Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
November 2012 Volume 30 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November 2012 Volume 30 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT

  • Authors:
    • Ming-Ho Chen
    • Ming-Yang Lee
    • Jing-Jing Chuang
    • Yi-Zhen Li
    • Sin-Tzu Ning
    • Jung-Chou Chen
    • Yi-Wen Liu
  • View Affiliations / Copyright

    Affiliations: Department of Chinese Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan, R.O.C., Department of Hematology and Oncology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan, R.O.C., Department of Microbiology, Immunology and Biopharmaceuticals, National Chiayi University, Chiayi, Taiwan, R.O.C., School of Post Baccalaureate Chinese Medicine, Chinese Medical University, Taichung, Taiwan, R.O.C.
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1021-1028
    |
    Published online on: August 20, 2012
       https://doi.org/10.3892/ijmm.2012.1096
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Although hepatitis C virus (HCV) affects approximately 130-170 million people worldwide, no vaccines are available. HCV is an important cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma, leading to the need for liver transplantation. In this study, curcumin, a constituent used in traditional Chinese medicine, has been evaluated for its anti-HCV activity and mechanism, using a human hepatoma cell line containing the HCV genotype 1b subgenomic replicon. Below the concentration of 20% cytotoxicity, curcumin dose-dependently inhibited HCV replication by luciferase reporter gene assay, HCV RNA detection and HCV protein analysis. Under the same conditions, curcumin also dose-dependently induced heme oxygenase-1 with the highest induction at 24 h. Hemin, a heme oxygenase-1 inducer, also inhibited HCV protein expression in a dose-dependent manner. The knockdown of heme oxygenase-1 partially reversed the curcumin-inhibited HCV protein expression. In addition to the heme oxygenase-1 induction, signaling molecule activities of AKT, extracellular signal-regulated kinases (ERK) and nuclear factor-κB (NF-κB) were inhibited by curcumin. Using specific inhibitors of PI3K-AKT, MEK-ERK and NF-κB, the results suggested that only PI3K-AKT inhibition is positively involved in curcumin-inhibited HCV replication. Inhibition of ERK and NF-κB was likely to promote HCV protein expression. In summary, curcumin inhibited HCV replication by heme oxygenase-1 induction and AKT pathway inhibition. Although curcumin also inhibits ERK and NF-κB activities, it slightly increased the HCV protein expression. This result may provide information when curcumin is used as an adjuvant in anti-HCV therapy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1. 

D LavanchyThe global burden of hepatitis CLiver Int29Suppl 1S74S81200910.1111/j.1478-3231.2008.01934.x

2. 

N BostanT MahmoodAn overview about hepatitis C: a devastating virusCrit Rev Microbiol3691133201010.3109/1040841090335745520345213

3. 

D MoradpourF PeninCM RiceReplication of hepatitis C virusNat Rev Microbiol5453463200710.1038/nrmicro1645

4. 

JJ FeldJH HoofnagleMechanism of action of interferon and ribavirin in treatment of hepatitis CNature436967972200510.1038/nature0408216107837

5. 

S MunirS SaleemM IdreesHepatitis C treatment: current and future perspectivesVirol J7296201010.1186/1743-422X-7-29621040548

6. 

BD LindenbachCM RiceUnravelling hepatitis C virus replication from genome to functionNature436933938200510.1038/nature0407716107832

7. 

CM LeeCH HungSN LuViral etiology of hepatocellular carcinoma and HCV genotypes in TaiwanIntervirology497681200610.1159/00008726716166793

8. 

H HatcherR PlanalpJ ChoFM TortiSV TortiCurcumin: from ancient medicine to current clinical trialsCell Mol Life Sci6516311652200810.1007/s00018-008-7452-418324353

9. 

A GoelAB KunnumakkaraBB AggarwalCurcumin as ‘Curecumin’: from kitchen to clinicBiochem Pharmacol757878092008

10. 

CJ LiLJ ZhangBJ DezubeCS CrumpackerAB PardeeThree inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replicationProc Natl Acad Sci USA9018391842199310.1073/pnas.90.5.18398446597

11. 

