Red Liriope platyphylla contains a large amount of polyphenolic compounds which stimulate insulin secretion and suppress fatty liver formation through the regulation of fatty acid oxidation in OLETF rats

Lee,Hye  Ryun; Kim,Ji  Eun; Goo,Jun  Seo; Choi,Sun  Il; Hwang,In  Sik; Lee,Young  Ju; Son,Hong  Joo; Lee,Hee  Seob; Lee,Jong  Sup; Hwang
,Dae  Youn

doi:10.3892/ijmm.2012.1081

Red Liriope platyphylla contains a large amount of polyphenolic compounds which stimulate insulin secretion and suppress fatty liver formation through the regulation of fatty acid oxidation in OLETF rats

Authors:
- Hye Ryun Lee
- Ji Eun Kim
- Jun Seo Goo
- Sun Il Choi
- In Sik Hwang
- Young Ju Lee
- Hong Joo Son
- Hee Seob Lee
- Jong Sup Lee
- Dae Youn Hwang
View Affiliations

Affiliations: College of Natural Resources and Life Science, Pusan National University, Gyeongsangnam-do 627-706, Republic of Korea, College of Human Ecology, Pusan National University, Busan 609-735, Republic of Korea, Nonghyup Sandong Processing Plant, Miryang 627-706, Republic of Korea
Published online on: July 27, 2012 https://doi.org/10.3892/ijmm.2012.1081
Pages: 905-913

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Red Liriope platyphylla (RLP) manufactured by two repeated steps (steaming and drying) stimulates the insulin secretion ability and glucose receptor signaling pathway in an animal model for type I diabetes. This study examined the levels of glucose and lipid metabolism-related factors in a useful animal model for type II diabetes with obesity following RLP treatment for 3 weeks to determine if RLP treatment affects the glucose concentration, insulin secretion and fatty acid oxidation. The following results were obtained: i) RLP contained a large amount of polyphenolic compounds; ii) insulin secretion was induced in RLP-treated OLETF rats, although there were no significant differences in body weight, glucose tolerance test and glucose concentration; iii) the RLP-treated OLETF rats showed a significant increase in adiponectin concentration but the concentration of triglyceride and LDL decreased compared to the vehicle-treated rats; iv) although the abdominal fat mass and adipocyte size did not change with RLP treatment, expression of the adipocyte marker genes and β-oxidation genes in fat tissue was recovered to the level of the LETO rats; v) fatty liver formation was reduced dramatically in the liver of the RLP-treated group compared to the vehicle-treated group; vi) the expression of adipocyte marker genes and the β-oxidation gene in the liver tissue were generally similar to those of the abdominal fat but PPAR-γ showed a reverse pattern in the RLP- and vehicle-treated OLETF rats. These results suggest that RLP may stimulate insulin secretion and a decrease in lipid in serum, and may also suppress fatty liver formation through the regulation of fatty acid oxidation. The data presented here highlight the possibility that RLP can be considered a candidate for the prevention or alleviation of obesity-related diseases.

