of human chondrocytes in 3D pellet cultures in relation to different oxygen concentrations

Anika Jonitz, Katrin Lochner, Thomas Tischer, Doris Hansmann, Rainer Bader
Pages: 666-672
Published online on: 25 June 2012

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Article

Positive effect of curcumin on inflammation and mitochondrial dysfunction in obese mice with liver steatosis

Jong-Jen Kuo, Hen-Hong Chang, Tung-Hu Tsai, Tzung-Yan Lee
Pages: 673-679
Published online on: 29 June 2012

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Article

Decreased serum miR-181a is a potential new tool for breast cancer screening

Li-Juan Guo, Qing-Yun Zhang
Pages: 680-686
Published online on: 11 June 2012

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Article

Effects of chronic cocaine in rat C6 astroglial cells

Ramesh B. Badisa, Carl B. Goodman
Pages: 687-692
Published online on: 20 June 2012

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Article

Identification of ankylosing spondylitis-associated genes by expression profiling

Hui Ma, Dabo Xu, Qiang Fu
Pages: 693-696
Published online on: 28 June 2012

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Article

Role of NLRP3 and CARD8 in the regulation of TNF-α induced IL-1β release in vascular smooth muscle cells

Tebeng Nixon Tangi, Ali Ateia Elmabsout, Torbjörn Bengtsson, Allan Sirsjö, Karin Fransén
Pages: 697-702
Published online on: 12 June 2012

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Article

Effects on inflammatory responses by the sphingoid base 4,8-sphingadienine

Evelien Rozema, Markus Binder, Murty Bulusu, Valery Bochkov, Georg Krupitza, Brigitte Kopp
Pages: 703-707
Published online on: 15 June 2012

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Article

The bone anabolic carotenoid p-hydroxycinnamic acid promotes osteoblast mineralization and suppresses osteoclast differentiation by antagonizing NF-κB activation

Masayoshi Yamaguchi, M. Neale Weitzmann
Pages: 708-712
Published online on: 26 June 2012

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Article

A novel mutation of exon 7 in growth hormone receptor mRNA in a patient with growth hormone insensitivity syndrome and neurofibromatosis type I

Ju-Hyung Kang, Ok-Soon Kim, Ja-Hyun Kim, Seong-Kyu Lee, Youn-Jong Park, Haing-Woon Baik
Pages: 713-717
Published online on: 28 June 2012

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Journal Cover
August-2026 Volume 58 Issue 2

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 231
Published online on: 24 June 2026

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Review Open Access

Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review)

Kebing Lv, Zijie Ma, Qiuni Chen, Yang Su, Jingjing Ma, Chunling Wang, Liang Yu
Article Number: 230
Published online on: 23 June 2026

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Recombinant myonectin ameliorates sepsis‑induced cardiomyopathy by alleviating mitochondrial dysfunction via the AdipoR1/AMPK pathway

Peipei Li, Rui Chen, Hanmo Zhang, Lihong Li, Huiling Luo, Beibei Du, Ping Yang
Article Number: 229
Published online on: 23 June 2026

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MTA2: Decoding pathogenic mechanisms, clinical implications and therapeutic frontiers across disease landscapes (Review)

Hao Xie, Ling Chen, Jing Gou, Xuehong Long, Ya Yang, Hai Hu, Ping Wu, Qibing Yan, Yongkang Wu
Article Number: 228
Published online on: 22 June 2026

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Mitochondria‑endoplasmic reticulum contact site nexus: Molecular integration, disease pathogenesis and therapeutic opportunities (Review)

Yi Liu, Xianda Che, Wei Wei, Chong Teng, Huimin Li
Article Number: 227
Published online on: 22 June 2026

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Metabolic messengers from the gut to the joint: Toward precision management of osteoarthritis (Review)

Ruipu Zhang, Liang Zhang, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 226
Published online on: 22 June 2026

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Retraction Open Access

[Retracted] Protection of telomeres 1 protein levels are associated with telomere length in gastric cancer

Kiyomu Fujii, Tomonori Sasahira, Yukiko Moriwaka, Naohide Oue, Wataru Yasui, Hiroki Kuniyasu
Article Number: 225
Published online on: 22 June 2026

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Molecular mechanism of hydromorphone preconditioning in cerebral ischemia/reperfusion‑induced inflammatory injury

Jing Yao, Zeqing Huang, Songze Li, Minghui Lun, Jianing Fan
Article Number: 224
Published online on: 18 June 2026

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Oridonin ameliorates ulcerative colitis by regulating the PI3K/AKT/mTOR signaling pathway to activate autophagy

