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November 2012 Volume 30 Issue 5

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miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells

  • Authors:
    • Haien Zhao
    • Mingjun Guo
    • Guangyi Zhao
    • Qiong Ma
    • Baoan Ma
    • Xiuchun Qiu
    • Qingyu Fan
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1013-1020
    |
    Published online on: August 24, 2012
       https://doi.org/10.3892/ijmm.2012.1111
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Abstract

Osteosarcoma is the most common primary malignancy of bone in teenagers and approximately 30% of patients develop lung metastasis, which is the leading cause of mortality. Recent studies suggest that the Ezrin protein is correlated with the metastatic potential of several malignant tumors. In our study, ectopic overexpression of miR-183 repressed the expression levels of Ezrin and significantly inhibited the motility and invasion of osteosarcoma cells. This suggests that miR-183 may possibly play a tumor suppressor role in the metastasis of osteosarcoma by downregulating Ezrin expression levels. These findings show that through inhibition of Ezrin expression levels, miR-183 is significantly involved in cell migration and invasion of osteosarcoma.
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1. 

SM BentzenHS PoulsenS KaaeOM JensenH JohansenHT MouridsenPrognostic factors in osteosarcomas. A regression analysisCancer62194202198810.1002/1097-0142(19880701)62:1%3C194::AID-CNCR2820620129%3E3.0.CO;2-83164231

2. 

AM DavisRS BellPJ GoodwinPrognostic factors in osteosarcoma: a critical reviewJ Clin Oncol1242343119948113851

3. 

HJ MankinFJ HornicekAE RosenbergDC HarmonMC GebhardtSurvival data for 648 patients with osteosarcoma treated at one institutionClin Orthop Relat Res429286291200410.1097/01.blo.0000145991.65770.e615577500

4. 

V AmbrosRC LeeIdentification of microRNAs and other tiny noncoding RNAs by cDNA cloningMethods Mol Biol265131158200415103073

5. 

RS PillaiSN BhattacharyyaW FilipowiczRepression of protein synthesis by miRNAs: how many mechanisms?Trends Cell Biol17118126200710.1016/j.tcb.2006.12.00717197185

6. 

DP BartelMicroRNAs: genomics, biogenesis, mechanism and functionCell116281297200410.1016/S0092-8674(04)00045-514744438

7. 

C CaldasJD BrentonSizing up miRNAs as cancer genesNat Med11712714200510.1038/nm0705-71216015356

8. 

GA CalinCM CroceMicroRNA signatures in human cancersNat Rev Cancer6857866200610.1038/nrc199717060945

9. 

B KefasJ GodlewskiL ComeauY LiR AbounaderM HawkinsonmicroRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is downregulated in glioblastomaCancer Res6835663572200810.1158/0008-5472.CAN-07-663918483236

10. 

Y LadeiroG CouchyC BalabaudP Bioulac-SageL PelletierJ Zucman-RossiMicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutationsHepatology4719551963200810.1002/hep.2225618433021

11. 

K MotoyamaH InoueY TakatsunoOver- and under-expressed microRNAs in human colorectal cancerInt J Oncol3410691075200919287964

12. 

X AgirreA Jimenez-VelascoE San Jose-EnerizL GarateE BandresDown-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growthMol Cancer Res618301840200810.1158/1541-7786.MCR-08-016719074828

13. 

MD MattieCC BenzJ BowersK SensingerOptimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsiesMol Cancer524200610.1186/1476-4598-5-24

14. 

G WangW MaoS ZhengMicroRNA-183 regulates Ezrin expression in lung cancer cellsFEBS Lett58236633668200810.1016/j.febslet.2008.09.05118840437

15. 

X ChenTT YangW WangHH SunEstablishment and characterization of human osteosarcoma cell lines with different pulmonary metastatic potentialsCytotechnology613744200910.1007/s10616-009-9239-320016965

16. 

E BandresE CubedoX AgirreR MalumbresR ZarateIdentification by real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissuesMol Cancer529200610.1186/1476-4598-5-2916854228

17. 

AJ LoweryN MillerRM DwyerMJ KerinDysregulated miR-183 inhibits migration in breast cancer cellsBMC Cancer10502201010.1186/1471-2407-10-50220858276

18. 

JG DoenchPA SharpSpecificity of microRNA target selection in translational repressionGenes Dev18504511200410.1101/gad.118440415014042

19. 

SF TavazoieC AlarconT OskarssonEndogenous human microRNAs that suppress breast cancer metastasisNature451147152200810.1038/nature0648718185580

20. 

KR LeiteJM Sousa-CanavezST ReisAH TomiyamaLH Camara-LopesA SañudoAA AntunesM SrouqiChange in expression of miR-let7c, miR-100 and miR-218 from high grade localized prostate cancer to metastasisUrol Oncol29265269201110.1016/j.urolonc.2009.02.00219372056

21. 

GK ScottA GogaD BhaumikCE BergerCS SullivanCC BenzCoordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA, miR-125a or miR-125bJ Biol Chem28214791486200710.1074/jbc.M60938320017110380

22. 

MS KumarJ LuKL MercerTR GolubT JacksImpaired microRNA processing enhances cellular transformation and tumorigenesisNat Genet39673677200710.1038/ng200317401365

23. 

J MazarD DeBlasioSS GovindarajanS ZhangRJ PereraEpigenetic regulation of microRNA-375 and its role in melanoma development in humansFEBS Lett58524672476201110.1016/j.febslet.2011.06.02521723283

24. 

