Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
October 2012 Volume 30 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October 2012 Volume 30 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Guggulsterone inhibits melanogenesis in B16 murine melanoma cells by downregulating tyrosinase expression

  • Authors:
    • Jeung-Hyun Koo
    • Kyoung-Suk Rhee
    • Hyoung-Won Koh
    • Hyun-Young Jang
    • Byung-Hyun Park
    • Jin-Woo Park
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-756, Republic of Korea, Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-756, Republic of Korea
  • Pages: 974-978
    |
    Published online on: July 12, 2012
       https://doi.org/10.3892/ijmm.2012.1057
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In the present study, we investigated the effect of guggulsterone on melanogenesis in B16 melanoma cells and elucidated its possible mechanism of action. The effects of guggulsterone on melanogenesis were determined by assaying melanin synthesis and cellular tyrosinase activity in B16/F10 mouse melanoma cells. Guggulsterone dose-dependently inhibited isobutylmethylxanthine (IBMX)-induced melanogenesis and cellular tyrosinase activity with no cytotoxicity. Decreased melanin biosynthesis was accompanied by the reduced expression of melanogenesis-related genes, such as tyrosinase, microphthalmia-associated transcription factor, tyrosinase-related protein (TRP)-1 and TRP-2. Guggulsterone also inhibited α-melanocyte stimulating hormone- or forskolin-induced increases in melanogenesis, suggesting an action on the cAMP-dependent melanogenic pathway. Co-incubation with chenodeoxycholic acid, a well-known farnesoid-X receptor agonist, did not affect IBMX-induced melanogenesis. These results suggest that guggulsterone exerts a melanogenic inhibitory effect through the downregulation of tyrosinase expression.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1. 

Y YamaguchiVJ HearingPhysiological factors that regulate skin pigmentationBiofactors35193199200910.1002/biof.2919449448

2. 

VJ HearingM JimenezMammalian tyrosinase - the critical regulatory control point in melanocyte pigmentationInt J Biochem1911411147198710.1016/0020-711X(87)90095-43125075

3. 

K YokoyamaK YasumotoH SuzukiS ShibaharaCloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expressionJ Biol Chem26927080270871994

4. 

T KobayashiK UrabeA WinderTyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesisEMBO J135818582519947813420

5. 

GE CostinVJ HearingHuman skin pigmentation: melanocytes modulate skin color in response to stressFASEB J21976994200710.1096/fj.06-6649rev17242160

6. 

R BuscaR BallottiCyclic AMP a key messenger in the regulation of skin pigmentationPigment Cell Res136069200010.1034/j.1600-0749.2000.130203.x10841026

7. 

S ImO MoroF PengActivation of the cyclic AMP pathway by alpha-melanotropin mediates the response of human melanocytes to ultraviolet B radiationCancer Res58475419989426056

8. 

C BertolottoP AbbeTJ HemesathMicrophthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytesJ Cell Biol142827835199810.1083/jcb.142.3.8279700169

9. 

P WanY HuL HeRegulation of melanocyte pivotal transcription factor MITF by some other transcription factorsMol Cell Biochem354241246201110.1007/s11010-011-0823-421519923

10. 

CJ SinalFJ GonzalezGuggulsterone: an old approach to a new problemTrends Endocrinol Metab13275276200210.1016/S1043-2760(02)00640-912163224

11. 

NL UrizarDD MooreGUGULIPID: a natural cholesterol-lowering agentAnnu Rev Nutr23303313200310.1146/annurev.nutr.23.011702.07310212626688

12. 

NL UrizarAB LivermanDT DoddsA natural product that lowers cholesterol as an antagonist ligand for FXRScience29617031706200210.1126/science.107289111988537

13. 

J WuC XiaJ MeierS LiX HuDS LalaThe hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptorMol Endocrinol1615901597200210.1210/mend.16.7.089412089353

14. 

J CuiL HuangA ZhaoGuggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pumpJ Biol Chem2781021410220200310.1074/jbc.M20932320012525500

15. 

KR StayrookKS BramlettRS SavkurRegulation of carbohydrate metabolism by the farnesoid X receptorEndocrinology146984991200510.1210/en.2004-096515564327

16. 

N LvMY SongEK KimJW ParkKB KwonBH ParkGuggulsterone, a plant sterol, inhibits NF-κB activation and protects pancreatic beta cells from cytokine toxicityMol Cell Endocrinol28949592008

17. 

YR LeeJH LeeEM NohGuggulsterone blocks IL-1β-mediated inflammatory responses by suppressing NF-κB activation in fibroblast-like synoviocytesLife Sci82120312092008

18. 

JH KooI LeeSK YunHU KimBH ParkJW ParkSaponified evening primrose oil reduces melanogenesis in B16 melanoma cells and reduces UV-induced skin pigmentation in humansLipids45401407201010.1007/s11745-010-3405-420352496

19. 