A MazumderK RaghavanJ WeinsteinKW KohnY PommierInhibition of human immunodeficiency virus type-1 integrase by curcuminBiochem Pharmacol4911651170199510.1016/0006-2952(95)98514-A7748198

12. 

X SiY WangJ WongJ ZhangBM McManusH LuoDysregulation of the ubiquitin-proteasome system by curcumin suppresses coxsackievirus B3 replicationJ Virol8131423150200710.1128/JVI.02028-0617229707

13. 

MM RechtmanO Har-NoyI Bar-YishayCurcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1alphaFEBS Lett58424852490201010.1016/j.febslet.2010.04.06720434445

14. 

K KimKH KimHY KimHK ChoN SakamotoJ CheongCurcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathwayFEBS Lett584707712201010.1016/j.febslet.2009.12.01920026048

15. 

LE OtterbeinMP SoaresK YamashitaFH BachHeme oxygenase-1: unleashing the protective properties of hemeTrends Immunol24449455200310.1016/S1471-4906(03)00181-912909459

16. 

TO KhorMT HuangKH KwonJY ChanBS ReddyAN KongNrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitisCancer Res661158011584200610.1158/0008-5472.CAN-06-356217178849

17. 

R MotterliniR ForestiR BassiCJ GreenCurcumin, anti-oxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stressFree Radic Biol Med2813031312200010.1016/S0891-5849(00)00294-X10889462

18. 

J GaedekeNA NobleWA BorderCurcumin blocks fibrosis in anti-Thy 1 glomerulonephritis through up-regulation of heme oxygenase 1Kidney Int6820422049200510.1111/j.1523-1755.2005.00658.x16221204

19. 

SJ McNallyEM HarrisonJA RossOJ GardenSJ WigmoreCurcumin induces heme oxygenase-1 in hepatocytes and is protective in simulated cold preservation and warm reperfusion injuryTransplantation81623626200610.1097/01.tp.0000184635.62570.1316495813

20. 

W BaoK LiS RongCurcumin alleviates ethanol-induced hepatocytes oxidative damage involving heme oxygenase-1 inductionJ Ethnopharmacol128549553201010.1016/j.jep.2010.01.02920080166

21. 

EO FarombiS ShrotriyaHK NaSH KimYJ SurhCurcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1Food Chem Toxicol4612791287200810.1016/j.fct.2007.09.09518006204

22. 

KM KimHO PaeM ZhungInvolvement of anti-inflammatory heme oxygenase-1 in the inhibitory effect of curcumin on the expression of pro-inflammatory inducible nitric oxide synthase in RAW264.7 macrophagesBiomed Pharmacother62630636200810.1016/j.biopha.2008.01.00818325727

23. 

HY HsuLC ChuKF HuaLK ChaoHeme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytesJ Cell Physiol215603612200810.1002/jcp.2120618357586

24. 

K DevadasS DhawanHemin activation ameliorates HIV-1 infection via heme oxygenase-1 inductionJ Immunol17642524257200610.4049/jimmunol.176.7.425216547262

25. 

U ProtzerS SeyfriedM QuasdorffAntiviral activity and hepatoprotection by heme oxygenase-1 in hepatitis B virus infectionGastroenterology13311561165200710.1053/j.gastro.2007.07.02117919491

26. 

E LehmannWH El-TantawyM OckerThe heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon responseHepatology51398404201010.1002/hep.2333920044809

27. 

Y ShanJ ZhengRW LambrechtHL BonkovskyReciprocal effects of micro-RNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytesGastroenterology13311661174200710.1053/j.gastro.2007.08.00217919492

28. 

Z ZhuAT WilsonMM MathahsHeme oxygenase-1 suppresses hepatitis C virus replication and increases resistance of hepatocytes to oxidant injuryHepatology4814301439200810.1002/hep.2249118972446

29. 

V TergaonkarNFkappaB pathway: a good signaling paradigm and therapeutic targetInt J Biochem Cell Biol3816471653200610.1016/j.biocel.2006.03.02316766221

30. 

S LuqmanJM PezzutoNFkappaB: a promising target for natural products in cancer chemopreventionPhytother Res24949963201020577970

31. 

