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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2012 Volume 30 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Article

Trimetazidine improves right ventricular function by increasing miR-21 expression

  • Authors:
    • Fang Liu
    • Li Yin
    • Lulu Zhang
    • Wenhua Liu
    • Jingjin Liu
    • Yongshun Wang
    • Bo Yu
  • View Affiliations / Copyright

    Affiliations: Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, P.R. China, Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, P.R. China
  • Pages: 849-855
    |
    Published online on: July 25, 2012
       https://doi.org/10.3892/ijmm.2012.1078
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Abstract

Trimetazidine (TMZ) improves left ventricular (LV) function and alleviates angina. TMZ is a metabolism-related drug, but its molecular actions and non-metabolic effects have not yet been elucidated. In this study, we investigated whether TMZ improves right ventricular (RV) function and decreases apoptosis in RV myocardial cells (RVMCs) by regulating miRNA-21 (miR-21) expression in vitro and in vivo. We used cultivated RVMCs and LV myocardial cells (LVMCs) and provided hypoxic stimulation for 24 h to induce MC apoptosis. RVMCs showed more severe apoptosis as indicated by terminal deoxynucleotidyl-transferase-mediated dUTP nick end-labeling (TUNEL) staining and caspase-3 protein and activity assays. The decrease in miR-21 expression was more dramatic in RVMCs. Subsequently, TMZ (10 µM) was added to the RVMCs prior to hypoxic stimulation. The TMZ-treated RVMCs showed less apoptosis and an increased expression of miR-21. The transfection of RVMCs with a miR‑21-specific inhibitor weakened the protective effects of TMZ. To evaluate TMZ effectiveness in right heart failure, we used a combination treatment of hypoxia and the vascular endothelial growth factor receptor blocker, Su5416, to construct a stable model, and administered TMZ. TMZ improved RV function (as indicated by an increase in tricuspid annular plane systolic excursion), and inhibited fibrosis. TMZ also protects RVMCs againts apoptosis and increases miR-21 expression.
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1. 

MP VerziDJ McCulleyS De ValThe right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart fieldDev Biol287134145200510.1016/j.ydbio.2005.08.041

2. 

S ZaffranRG KellySM MeilhacRight ventricular myocardium derives from the anterior heart fieldCirc Res95261268200410.1161/01.RES.0000136815.73623.BE15217909

3. 

F HaddadSA HuntDN RosenthalDJ MurphyRight ventricular function in cardiovascular disease, part I: Anatomy, physiology, aging, and functional assessment of the right ventricleCirculation11714361448200810.1161/CIRCULATIONAHA.107.65357618347220

4. 

F HaddadR DoyleDJ MurphySA HuntRight ventricular function in cardiovascular disease, part II: pathophysiology, clinical importance, and management of right ventricular failureCirculation11717171731200810.1161/CIRCULATIONAHA.107.65358418378625

5. 

M StrniskovaT RavingerovaJ NeckarChanges in the expression and/or activation of regulatory proteins in rat hearts adapted to chronic hypoxiaGen Physiol Biophys252541200616714773

6. 

GY WangDT McCloskeyS TurcatoContrasting inotropic responses to alpha1-adrenergic receptor stimulation in left versus right ventricular myocardiumAm J Physiol Heart Circ Physiol291H2013H2017200610.1152/ajpheart.00167.200616731650

7. 

SC ManchandaS KrishnaswamiCombination treatment with trimetazidine and diltiazem in stable angina pectorisHeart78353357199710.1136/hrt.78.4.3539404250

8. 

H SzwedZ SadowskiW ElikowskiCombination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study (TRIMPOL II). Trimetazidine in POLandEur Heart J2222672274200110.1053/euhj.2001.2896

9. 

G KoberT BuckH SievertC VallbrachtMyocardial protection during percutaneous transluminal coronary angioplasty: effects of trimetazidineEur Heart J13110911151992

10. 

X LiuY GaiF LiuTrimetazidine inhibits pressure overload-induced cardiac fibrosis through NADPH oxidase-ROS-CTGF pathwayCardiovasc Res88150158201010.1093/cvr/cvq18120534773

11. 

JN WeissP KorgeHM HondaP PingRole of the mitochondrial permeability transition in myocardial diseaseCirc Res93292301200310.1161/01.RES.0000087542.26971.D412933700

12. 

AP HalestrapSJ ClarkeSA JavadovMitochondrial permeability transition pore opening during myocardial reperfusion - a target for cardioprotectionCardiovasc Res61372385200410.1016/S0008-6363(03)00533-914962470

13. 

LP LimNC LauP Garrett-EngeleMicroarray analysis shows that some microRNAs downregulate large numbers of target mRNAsNature433769773200510.1038/nature0331515685193

14. 

EM SmallRJ FrostEN OlsonMicroRNAs add a new dimension to cardiovascular diseaseCirculation12110221032201010.1161/CIRCULATIONAHA.109.88904820194875

15. 

Y ChengC ZhangMicroRNA-21 in cardiovascular diseaseJ Cardiovasc Transl Res3251255201010.1007/s12265-010-9169-720560046

16. 

PA da Costa MartinsLJ De WindtMiR-21: A miRaculous Socratic paradoxCardiovasc Res87397400201020562424

17. 

