GIT1Y321 phosphorylation is required for ERK1/2- and PDGF-dependent VEGF secretion from osteoblasts to promote angiogenesis and bone healing

G AugustinA AntabakS DavilaThe periosteum. Part 1: anatomy, histology and molecular biologyInjury3811151130200717889870

ML BrandiP Collin-OsdobyVascular biology and the skeletonJ Bone Miner Res21183192200610.1359/JBMR.05091716418774

H EckardtM DingM LindRecombinant human vascular endothelial growth factor enhances bone healing in an experimental nonunion modelJ Bone Joint Surg Br8714341438200510.1302/0301-620X.87B10.1622616189323

DE RichardE BerraE Gothiep42/44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor1α (HIF-1) and enhance the transcriptional activity of HIF-1J Biol Chem2743263132637199910551817

G PagesJ MilaniniDE RichardSignaling angiogenesis via p42/p44 MAP kinase cascadeJ Ann NY Acad Sci902187200200010.1111/j.1749-6632.2000.tb06313.x10865838

V WitteB LaffertP GintschelInduction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa BJ Immumol18184258432200810.4049/jimmunol.181.12.842519050260

G YinJ HaendelerC YanGIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factorMol Cell Biol24875885200410.1128/MCB.24.2.875-885.200414701758

J PangR HoefenGS PryhuberG-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular developmentCirculation11915241532200910.1161/CIRCULATIONAHA.108.82399719273721

CE TurnerMC BrownJA PerrottaPaxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: a role in cytoskeletal remodelingJ Cell Biol145851863199910.1083/jcb.145.4.85110330411

G YinC YanBC BerkAng II signaling pathways mediated by tyrosineInt J Biochem Cell Biol35780783200310.1016/S1357-2725(02)00300-X12676164

DJ WebbMW MayhewM KovalenkoIdentifucation of phosphorylation sites in GIT1J Cell Sci11928472850200610.1242/jcs.0304416825424

J WangG YinP MenonPhosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 321 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cellsArterioscler Thromb Vasc Biol3019761982201010.1161/ATVBAHA.110.212415

G YinQ ZhengC YanGIT1 is a scaffold for ERK1/2 activation in focal adhesionsJ Biol Chem2802770527712200510.1074/jbc.M50227120015923189

G TiscorniaO SingerIM VermaProduction and purification of lentiviral vectorsNat Protoc1241245200610.1038/nprot.2006.3717406239

KK FrickDA BushinskyChronic metabolic acidosis reversibly inhibits extracellular matrix gene expression in mouse osteoblastsAm J Physiol Renal Physiol275F840F84719989815143

S SakanoY ZhuL SandellCartilage-derived retinoic acid-sensitive protein and type II collagen expression during fracture healing are potential targets for Sox9 regulationJ Bone Miner Res1418911901199910.1359/jbmr.1999.14.11.189110571689

H MayerH BertramW LindenmaierVascular endothelial growth factor (VEGF-A) expression in human mesenchyreal stem cells: autocrine and paracrine role on osteoblastic and endothelial differentiationJ Cell Biochem95827839200510.1002/jcb.2046215838884

SE AldridgeTW LennardJR WilliamsMA BirchVascular endothelial growth factor receptors in osteoclast diferentiation and functionBiochem Biophys Res Commun335793798200510.1016/j.bbrc.2005.07.14516105658

S NiidaT KondoS HiratsukaVEGF receptor 1 signaling is essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient miceProc Natl Acad Sci USA1021401614021200510.1073/pnas.050354410216172397

MM DeckersRL van BezooijenG van der HorstBone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor AEndocrinology14315451553200210.1210/endo.143.4.8719

K KatoH TokudaS AdachiRole of heat shock protein 27 in transforming growth factor-β stimulated vascular endothelial growth factor release in osteoblastsInt J Mol Med274234282011

D FeldserF AganiNV IyerReciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2Cancer Res5939153918199910463582

S SalcedaI BeckV SrinivasJ CaroComplex role of protein phosphorylation in gene activation by hypoxiaKidney Int51556559199710.1038/ki.1997.789027738

J WuS BrandtSM HuderLingand and cell-specific effects of signal transduction pathway inhibitors on progestin-induced vascular endothelial growth factor levels in human breast cancer cellsMol Endocrinol19312326200510.1210/me.2004-0252

KP HofmannP ScheererPW HildebrandA G protein-coupled receptor at work the rhodopsin modelTrends Biochen Sci341102211027200919836958

A ClaingW ChenWE MillerBeta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosisJ Biol Chen2764250942513200110.1074/jbc.M10839920011533043

J OverbaughAD MillerMV EidenReceptors and entry cofactors for retroviruses include single and multiple transmembrane-spanning proteins as well as newly described glycophosphatidylinositol-anchored and secreted proteinsMicrobiol Mol Biol Rev65371389200110.1128/MMBR.65.3.371-389.2001

J FernandezI YamanWC MerrickRegulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2alpha phosphorylation and translation of a small upstream open reading frameJ Biol Chem27720502058200210.1074/jbc.M109199200

I SeguraCL EssmannS WeingesA Acker-PalmerGrb4 and GIT1 transduce ephrinB reversesignals modulating spine morphogenesis and synapse formationNat Neurosci10301310200710.1038/nn185817310244