Y ZhongT LiuZ GuoCurcumin inhibits ox-LDL-induced MCP-1 expression by suppressing the p38MAPK and NF-kappaB pathways in rat vascular smooth muscle cellsInflamm Res616167201210.1007/s00011-011-0389-322005927

32. 

C JobinCA BradhamMP RussoCurcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activityJ Immunol16334743483199910477620

33. 

AC BhartiN DonatoS SinghBB AggarwalCurcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosisBlood10110531062200310.1182/blood-2002-05-1320

34. 

GL JohnsonR LapadatMitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinasesScience29819111912200210.1126/science.107268212471242

35. 

A ChenS ZhengCurcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signallingBr J Pharmacol153557567200810.1038/sj.bjp.070754217965732

36. 

JH LimTK KwonCurcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activityFood Chem Toxicol484752201010.1016/j.fct.2009.09.01319766691

37. 

A ShehzadF WahidYS LeeCurcumin in cancer chemo-prevention: molecular targets, pharmacokinetics, bioavailability, and clinical trialsArch Pharm343489499201010.1002/ardp.20090031920726007

38. 

MP SoaresFH BachHeme oxygenase-1: from biology to therapeutic potentialTrends Mol Med155058200910.1016/j.molmed.2008.12.00419162549

39. 

Z ZhuAT WilsonBA LuxonBiliverdin inhibits hepatitis C virus nonstructural 3/4A protease activity: mechanism for the antiviral effects of heme oxygenase?Hepatology5218971905201010.1002/hep.2392121105106

40. 

C FillebeenK PantopoulosIron inhibits replication of infectious hepatitis C virus in permissive Huh7.5.1 cellsJ Hepatol53995999201010.1016/j.jhep.2010.04.04420813419

41. 

J ChoiKJ LeeY ZhengAK YamagaMM LaiJH OuReactive oxygen species suppress hepatitis C virus RNA replication in human hepatoma cellsHepatology398189200410.1002/hep.2000114752826

42. 

M YanoM IkedaK AbeOxidative stress induces anti-hepatitis C virus status via the activation of extracellular signal-regulated kinaseHepatology50678688200910.1002/hep.2302619492433

43. 

M KurokiY AriumiM IkedaH DansakoT WakitaN KatoArsenic trioxide inhibits hepatitis C virus RNA replication through modulation of the glutathione redox system and oxidative stressJ Virol8323382348200910.1128/JVI.01840-0819109388

44. 

DP BrazilZZ YangBA HemmingsAdvances in protein kinase B signalling: AKTion on multiple frontsTrends Biochem Sci29233242200410.1016/j.tibs.2004.03.00615130559

45. 

P MannovaL BerettaActivation of the N-Ras-PI3K-Akt-mTOR pathway by hepatitis C virus: control of cell survival and viral replicationJ Virol7987428749200510.1128/JVI.79.14.8742-8749.200515994768

46. 

A StreetA MacdonaldK CrowderM HarrisThe Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascadeJ Biol Chem2791223212241200410.1074/jbc.M31224520014709551

47. 

T PorstmannB GriffithsYL ChungPKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBPOncogene2464656481200516007182

48. 

CY ParkHJ JunT WakitaJH CheongSB HwangHepatitis C virus nonstructural 4B protein modulates sterol regulatory element-binding protein signaling via the AKT pathwayJ Biol Chem28492379246200910.1074/jbc.M80877320019204002

49. 

D Yangxand GabuzdaRegulation of human immunodeficiency virus type 1 infectivity by the ERK mitogen-activated protein kinase signaling pathwayJ Virol7334603466199910074203

50. 

S PleschkaT WolffC EhrhardtInfluenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascadeNat Cell Biol3301305200110.1038/3506009811231581

51. 

Y CaiY LiuX ZhangSuppression of coronavirus replication by inhibition of the MEK signaling pathwayJ Virol81446456200710.1128/JVI.01705-0617079328

52. 

KD SmithJJ MezhirK BickenbachActivated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1J Virol8011101120200610.1128/JVI.80.3.1110-1120.200616414988

53. 