B OzpolatU AkarM SteinerProgrammed cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cellsMol Cancer Res595108200710.1158/1541-7786.MCR-06-0125

18. 

H AllgayerPdcd4, a colon cancer prognostic that is regulated by a microRNACrit Rev Oncol Hematol73185191201010.1016/j.critrevonc.2009.09.00119836969

19. 

HJ BogaardR NatarajanSC HendersonChronic pulmonary artery pressure elevation is insufficient to explain right heart failureCirculation12019511960200910.1161/CIRCULATIONAHA.109.88384319884466

20. 

J KajsturaE CigolaA MalhotraAngiotensin II induces apoptosis of adult ventricular myocytes in vitroJ Mol Cell Cardiol29859870199710.1006/jmcc.1996.03339152847

21. 

F CacciapuotiEchocardiographic evaluation of right heart function and pulmonary vascular bedInt J Cardiovasc Imaging25689697200910.1007/s10554-009-9478-619634000

22. 

C VitaleM WajngatenB SposatoTrimetazidine improves left ventricular function and quality of life in elderly patients with coronary artery diseaseEur Heart J2518141821200410.1016/j.ehj.2004.06.03415474696

23. 

P Di NapoliAA TaccardiA BarsottiLong term cardio-protective action of trimetazidine and potential effect on the inflammatory process in patients with ischaemic dilated cardiomyopathyHeart91161165200515657223

24. 

PF KantorA LucienR KozakGD LopaschukThe antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolaseCirc Res86580588200010.1161/01.RES.86.5.580

25. 

G FragassoA PalloshiP PuccettiA randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failureJ Am Coll Cardiol48992998200610.1016/j.jacc.2006.03.06016949492

26. 

H TuunanenE EngblomA NaumTrimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathyCirculation11812501258200810.1161/CIRCULATIONAHA.108.77801918765391

27. 

M TatsuguchiHY SeokTE CallisExpression of microRNAs is dynamically regulated during cardiomyocyte hypertrophyJ Mol Cell Cardiol4211371141200710.1016/j.yjmcc.2007.04.00417498736

28. 

D SayedM HeC HongMicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligandJ Biol Chem2852028120290201010.1074/jbc.M110.10920720404348

29. 

Y ChengX LiuS ZhangMicroRNA-21 protects against the H(2)O(2)-induced injury on cardiac myocytes via its target gene PDCD4J Mol Cell Cardiol475142009

30. 

S DongY ChengJ YangMicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarctionJ Biol Chem2842951429525200910.1074/jbc.M109.02789619706597

31. 

J QianX RenX WangBlockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell deathCirc Res10512231231200910.1161/CIRCRESAHA.109.20037819850943

32. 

P MeyerRV DesaiM MujibRight ventricular ejection fraction <20% is an independent predictor of mortality but not of hospitalization in older systolic heart failure patientsInt J Cardiol1551201252012

33. 

NF VoelkelRA QuaifeLA LeinwandRight ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failureCirculation11418831891200610.1161/CIRCULATIONAHA.106.632208

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Copy and paste a formatted citation
Spandidos Publications style
Liu F, Yin L, Zhang L, Liu W, Liu J, Wang Y and Yu B: Trimetazidine improves right ventricular function by increasing miR-21 expression. Int J Mol Med 30: 849-855, 2012.
APA
Liu, F., Yin, L., Zhang, L., Liu, W., Liu, J., Wang, Y., & Yu, B. (2012). Trimetazidine improves right ventricular function by increasing miR-21 expression. International Journal of Molecular Medicine, 30, 849-855. https://doi.org/10.3892/ijmm.2012.1078
MLA
Liu, F., Yin, L., Zhang, L., Liu, W., Liu, J., Wang, Y., Yu, B."Trimetazidine improves right ventricular function by increasing miR-21 expression". International Journal of Molecular Medicine 30.4 (2012): 849-855.
Chicago
Liu, F., Yin, L., Zhang, L., Liu, W., Liu, J., Wang, Y., Yu, B."Trimetazidine improves right ventricular function by increasing miR-21 expression". International Journal of Molecular Medicine 30, no. 4 (2012): 849-855. https://doi.org/10.3892/ijmm.2012.1078
Copy and paste a formatted citation
x
Spandidos Publications style
Liu F, Yin L, Zhang L, Liu W, Liu J, Wang Y and Yu B: Trimetazidine improves right ventricular function by increasing miR-21 expression. Int J Mol Med 30: 849-855, 2012.
APA
Liu, F., Yin, L., Zhang, L., Liu, W., Liu, J., Wang, Y., & Yu, B. (2012). Trimetazidine improves right ventricular function by increasing miR-21 expression. International Journal of Molecular Medicine, 30, 849-855. https://doi.org/10.3892/ijmm.2012.1078
MLA
Liu, F., Yin, L., Zhang, L., Liu, W., Liu, J., Wang, Y., Yu, B."Trimetazidine improves right ventricular function by increasing miR-21 expression". International Journal of Molecular Medicine 30.4 (2012): 849-855.
Chicago
Liu, F., Yin, L., Zhang, L., Liu, W., Liu, J., Wang, Y., Yu, B."Trimetazidine improves right ventricular function by increasing miR-21 expression". International Journal of Molecular Medicine 30, no. 4 (2012): 849-855. https://doi.org/10.3892/ijmm.2012.1078
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