Identification of ankylosing spondylitis-associated genes by expression profiling

Ma,Hui; Xu,Dabo; Fu,Qiang

doi:10.3892/ijmm.2012.1047

September 2012 Volume 30 Issue 3

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September 2012 Volume 30 Issue 3

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Article

Identification of ankylosing spondylitis-associated genes by expression profiling

Authors:
- Hui Ma
- Dabo Xu
- Qiang Fu
View Affiliations / Copyright

Affiliations: Department of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, P.R. China
Pages: 693-696
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Published online on: June 28, 2012

https://doi.org/10.3892/ijmm.2012.1047
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Abstract

Ankylosing spondylitis (AS) is a chronic inflammation attacking the sacroiliac joints and the spine. Certain genes have been associated with the occurrence of AS. Gene chip data were utilized to recognize genes associated with AS for the association of the clinical diagnosis and the biomedical study. Microarray expression data of AS were acquired from the public microarray database GEO (gene expression omnibus), and AS-related genes were obtained by differential gene expression profiling. The transcriptional and translational levels of these genes were further examined. The transcriptional and translational levels of three genes were shown to be upregulated in a mouse model of AS by real-time PCR and Elisa assay, respectively. Differential expression of AS-related genes was identified by analysis of gene chip data, contributing to the advancement of the understanding of the pathogenesis of AS.

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1.	S AssassiJD ReveilleFC ArnettWhole-blood gene expression profiling in ankylosing spondylitis shows upregulation of Toll-like receptor 4 and 5J Rheumatol388798201110.3899/jrheum.10046920952467
2.	YY GuoLL YangHD CuiS ZhaoN ZhangCoexisting ankylosing spondylitis and rheumatoid arthritis: a case report with literature reviewChin Med J (Engl)12434303432201122088550
3.	HS HowePL CheungKO KongTransforming growth factor beta-1 and gene polymorphisms in oriental ankylosing spondylitisRheumatology445154200510.1093/rheumatology/keh42615479754
4.	TH KimWS UhmRD InmanPathogenesis of ankylosing spondylitis and reactive arthritisCurr Opin Rheumatol17400405200510.1097/01.bor.0000163447.44037.c415956835
5.	DJV SpencerThe involvement of HLA-B27 in ankylosing spondylitisMedicine (SCJMM)684892005
6.	B SzalayG MeszarosA CsehAdaptive immunity in ankylosing spondylitis: phenotype and functional alterations of T-cells before and during infliximab therapyClin Dev Immunol2012808724201210.1155/2012/80872421969839
7.	RA GeorgeJY LiuLL FengRJ Bryson-RichardsonD FatkinMA WoutersAnalysis of protein sequence and interaction data for candidate disease gene predictionNucleic Acids Res34e130200610.1093/nar/gkl70717020920
8.	MA OosterwegelRJ GreenwaldDA MandelbrotRB LorsbachAH SharpeCTLA-4 and T cell activationCurr Opin Immunol11294300199910.1016/S0952-7915(99)80047-810375557
9.	K TakatsuInterleukin 5 and B cell differentiationCytokine Growth Factor Rev92535199810.1016/S1359-6101(97)00034-8
10.	E BruynsA Marie-CardineH KirchgessnerT cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intra-cellular signaling proteins to the plasma membraneJ Exp Med188561575199810.1084/jem.188.3.561
11.	W ZhangLE SamelsonThe role of membrane-associated adaptors in T cell receptor signallingSemin Immunol123541200010.1006/smim.2000.020510723796

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Identification of ankylosing spondylitis-associated genes by expression profiling

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