L WuC CaiX WangM LiuX LiH TangMicroRNA-142-3p, a new regulator of RAC1, suppresses the migration and invasion of hepatocellular carcinoma cellsFEBS Lett58513221330201110.1016/j.febslet.2011.03.06721482222

25. 

S TanR LiK DingPE LobieT ZhumiR-198 inhibits migration and invasion of hepatocellular carcinoma cells by targeting the HGF/c-MET pathwayFEBS Lett58522292234201110.1016/j.febslet.2011.05.04221658389

26. 

G LiC LunaJ QiuDL EpsteinP GonzalezTargeting of integrin beta1 and kinesin 2alpha by microRNA 183J Biol Chem28554615471201010.1074/jbc.M109.03712719940135

27. 

A KrekD GrunMN PoyR WolfL RosenbergEJ EpsteinP MacMenaminI da PiedadeKC GunsalusM StoffelN RajewskyCombinatorial microRNA target predictionsNat Genet37495500200510.1038/ng1536

28. 

Y YuJ KhanC KhannaL HelmanPS MeltzerG MerlinomExpression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six21 as key metastatic regulatorsNat Med10175181200410.1038/nm96614704789

29. 

P MangeatC RoyM MartinERM proteins in cell adhesion and membrane dynamicsTrends Cell Biol9187192199910.1016/S0962-8924(99)01544-510322453

30. 

A BretscherK EdwardsRG FehonERM proteins and merlin: integrators at the cell cortexNat Rev Mol Cell Biol3586599200210.1038/nrm88212154370

31. 

JW WangSY PengJT LiY WangZP ZhangY ChengDQ ChengWH WengXS WuXZ FeiIdentification of metastasis-associated proteins involved in gallbladder carcinoma metastasis by proteomic analysis and functional exploration of chloride intracellular channel 1Cancer Lett2817181200910.1016/j.canlet.2009.02.020

32. 

KW HunterEzrin, a key component in tumor metastasisTrends Mol Med10201204200410.1016/j.molmed.2004.03.00115121044

33. 

WH WengJ AhlenK AstromWO LuiC LarssonPrognostic impact of immunohistochemical expression of ezrin in highly malignant soft tissue sarcomasClin Cancer Res1161986204200510.1158/1078-0432.CCR-05-054816144921

34. 

C KhannaX WanS BoseR CassadayO OlomuA MendozaC YeungR GorlickSM HewittLJ HelmanThe membrane cytoskeleton linker ezrin is necessary for osteosarcoma metastasisNat Med10182186200410.1038/nm98214704791

35. 

MS KimWS SongWH ChoSY LeeDG JeonEzrin expression predicts survival in stage IIB osteosarcomasClin Orthop Relat Res459229236200710.1097/BLO.0b013e3180413dbf17353802

36. 

S Xu-DongS ZanZ Shui-ErT Li-NaY Wen-XiL FengY YangExpression of ezrin correlates with lung metastasis in Chinese patients with osteosarcomaClin Invest Med32E180E188200919331807

37. 

YF WangJN ShenExpression change of ezrin as a prognostic factor in primary osteosarcomaMed Oncol28S636S643201110.1007/s12032-010-9684-z20859706

38. 

HW KangF WangmiR-20a promotes migration and invasion by regulating TNKS2 in human cervical cancer cellsFEBS Lett586897904201210.1016/j.febslet.2012.02.02022449978

39. 

L WuH LiCY JiaW ChengMicroRNA-223 regulates FOXO1 expression and cell proliferationFEBS Lett58610381043201210.1016/j.febslet.2012.02.05022569260

40. 

N HuangJ LinJ RuanN SuMiR-219-5p inhibits hepatocellular carcinoma cell proliferation by targeting glypican-3FEBS Lett586884891201210.1016/j.febslet.2012.02.01722449976

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Copy and paste a formatted citation
Spandidos Publications style
Zhao H, Guo M, Zhao G, Ma Q, Ma B, Qiu X and Fan Q: miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells. Int J Mol Med 30: 1013-1020, 2012.
APA
Zhao, H., Guo, M., Zhao, G., Ma, Q., Ma, B., Qiu, X., & Fan, Q. (2012). miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells. International Journal of Molecular Medicine, 30, 1013-1020. https://doi.org/10.3892/ijmm.2012.1111
MLA
Zhao, H., Guo, M., Zhao, G., Ma, Q., Ma, B., Qiu, X., Fan, Q."miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells". International Journal of Molecular Medicine 30.5 (2012): 1013-1020.
Chicago
Zhao, H., Guo, M., Zhao, G., Ma, Q., Ma, B., Qiu, X., Fan, Q."miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells". International Journal of Molecular Medicine 30, no. 5 (2012): 1013-1020. https://doi.org/10.3892/ijmm.2012.1111
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao H, Guo M, Zhao G, Ma Q, Ma B, Qiu X and Fan Q: miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells. Int J Mol Med 30: 1013-1020, 2012.
APA
Zhao, H., Guo, M., Zhao, G., Ma, Q., Ma, B., Qiu, X., & Fan, Q. (2012). miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells. International Journal of Molecular Medicine, 30, 1013-1020. https://doi.org/10.3892/ijmm.2012.1111
MLA
Zhao, H., Guo, M., Zhao, G., Ma, Q., Ma, B., Qiu, X., Fan, Q."miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells". International Journal of Molecular Medicine 30.5 (2012): 1013-1020.
Chicago
Zhao, H., Guo, M., Zhao, G., Ma, Q., Ma, B., Qiu, X., Fan, Q."miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells". International Journal of Molecular Medicine 30, no. 5 (2012): 1013-1020. https://doi.org/10.3892/ijmm.2012.1111
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