Sage weed (Salvia plebeia) extract antagonizes foam cell formation and promotes cholesterol efflux in murine macrophages

VV KunjathoorM FebbraioEA PodrezKJ MooreL AnderssonS KoehnJS RheeR SilversteinHF HoffMW FreemanScavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophagesJ Biol Chem774998249988200210.1074/jbc.M209649200

JS ChoiJY BaeDS KimJ LiJL KimYJ LeeYH KangDietary compound quercitrin dampens VEGF Induction and PPARγ activation in oxidized LDL-exposed murine macrophages: Association with scavenger receptor CD36J Agric Food Chem5813331341201019928818

Y WenDS LeakeLow density lipoprotein undergoes oxidation within lysosomes in cellsCirc Res10013371343200710.1161/CIRCRESAHA.107.15170417446432

N ShibataCK GlassMacrophages, oxysterols and atherosclerosisCirc J7420452051201010.1253/circj.CJ-10-086020838002

NE FreemanAE RusinolM LintonDL HacheyS FazioMS SinenskyD ThewkeAcyl-coenzyme A: cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophagesJ Lipid Res4619331943200510.1194/jlr.M500101-JLR20015995174

A ChawlaWA BoisvertCH LeeBA LaffitteY BarakSB JosephD LiaoL NagyPA EdwardsLK CurtissRM EvansP TontonozA PPARγ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesisMol Cell71611712001

M XuH ZhouKC TanR GuoSW ShiuY WongABCG1 mediated oxidized LDL-derived oxysterol efflux from macrophagesBiochem Biophys Res Commun39013491354200910.1016/j.bbrc.2009.10.15219895785

TE AkiyamaS SakaiG LambertCJ NicolK MatsusueS PimpraleYH LeeM RicoteCK GlassHB Brewer JrFJ GonzalezConditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol effluxMol Cell Biol2226072619200210.1128/MCB.22.8.2607-2619.2002

DE DoveMF LintonS FazioApoE-mediated cholesterol efflux from macrophages: separation of autocrine and paracrine effectsAm J Physiol Cell Physiol288C586C592200510.1152/ajpcell.00210.200415509658

Y ZhaoX ChenH YangL ZhouEU OkoroZ GuoA novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expressionPLoS One6e21453201110.1371/journal.pone.002145321779326

L GuX WengAntioxidant activity and components of Salvia plebeia R.Br. - a Chinese herbFood Chem73299305200110.1016/S0308-8146(00)00300-9

HJ JungYS SongCJ LimEH ParkAnti-inflammatory, anti-angiogenic and anti-nociceptive activities of an ethanol extract of Salvia plebeia R. BrownJ Ethnopharmacol126335360200919715750

JA LimBW YunSH BaekAntioxidative activity and nitrite scavenging ability of methanol extract from Salvia plebeia R. BrKorean J Med Crop Sci151831882007

JS ChoiSW KangJ LiJL KimJY BaeDS KimSY ShinJG JunMH WangYH KangBlockade of oxidized LDL-triggered endothelial apoptosis by quercetin and rutin through differential signaling pathways involving JAK2J Agric Food Chem5720792086200910.1021/jf803390m19196000

OH LowryNJ RosebroughAL FarrRJ RandallProtein measurement with the Folin phenol reagentJ Biol Chem193265275195114907713

YJ JeongYJ ChoiJS ChoiHM KwonSW KangJY BaeSS LeeJS KangSJ HanYH KangAttenuation of monocyte adhesion and oxidised LDL uptake in luteolin-treated human endothelial cells exposed to oxidised LDLBr J Nutr97447457200710.1017/S000711450765789417313705

SW KangJS ChoiJY BaeJ LiDS KimJL KimSY ShinHJ YouHS ParkGE JiYH KangBlockade of vascular angiogenesis by Aspergillus usamii var. shirousamii-transformed Angelicae Gigantis Radix and Zizyphus jujubaNutr Res Pract338200920016695

G EndemannLW StantonKS MaddenCM BryantRT WhiteAA ProtterCD36 is a receptor for oxidized low density lipoproteinJ Biol Chem268118111181619937685021

W LiXM YuanAG OlssonUT BrunkUptake of oxidized LDL by macrophages results in partial lysosomal enzyme inactivation and relocationArterioscler Thromb Vasc Biol18177184199810.1161/01.ATV.18.2.1779484981

MS ChoiWH LeeEY KwonMA KangMK LeeYB ParkSM JeonEffects of soy pinitol on the pro-inflammatory cytokines and scavenger receptors in oxidized low-density lipoprotein-treated THP-1 macrophagesJ Med Food10594601200710.1089/jmf.2006.22018158828

XF JinYH LuDZ WeiZT WangChemical fingerprint and quantitative analysis of Salvia plebeia R.Br. by high-performance liquid chromatographyJ Pharm Biomed Anal481001042008

XJ QuX XiaYS WangMJ SongLL LiuYY XieYN ChengXJ LiuLL QiuL XiangProtective effects of Salvia plebeia compound homoplantaginin on hepatocyte injuryFood Chem Toxicol47171017152009

M OquraM AyaoriY TeraoT HisadaM IizukaS TakiquchiH Uto-KondoE YakushijiK NakayaM SasakiProteasomal inhibition promotes ATP-binding cassette transporter A1 (ABCA1) and ABCG1 expression and cholesterol efflux from macrophages in vitro and in vivoArterioscler Thromb Vasc Biol3119801987201110.1161/ATVBAHA.111.22847821817095

YC LinCM HungJC TsaiJC LeeYL ChenCW WeiJY KaoTD WayHispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK)J Agric Food Chem5895119517201010.1021/jf101953320698539

L HeY WuL LinJ WangY WuY ChenZ YiM LiuX PangHispidulin, a small flavonoid molecule, suppresses the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2-mediated PI3K/Akt/mTOR signaling pathwayCancer Sci102219225201110.1111/j.1349-7006.2010.01778.x

H Uto-KondoM AyaoriM OguraK NakayaM ItoA SuzukiS TakiguchiE YakushijiY TeraoH OzasaCoffee consumption enhances high-density lipoprotein-mediated cholesterol efflux in macrophagesCirc Res106779787201010.1161/CIRCRESAHA.109.20661520075335

AR TallCholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteinsJ Intern Med263256273200810.1111/j.1365-2796.2007.01898.x18271871

J JiangZC MoK YinGJ ZhaoYC LvXP OuyangZS JiangY FuCK TangEpigallocatechin-3-gallate prevents TNF-α-induced NF-κB activation thereby upregulating ABCA1 via the Nrf2/Keap1 pathway in macrophage foam cellsInt J Mol Med299469562012