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Article

Interleukin-13 peptide kinoid vaccination attenuates allergic inflammation in a mouse model of asthma

  • Authors:
    • Qiuping Jing
    • Tao Yin
    • Yang Wan
    • Huashan Shi
    • Shuntao Luo
    • Meng Li
    • Hailong Zhang
    • Hong He
    • Shijia Liu
    • Haoyu Li
    • Yuquan Wei
    • Li Yang
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, P.R. China, School of Life Science, Sichuan University, Chengdu, Sichuan, P.R. China
  • Pages: 553-560
    |
    Published online on: June 19, 2012
       https://doi.org/10.3892/ijmm.2012.1036
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Abstract

Asthma is an atopic disorder with increasing frequency and severity in developed nations. Interleukin-13 (IL-13) is one of the most critical mediators of asthma pathology. In the present study, we developed a vaccine comprised of a keyhole limpet hemocyanin-mIL-13 heterocomplex immunogen to persistently neutralize excessive endogenous IL-13. Our results showed that the IL-13 peptide kinoid vaccine could induce sustained and high titer of IL-13-specific IgG when using aluminum hydroxide as an adjuvant, and could suppress the accumulation of eosinophils as well as IL-13 levels in bronchoalveolar lavage fluid (BALF). In addition, total IgE and ovalbumin (OVA)-specific IgE in serum were significantly inhibited. This study also showed that vaccination could prevent airway inflammation and epithelial cell proliferation with goblet cell hyperplasia in a mouse model of acute asthma. In summary, our findings suggest that the IL-13 peptide kinoid can serve as an innovative and effective vaccine against asthma.
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Copy and paste a formatted citation
Spandidos Publications style
Jing Q, Yin T, Wan Y, Shi H, Luo S, Li M, Zhang H, He H, Liu S, Li H, Li H, et al: Interleukin-13 peptide kinoid vaccination attenuates allergic inflammation in a mouse model of asthma. Int J Mol Med 30: 553-560, 2012.
APA
Jing, Q., Yin, T., Wan, Y., Shi, H., Luo, S., Li, M. ... Yang, L. (2012). Interleukin-13 peptide kinoid vaccination attenuates allergic inflammation in a mouse model of asthma. International Journal of Molecular Medicine, 30, 553-560. https://doi.org/10.3892/ijmm.2012.1036
MLA
Jing, Q., Yin, T., Wan, Y., Shi, H., Luo, S., Li, M., Zhang, H., He, H., Liu, S., Li, H., Wei, Y., Yang, L."Interleukin-13 peptide kinoid vaccination attenuates allergic inflammation in a mouse model of asthma". International Journal of Molecular Medicine 30.3 (2012): 553-560.
Chicago
Jing, Q., Yin, T., Wan, Y., Shi, H., Luo, S., Li, M., Zhang, H., He, H., Liu, S., Li, H., Wei, Y., Yang, L."Interleukin-13 peptide kinoid vaccination attenuates allergic inflammation in a mouse model of asthma". International Journal of Molecular Medicine 30, no. 3 (2012): 553-560. https://doi.org/10.3892/ijmm.2012.1036
Copy and paste a formatted citation
x
Spandidos Publications style
Jing Q, Yin T, Wan Y, Shi H, Luo S, Li M, Zhang H, He H, Liu S, Li H, Li H, et al: Interleukin-13 peptide kinoid vaccination attenuates allergic inflammation in a mouse model of asthma. Int J Mol Med 30: 553-560, 2012.
APA
Jing, Q., Yin, T., Wan, Y., Shi, H., Luo, S., Li, M. ... Yang, L. (2012). Interleukin-13 peptide kinoid vaccination attenuates allergic inflammation in a mouse model of asthma. International Journal of Molecular Medicine, 30, 553-560. https://doi.org/10.3892/ijmm.2012.1036
MLA
Jing, Q., Yin, T., Wan, Y., Shi, H., Luo, S., Li, M., Zhang, H., He, H., Liu, S., Li, H., Wei, Y., Yang, L."Interleukin-13 peptide kinoid vaccination attenuates allergic inflammation in a mouse model of asthma". International Journal of Molecular Medicine 30.3 (2012): 553-560.
Chicago
Jing, Q., Yin, T., Wan, Y., Shi, H., Luo, S., Li, M., Zhang, H., He, H., Liu, S., Li, H., Wei, Y., Yang, L."Interleukin-13 peptide kinoid vaccination attenuates allergic inflammation in a mouse model of asthma". International Journal of Molecular Medicine 30, no. 3 (2012): 553-560. https://doi.org/10.3892/ijmm.2012.1036
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