TGF-β1 and IGF-1 influence the re-differentiation capacity of human chondrocytes in 3D pellet cultures in relation to different oxygen concentrations

J FarrB ColeA DhawanJ KercherS ShermanClinical cartilage restoration: evolution and overviewClin Orthop Relat Res46926962705201110.1007/s11999-010-1764-z21240578

RF LoeserAging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrixOsteoarthritis Cartilage17971979200910.1016/j.joca.2009.03.00219303469

S GiovanniniJ Diaz-RomeroT AignerP HeiniP Mainil-VarletD NesicMicromass co-culture of human articular chondrocytes and human bone marrow mesenchymal stem cells to investigate stable neocartilage tissue formation in vitroEur Cell Mater202452592010

L PetersonHS VasiliadisM BrittbergA LindahlAutologous chondrocyte implantation: a long-term follow-upAm J Sports Med3811171124201010.1177/036354650935791520181804

DG StokesG LiuR DharmavaramD HawkinsS Piera-VelazquezSA JimenezRegulation of type-II collagen gene expression during human chondrocyte de-differentiation and recovery of chondrocyte-specific phenotype in culture involves Sry-type high-mobility-group box (SOX) transcription factorsBiochem J360461470200110.1042/0264-6021:3600461

PD BenyaJD ShafferDedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gelsCell30215224198210.1016/0092-8674(82)90027-77127471

J BonaventureN KadhomL Cohen-SolalKH NgJ BourguignonC LasselinP FreisingerReexpression of cartilage-specific genes by dedifferentiated human articular chondrocytes cultured in alginate beadsExp Cell Res21297104199410.1006/excr.1994.11238174647

PM van der KraanP BumaKT vanWB van den BergInteraction of chondrocytes, extracellular matrix and growth factors: relevance for articular cartilage tissue engineeringOsteoarthritis Cartilage10631637200212479385

S ChubinskayaA HakimiyanC PacioneA YankeL RappoportT AignerDC RuegerRF LoeserSynergistic effect of IGF-1 and OP-1 on matrix formation by normal and OA chondrocytes cultured in alginate beadsOsteoarthritis Cartilage15421430200710.1016/j.joca.2006.10.00417126570

P GiannoniR CanceddaArticular chondrocyte culturing for cell-based cartilage repair: needs and perspectivesCells Tissues Organs184115200610.1159/00009694617190975

T FukumotoJW SperlingA SanyalJS FitzsimmonsGG ReinholzCA ConoverSW O’DriscollCombined effects of insulin-like growth factor-1 and transforming growth factor-beta1 on periosteal mesenchymal cells during chondrogenesis in vitroOsteoarthritis Cartilage115564200310.1053/joca.2002.086912505488

PC YaegerTL MasiJL de OrtizF BinetteR TuboJM McPhersonSynergistic action of transforming growth factor-beta and insulin-like growth factor-I induces expression of type II collagen and aggrecan genes in adult human articular chondrocytesExp Cell Res237318325199710.1006/excr.1997.3781

GJ van OschSW van der VeenP BumaHL Verwoerd-VerhoefEffect of transforming growth factor-beta on proteoglycan synthesis by chondrocytes in relation to differentiation stage and the presence of pericellular matrixMatrix Biol1741342419989840443

A JonitzK LochnerK PetersA SalamonJ PasoldB Mueller-HilkeD HansmannR BaderDifferentiation capacity of human chondrocytes embedded in alginate matrixConnect Tissue Res52503511201110.3109/03008207.2011.59367321787134

PA GuerneF BlancoA KaelinA DesgeorgesM LotzGrowth factor responsiveness of human articular chondrocytes in aging and developmentArthritis Rheum38960968199510.1002/art.17803807127612045

L ZhangP SuC XuJ YangW YuD HuangChondrogenic differentiation of human mesenchymal stem cells: a comparison between micromass and pellet culture systemsBiotechnol Lett3213391346201010.1007/s10529-010-0293-x20464452

JE LafontLack of oxygen in articular cartilage: consequences for chondrocyte biologyInt J Exp Pathol9199106201010.1111/j.1365-2613.2010.00707.x20384821

J BohenskySP TerkhornTA FreemanCS AdamsJA GarciaIM ShapiroV SrinivasRegulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagyArthritis Rheum6014061415200910.1002/art.2444419404942

JA TylerInsulin-like growth factor 1 can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokinesBiochem J26054354819892788408

TI MoralesThe insulin-like growth factor binding proteins in uncultured human cartilage: increases in insulin-like growth factor binding protein 3 during osteoarthritisArthritis Rheum4623582367200210.1002/art.10482

D PfanderK GelseHypoxia and osteoarthritis: how chondrocytes survive hypoxic environmentsCurr Opin Rheumatol19457462200710.1097/BOR.0b013e3282ba569317762611

E SchipaniPosttranslational modifications of collagens as targets of hypoxia and Hif-1alpha in endochondral bone developmentAnn NY Acad Sci1192317321201010.1111/j.1749-6632.2009.05236.x20392253

E DuvalS LeclercqJM ElissaldeM DemoorP GaleraK BoumedieneHypoxia-inducible factor 1alpha inhibits the fibroblast-like markers type I and type II collagen during hypoxia-induced chondrocyte redifferentiation: hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type II collagen in the hypoxia-inducible factor 1alpha-dependent redifferentiation of chondrocytesArthritis Rheum60303830482009

JA MartinBA MillerMB ScherbLA LembkeJA BuckwalterCo-localization of insulin-like growth factor binding protein 3 and fibronectin in human articular cartilageOsteoarthritis Cartilage10556563200210.1053/joca.2002.079112127836

C GonzalezKG Auw YangJH SchwabJS FitzsimmonsMM ReinholzZT ReschLK BaleVR ClemensCA ConoverSW O’DriscollGG ReinholzTransforming growth factor-beta1 modulates insulin-like growth factor binding protein-4 expression and proteolysis in cultured periosteal explantsGrowth Horm IGF Res208186201010.1016/j.ghir.2009.06.00219656700