Zhongxing Miao, Baohong Liu, Xingzhi Zhou, Mengru Lu, Ni Jia, Huamin Zhang, Ying Qi, Xiaoyu Tan, Qinggao Zhang
Article Number: 223
Published online on: 18 June 2026

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Article

Arsenic exposure and skin cancer: Mechanisms, clinical evidence and public health implications (Review)

Dimitrios A. Andreikos, Michael Aschner, Dimitrios C. Ziogas, Aristidis Tsatsakis, Demetrios A. Spandidos
Article Number: 222
Published online on: 18 June 2026

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Targeting glutathione metabolism for tumor radiosensitization (Review)

Haonan Xu, Meng Du, Xiaowen Liang, Xilin Xiao, Zhiyi Chen
Article Number: 221
Published online on: 16 June 2026

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Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review)

Xinxin Zhang, Biao Zhang
Article Number: 220
Published online on: 15 June 2026

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Article Open Access

Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis

Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang
Article Number: 219
Published online on: 12 June 2026

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Correction Open Access

[Corrigendum] (‑)‑Epigallocatechin‑3‑gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions

Yang Wu, Zhong-Yuan Xia, Bo Zhao, Yan Leng, Juan Dou, Qing-Tao Meng, Shao-Qing Lei, Zhi-Ze Chen, Jie Zhu
Article Number: 218
Published online on: 10 June 2026

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Article Open Access

Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis

Qingtao Yang, Wei Li, Qi Yu, Jiang Shi, Lu Yang, Jun Qiao, Xi Wei, Changshi Gu, Fa Sun, Tao Li
Article Number: 217
Published online on: 09 June 2026

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Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review)

Yaping Wu, Hao Yu, Ling Xia, Li Yang, Yu Zhou, Qian Yu
Article Number: 216
Published online on: 08 June 2026

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Review Open Access

Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review)

Boying Zhu, Chaoyang Wang, Peng Liu, Zhifeng Qu, Ran Qi, Shengjiang Chen, Huanzhang Niu
Article Number: 215
Published online on: 08 June 2026

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Article Open Access

Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress

Miao Xue, Junshuai Feng, Xiaorong Mao
Article Number: 214
Published online on: 08 June 2026

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Retraction Open Access

[Retracted] Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

Lang Li, Liang Dong, Dan Zhao, Fei Gao, Jie Yan
Article Number: 213
Published online on: 08 June 2026

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Review Open Access

Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review)

Wei Dai, Jiabin Wu, Xiaotong Ma, Mingyu Wu, Ke Li, Haoyang Gao, Wenhong Wang, Weihua Xiao
Article Number: 212
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Review Open Access

Functional hydrogels in cardiovascular therapy: Design, applications and clinical challenges (Review)

Zheming Yang, Jiayin Li, Lingxiao Zhao, Dali Zhang, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 211
Published online on: 04 June 2026

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Review Open Access

Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review)

Stefanny M. Figueroa, Siyi Huang, Javier Reyes‑Osorio, Jean-Jacques Boffa, Cristián A. Amador, Christos E. Chadjichristos, Louis Boutin
Article Number: 210
Published online on: 04 June 2026

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Expression of Concern Open Access

[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2  cardiac myocytes

Zhanli Yang, Chuntao Yang, Liangcan Xiao, Xinxue Liao, Aiping Lan, Xiuyu Wang, Ruixian Guo, Peixi Chen, Chengheng Hu, Jianqiang Feng
Article Number: 209
Published online on: 03 June 2026

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Article Open Access

Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
Article Number: 208
Published online on: 03 June 2026

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Article Open Access

Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu
Article Number: 207
Published online on: 02 June 2026

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Retraction Open Access

[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert

Xiaoxu Gao, Yan Cai, Ruifang An
Article Number: 206
Published online on: 02 June 2026

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Review

Multi‑scale experimental models for the study of angiogenesis (Review)

Qin Yu, Jiarui Hu, Shuangshuang Yuan, Jiexia Gan, Mao Luo, Jianbo Wu, Liqun Wang
Article Number: 205
Published online on: 28 May 2026

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Review Open Access

Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

Lianting Chen, Feiqiong Gao, Qianru Mei, Yujie Li, Qun Cai, Xudong Feng
Article Number: 204
Published online on: 28 May 2026

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Article Open Access

Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Jianwei Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Gean Wu, Zhen Hua
Article Number: 203
Published online on: 28 May 2026

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Journal Cover
September-2026 Volume 58 Issue 3

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

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