Y ZhengJ LiDL JohnsonJH OuRegulation of hepatitis B virus replication by the ras-mitogen-activated protein kinase signaling pathwayJ Virol7777077712200310.1128/JVI.77.14.7707-7712.200312829809

54. 

H ZhuC LiuInterleukin-1 inhibits hepatitis C virus subgenomic RNA replication by activation of extracellular regulated kinase pathwayJ Virol7754935498200310.1128/JVI.77.9.5493-5498.200312692250

55. 

T MurataM HijikataK ShimotohnoEnhancement of internal ribosome entry site-mediated translation and replication of hepatitis C virus by PD98059Virology340105115200510.1016/j.virol.2005.06.01516005928

56. 

J NdjomouIW ParkY LiuLD MayoJJ HeUp-regulation of hepatitis C virus replication and production by inhibition of MEK/ERK signalingPLoS One4e7498200910.1371/journal.pone.000749819834602

57. 

DI TaiSL TsaiYM ChenActivation of nuclear factor kappaB in hepatitis C virus infection: implications for pathogenesis and hepatocarcinogenesisHepatology31656664200010.1002/hep.51031031610706556

58. 

JK OemC Jackel-CramYP LiHepatitis C virus non-structural protein-2 activates CXCL-8 transcription through NF-kappaBArch Virol153293301200810.1007/s00705-007-1103-118074095

59. 

W LinWL TsaiRX ShaoHepatitis C virus regulates transforming growth factor beta1 production through the generation of reactive oxygen species in a nuclear factor kappaB-dependent mannerGastroenterology138250925182518.e1201010.1053/j.gastro.2010.03.008

60. 

RB RayR SteeleA BasuDistinct functional role of hepatitis C virus core protein on NF-kappaB regulation is linked to genomic variationVirus Res872129200210.1016/S0168-1702(02)00046-112135786

61. 

JC LeeWC ChenSF WuAnti-hepatitis C virus activity of Acacia confusa extract via suppressing cyclooxygenase-2Antiviral Res893542201110.1016/j.antiviral.2010.11.00321075144

62. 

JC LeeCK TsengSF WuFR ChangCC ChiuYC WuSan-Huang-Xie-Xin-Tang extract suppresses hepatitis C virus replication and virus-induced cyclooxygenase-2 expressionJ Viral Hepat18e315e324201110.1111/j.1365-2893.2010.01424.x21692943

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen M, Lee M, Chuang J, Li Y, Ning S, Chen J and Liu Y: Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT. Int J Mol Med 30: 1021-1028, 2012.
APA
Chen, M., Lee, M., Chuang, J., Li, Y., Ning, S., Chen, J., & Liu, Y. (2012). Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT. International Journal of Molecular Medicine, 30, 1021-1028. https://doi.org/10.3892/ijmm.2012.1096
MLA
Chen, M., Lee, M., Chuang, J., Li, Y., Ning, S., Chen, J., Liu, Y."Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT". International Journal of Molecular Medicine 30.5 (2012): 1021-1028.
Chicago
Chen, M., Lee, M., Chuang, J., Li, Y., Ning, S., Chen, J., Liu, Y."Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT". International Journal of Molecular Medicine 30, no. 5 (2012): 1021-1028. https://doi.org/10.3892/ijmm.2012.1096
Copy and paste a formatted citation
x
Spandidos Publications style
Chen M, Lee M, Chuang J, Li Y, Ning S, Chen J and Liu Y: Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT. Int J Mol Med 30: 1021-1028, 2012.
APA
Chen, M., Lee, M., Chuang, J., Li, Y., Ning, S., Chen, J., & Liu, Y. (2012). Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT. International Journal of Molecular Medicine, 30, 1021-1028. https://doi.org/10.3892/ijmm.2012.1096
MLA
Chen, M., Lee, M., Chuang, J., Li, Y., Ning, S., Chen, J., Liu, Y."Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT". International Journal of Molecular Medicine 30.5 (2012): 1021-1028.
Chicago
Chen, M., Lee, M., Chuang, J., Li, Y., Ning, S., Chen, J., Liu, Y."Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT". International Journal of Molecular Medicine 30, no. 5 (2012): 1021-1028. https://doi.org/10.3892/ijmm.2012.1096
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team