MS EllerBA GilchrestTanning as part of the eukaryotic SOS responsePigment Cell Res13Suppl 8S94S97200010.1034/j.1600-0749.13.s8.17.x11041364

20. 

JA BeavoNL RogersOB CroffordJG HardmanEW SutherlandEV NewmanEffects of xanthine derivatives on lipolysis and on adenosine 3′,5′-monophosphate phosphodiesterase activityMol Pharmacol65976031970

21. 

K WakamatsuA GrahamD CookAJ ThodyCharacterisation of ACTH peptides in human skin and their activation of the melanocortin-1 receptorPigment Cell Res10288297199710.1111/j.1600-0749.1997.tb00688.x9359624

22. 

T TamagawaH NikiA NikiInsulin release independent of a rise in cytosolic free Ca2+ by forskolin and phorbol esterFEBS Lett183430432198510.1016/0014-5793(85)80825-52985438

23. 

HY ParkV RussakovskyS OhnoBA GilchrestThe beta isoform of protein kinase C stimulates human melanogenesis by activating tyrosinase in pigment cellsJ Biol Chem268117421174919937685020

24. 

M SasakiT HorikoshiH UchiwaY MiyachiUp-regulation of tyrosinase gene by nitric oxide in human melanocytesPigment Cell Res13248252200010.1034/j.1600-0749.2000.130406.x10952392

25. 

DS KimSH ParkSB KwonK LiSW YounKC Park(-)-Epigallocatechin-3-gallate and hinokitiol reduce melanin synthesis via decreased MITF productionArch Pharm Res27334339200410.1007/BF0298006915089040

26. 

JH KooHT KimHY YoonEffect of xanthohumol on melanogenesis in B16 melanoma cellsExp Mol Med40313319200810.3858/emm.2008.40.3.31318587269

27. 

N LvJH KooHY YoonEffect of Angelica gigas extract on melanogenesis in B16 melanoma cellsInt J Mol Med207637672007

28. 

B SharmaR SalunkeS SrivastavaC MajumderP RoyEffects of guggulsterone isolated from Commiphora mukul in high fat diet induced diabetic ratsFood Chem Toxicol4726312639200919635521

29. 

S SarfarazIA SiddiquiDN SyedF AfaqH MukhtarGuggulsterone modulates MAPK and NF-κB pathways and inhibits skin tumorigenesis in SENCAR miceCarcinogenesis2920112018200818684729

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Koo J, Rhee K, Koh H, Jang H, Park B and Park J: Guggulsterone inhibits melanogenesis in B16 murine melanoma cells by downregulating tyrosinase expression. Int J Mol Med 30: 974-978, 2012.
APA
Koo, J., Rhee, K., Koh, H., Jang, H., Park, B., & Park, J. (2012). Guggulsterone inhibits melanogenesis in B16 murine melanoma cells by downregulating tyrosinase expression. International Journal of Molecular Medicine, 30, 974-978. https://doi.org/10.3892/ijmm.2012.1057
MLA
Koo, J., Rhee, K., Koh, H., Jang, H., Park, B., Park, J."Guggulsterone inhibits melanogenesis in B16 murine melanoma cells by downregulating tyrosinase expression". International Journal of Molecular Medicine 30.4 (2012): 974-978.
Chicago
Koo, J., Rhee, K., Koh, H., Jang, H., Park, B., Park, J."Guggulsterone inhibits melanogenesis in B16 murine melanoma cells by downregulating tyrosinase expression". International Journal of Molecular Medicine 30, no. 4 (2012): 974-978. https://doi.org/10.3892/ijmm.2012.1057
Copy and paste a formatted citation
x
Spandidos Publications style
Koo J, Rhee K, Koh H, Jang H, Park B and Park J: Guggulsterone inhibits melanogenesis in B16 murine melanoma cells by downregulating tyrosinase expression. Int J Mol Med 30: 974-978, 2012.
APA
Koo, J., Rhee, K., Koh, H., Jang, H., Park, B., & Park, J. (2012). Guggulsterone inhibits melanogenesis in B16 murine melanoma cells by downregulating tyrosinase expression. International Journal of Molecular Medicine, 30, 974-978. https://doi.org/10.3892/ijmm.2012.1057
MLA
Koo, J., Rhee, K., Koh, H., Jang, H., Park, B., Park, J."Guggulsterone inhibits melanogenesis in B16 murine melanoma cells by downregulating tyrosinase expression". International Journal of Molecular Medicine 30.4 (2012): 974-978.
Chicago
Koo, J., Rhee, K., Koh, H., Jang, H., Park, B., Park, J."Guggulsterone inhibits melanogenesis in B16 murine melanoma cells by downregulating tyrosinase expression". International Journal of Molecular Medicine 30, no. 4 (2012): 974-978. https://doi.org/10.3892/ijmm.2012.1057
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team