Solid lipid nanoparticles of paclitaxel strengthened by hydroxypropyl-β-cyclodextrin as an oral delivery system

  • Authors:
    • Jong-Suep Baek
    • Jae-Woo So
    • Sang-Chul Shin
    • Cheong-Weon Cho
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  • Published online on: August 3, 2012     https://doi.org/10.3892/ijmm.2012.1086
  • Pages: 953-959
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Abstract

The objective of this study was to evaluate the potential of surface-modified paclitaxel (PTX)-incorporated solid lipid nanoparticles with hydroxypropyl-β-cyclodextrin (smPSH). The smPSH released 89.70±3.99% of its entrapped PTX within 24 h when placed in dissolution medium containing sodium lauryl sulfate. The cellular uptake of PTX from smPSH in Caco-2 cells was 5.3-fold increased compared to a PTX solution based on a Taxol formulation. Moreover, smPSH showed an increased cytotoxicity compared to PTX solution. In addition, AUC (5.43 µg•h/ml) and Cmax (1.44 µg/ml) of smPSH were higher than those (1.81 µg•h/ml and 0.73 µg/ml) of PTX solution. The drug concentration of smPSH (11.12±4.45 ng/mg of lymph tissue) in lymph nodes was higher than that of the PTX solution (0.89±0.75 ng/mg of lymph tissue), suggesting that more PTX was transported to the lymphatic vessels in the form of smPSH. In conclusion, smPSH have a potential as an alternative delivery system for oral administration of PTX.
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October 2012
Volume 30 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Baek J, So J, Shin S and Cho C: Solid lipid nanoparticles of paclitaxel strengthened by hydroxypropyl-β-cyclodextrin as an oral delivery system. Int J Mol Med 30: 953-959, 2012
APA
Baek, J., So, J., Shin, S., & Cho, C. (2012). Solid lipid nanoparticles of paclitaxel strengthened by hydroxypropyl-β-cyclodextrin as an oral delivery system. International Journal of Molecular Medicine, 30, 953-959. https://doi.org/10.3892/ijmm.2012.1086
MLA
Baek, J., So, J., Shin, S., Cho, C."Solid lipid nanoparticles of paclitaxel strengthened by hydroxypropyl-β-cyclodextrin as an oral delivery system". International Journal of Molecular Medicine 30.4 (2012): 953-959.
Chicago
Baek, J., So, J., Shin, S., Cho, C."Solid lipid nanoparticles of paclitaxel strengthened by hydroxypropyl-β-cyclodextrin as an oral delivery system". International Journal of Molecular Medicine 30, no. 4 (2012): 953-959. https://doi.org/10.3892/ijmm.2012.1086