View Figures

View References

1.	MK HuhHW HuhJS ChoiBK LeeGenetic diversity and population structure of Liriope platyphylla (Liliaceae) in KoreaJ Life Sci17328333200710.5352/JLS.2007.17.3.328
2.	YC LeeJC LeeYB SeoYB KookLiriopis tuber inhibits OVA-induced airway inflammation and bronchial hyperresponsiveness in murine model of asthmaJ Ethnopharmacol101144152200510.1016/j.jep.2005.04.030
3.	SB ChoiJD WhaS ParkThe insulin sensitizing effect of homoisoflavone-enriched fraction in Liriope platyphylla Wang et Tang via PI3-kinase pathwayLife Sci7526532664200410.1016/j.lfs.2004.04.03915369701
4.	SW KimIM ChangKB OhInhibition of the bacterial surface protein anchoring transpeptidase sortase by medicinal plantsBiosci Biotechnol Biochem6627512754200210.1271/bbb.66.275112596883
5.	J HurP LeeJ KimAJ KimH KimSY KimInduction of nerve growth factor by a butanol fraction of Liriope platyphylla in C6 and primary astrocyte cellsBiol Pharm Bull2712571260200410.1248/bpb.27.1257
6.	S JeongK ChaeYS JungYH RhoJ LeeJ HaKH YoonGC KimKS OhSS ShinM YoonThe Korean traditional medicine Gyeongshingangjeehwan inhibits obesity through the regulation of leptin and PPARalpha action in OLETF ratsJ Ethnopharmacol119245251200810.1016/j.jep.2008.06.037
7.	J HurP LeeE MoonI KangSH KimMS OhSY KimNeurite outgrowth induced by spicatoside A, a steroidal saponin, via the tyrosine kinase A receptor pathwayEur J Pharmacol620915200910.1016/j.ejphar.2009.08.01619695245
8.	YK LeeJE KimSH NamJS GooSI ChoiYH ChoiCJ BaeJM WooJS ChoDY HwangDifferential regulation of the biosynthesis of glucose transporters by the PI3-K and MAPK pathways of insulin signaling by treatment with novel compounds from Liriope platyphyllaInt J Mol Med27319327201121165549
9.	JE KimSH NamSI ChoiIS HwangHR LeeMJ JangCY LeeHJ SoonHS LeeHS KimAqueous extracts of Liriope platyphylla are tightly-regulated by insulin secretion from pancreatic islets and by increased glucose uptake through glucose transporters expressed in liver hepatocytesBiomol Ther193483562011
10.	K KimHY KimKorean red ginseng stimulates insulin release from isolated rat pancreatic isletsJ Ethnopharmacol120190195200810.1016/j.jep.2008.08.00618773949
11.	JM LuQ YaoC ChenGinseng compounds: an update on their molecular mechanisms and medical applicationsCurr Vasc Pharmacol7293302200910.2174/15701610978834076719601854
12.	TB NgPharmacological activity of sanchi ginseng (Panax notoginseng)J Pharm Pharmacol5810071019200610.1211/jpp.58.8.000116872547
13.	D KieferT PantusoPanax ginsengAm Fam Physician6815391542200314596440
14.	NI BaekDS KimYH LeeJD ParkCB LeeSI KimGinsenoside Rh4, a genuine dammarane glycoside from Korean red ginsengPlanta Med628687199610.1055/s-2006-9578168720394
15.	TK YunYS LeeKH KwonKJ ChoiSaponin contents and anticarcinogenic effects of ginseng depending on types and ages in miceActa Pharmacol Sin1729329819969812705
16.	SI ChoiHR LeeJS GooJE KimSH NamIS HwangYJ LeeSH PrakHS LeeJS LeeEffects of steaming time and frequency for manufactured red Liriope platyphylla on the insulin secretion ability and insulin receptor signaling pathwayLab Anim Res27117126201110.5625/lar.2011.27.2.11721826171
17.	SD KimYS KuIZ LeeID KimKS YounGerneral components and sensory evaluation of hot water extract from Liriopis TuberJ Korean Soc Food Sci Nutr3020242001
18.	JE KimYK LeeSH NamSI ChoiJS GooMJ JangHS LeeHJ SonCY LeeDY HwangThe symptoms of atopic dermatitis in NC/Nga mice were significantly relieved by the water extract of Liriope platyphyllaLab Anim Res26377384201010.5625/lar.2010.26.4.377
19.	SS ShinYS JungKH YoonS ChoiY HongD ParkH LeeBI SeoHY LeeM YoonThe Korean traditional medicine gyeongshingangjeehwan inhibits adipocyte hypertrophy and visceral adipose tissue accumulation by activating PPARalpha actions in rat white adipose tissuesJ Ethnopharmacol1274754201010.1016/j.jep.2009.09.052
20.	Y AritaS KiharaN OuchiM TakahashiK MaedaJ MiyagawaK HottaI ShimomuraT NakamuraK MiyaokaParadoxical decrease of an adipose-specific protein, adiponectin, in obesityBiochem Biophys Res Commun2577983199910.1006/bbrc.1999.025510092513
21.	WS YangWJ LeeT FunahashiS TanakaY MatsuzawaCL ChaoCL ChenTY TaiLM ChuangWeight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectinJ Clin Endocrinol Metab8638153819200110.1210/jcem.86.8.774111502817
22.	JJ DiezP IglesiasThe role of the novel adipocyte-derived hormone adiponectin in human diseaseEur J Endocrinol148293300200310.1530/eje.0.148029312611609
23.	S RoySK DontamallaAK MondruS SannigrahiPR VeerareddyDownregulation of apoptosis and modulation of TGF-β1 by sodium selenate prevents streptozotocin-induced diabetic rat renal impairmentBiol Trace Elem Res13955712011
24.	JJ KimM WangR PaschkeCrystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrateProc Natl Acad Sci USA9075237527199310.1073/pnas.90.16.75238356049
25.	K KawanoT HirashimaS MoriT NatoriOLETF (Otsuka Long-Evans Tokushima Fatty) rat: a new NIDDM rat strainDiabetes Res Clin Pract24S317S320199410.1016/0168-8227(94)90269-07859627
26.	TH MoranUnraveling the obesity of OLETF ratsPhysiol Behav947178200810.1016/j.physbeh.2007.11.03518190934
27.	Y MoriY IkedaSimilarity and dissimilarity between the OLETF rats and obese subjects with NIDDMObesity and NIDMM. Lessons from the OLETF RatK ShimaElsevier Science BVAmsterdam2372441999
28.	D Le RoithY ZickRecent advances in our understanding of insulin action and insulin resistanceDiabetes Care24588597200111289486
29.	C TahaA KlipThe insulin signaling pathwayJ Membr Biol169112199910.1007/PL00005896
30.	O UkkolaM SantaniemiAdiponectin: a link between excess adiposity and associated comorbidities?J Mol Med80696702200210.1007/s00109-002-0378-712436346
31.	A CoppolaR MarfellaL CoppolaE TagliamonteD FontanaE LiguoriT CirilloM CafieroS NataleC AstaritaEffect of weight loss on coronary circulation and adiponectin levels in obese womenInt J Cardiol134414416200910.1016/j.ijcard.2007.12.08718378021
32.	H JiMI FriedmanReduced capacity for fatty acid oxidation in rats with inherited susceptibility to diet-induced obesityMetabolism5611241130200710.1016/j.metabol.2007.04.00617618960
33.	T MuraseM AokiI TokimitsuSupplementation with alpha-linolenic acid-rich diacylglycerol suppresses fatty liver formation accompanied by an up-regulation of beta-oxidation in Zucker fatty ratsBiochim Biophys Acta1733224231200510.1016/j.bbalip.2004.12.01515863369