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Article

Red Liriope platyphylla contains a large amount of polyphenolic compounds which stimulate insulin secretion and suppress fatty liver formation through the regulation of fatty acid oxidation in OLETF rats

  • Authors:
    • Hye Ryun Lee
    • Ji Eun Kim
    • Jun Seo Goo
    • Sun Il Choi
    • In Sik Hwang
    • Young Ju Lee
    • Hong Joo Son
    • Hee Seob Lee
    • Jong Sup Lee
    • Dae Youn Hwang
  • View Affiliations / Copyright

    Affiliations: College of Natural Resources and Life Science, Pusan National University, Gyeongsangnam-do 627-706, Republic of Korea, College of Human Ecology, Pusan National University, Busan 609-735, Republic of Korea, Nonghyup Sandong Processing Plant, Miryang 627-706, Republic of Korea
  • Pages: 905-913
    |
    Published online on: July 27, 2012
       https://doi.org/10.3892/ijmm.2012.1081
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Abstract

Red Liriope platyphylla (RLP) manufactured by two repeated steps (steaming and drying) stimulates the insulin secretion ability and glucose receptor signaling pathway in an animal model for type I diabetes. This study examined the levels of glucose and lipid metabolism-related factors in a useful animal model for type II diabetes with obesity following RLP treatment for 3 weeks to determine if RLP treatment affects the glucose concentration, insulin secretion and fatty acid oxidation. The following results were obtained: i) RLP contained a large amount of polyphenolic compounds; ii) insulin secretion was induced in RLP-treated OLETF rats, although there were no significant differences in body weight, glucose tolerance test and glucose concentration; iii) the RLP-treated OLETF rats showed a significant increase in adiponectin concentration but the concentration of triglyceride and LDL decreased compared to the vehicle-treated rats; iv) although the abdominal fat mass and adipocyte size did not change with RLP treatment, expression of the adipocyte marker genes and β-oxidation genes in fat tissue was recovered to the level of the LETO rats; v) fatty liver formation was reduced dramatically in the liver of the RLP-treated group compared to the vehicle-treated group; vi) the expression of adipocyte marker genes and the β-oxidation gene in the liver tissue were generally similar to those of the abdominal fat but PPAR-γ showed a reverse pattern in the RLP- and vehicle-treated OLETF rats. These results suggest that RLP may stimulate insulin secretion and a decrease in lipid in serum, and may also suppress fatty liver formation through the regulation of fatty acid oxidation. The data presented here highlight the possibility that RLP can be considered a candidate for the prevention or alleviation of obesity-related diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Lee HR, Kim JE, Goo JS, Choi SI, Hwang IS, Lee YJ, Son HJ, Lee HS, Lee JS, Hwang DY, Hwang DY, et al: Red Liriope platyphylla contains a large amount of polyphenolic compounds which stimulate insulin secretion and suppress fatty liver formation through the regulation of fatty acid oxidation in OLETF rats. Int J Mol Med 30: 905-913, 2012.
APA
Lee, H.R., Kim, J.E., Goo, J.S., Choi, S.I., Hwang, I.S., Lee, Y.J. ... Hwang , D.Y. (2012). Red Liriope platyphylla contains a large amount of polyphenolic compounds which stimulate insulin secretion and suppress fatty liver formation through the regulation of fatty acid oxidation in OLETF rats. International Journal of Molecular Medicine, 30, 905-913. https://doi.org/10.3892/ijmm.2012.1081
MLA
Lee, H. R., Kim, J. E., Goo, J. S., Choi, S. I., Hwang, I. S., Lee, Y. J., Son, H. J., Lee, H. S., Lee, J. S., Hwang , D. Y."Red Liriope platyphylla contains a large amount of polyphenolic compounds which stimulate insulin secretion and suppress fatty liver formation through the regulation of fatty acid oxidation in OLETF rats". International Journal of Molecular Medicine 30.4 (2012): 905-913.
Chicago
Lee, H. R., Kim, J. E., Goo, J. S., Choi, S. I., Hwang, I. S., Lee, Y. J., Son, H. J., Lee, H. S., Lee, J. S., Hwang , D. Y."Red Liriope platyphylla contains a large amount of polyphenolic compounds which stimulate insulin secretion and suppress fatty liver formation through the regulation of fatty acid oxidation in OLETF rats". International Journal of Molecular Medicine 30, no. 4 (2012): 905-913. https://doi.org/10.3892/ijmm.2012.1081
Copy and paste a formatted citation
x
Spandidos Publications style
Lee HR, Kim JE, Goo JS, Choi SI, Hwang IS, Lee YJ, Son HJ, Lee HS, Lee JS, Hwang DY, Hwang DY, et al: Red Liriope platyphylla contains a large amount of polyphenolic compounds which stimulate insulin secretion and suppress fatty liver formation through the regulation of fatty acid oxidation in OLETF rats. Int J Mol Med 30: 905-913, 2012.
APA
Lee, H.R., Kim, J.E., Goo, J.S., Choi, S.I., Hwang, I.S., Lee, Y.J. ... Hwang , D.Y. (2012). Red Liriope platyphylla contains a large amount of polyphenolic compounds which stimulate insulin secretion and suppress fatty liver formation through the regulation of fatty acid oxidation in OLETF rats. International Journal of Molecular Medicine, 30, 905-913. https://doi.org/10.3892/ijmm.2012.1081
MLA
Lee, H. R., Kim, J. E., Goo, J. S., Choi, S. I., Hwang, I. S., Lee, Y. J., Son, H. J., Lee, H. S., Lee, J. S., Hwang , D. Y."Red Liriope platyphylla contains a large amount of polyphenolic compounds which stimulate insulin secretion and suppress fatty liver formation through the regulation of fatty acid oxidation in OLETF rats". International Journal of Molecular Medicine 30.4 (2012): 905-913.
Chicago
Lee, H. R., Kim, J. E., Goo, J. S., Choi, S. I., Hwang, I. S., Lee, Y. J., Son, H. J., Lee, H. S., Lee, J. S., Hwang , D. Y."Red Liriope platyphylla contains a large amount of polyphenolic compounds which stimulate insulin secretion and suppress fatty liver formation through the regulation of fatty acid oxidation in OLETF rats". International Journal of Molecular Medicine 30, no. 4 (2012): 905-913. https://doi.org/10.3892/ijmm.2012.1081
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