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International Journal of Molecular Medicine
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November 2012 Volume 30 Issue 5

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Article

Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo

  • Authors:
    • Hui Li
    • Weijue Xu
    • Yimin Huang
    • Xiong Huang
    • Lingcang Xu
    • Zhibao Lv
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Surgery, Children's Hospital of Shanghai, Shanghai Jiaotong University, Shanghai 200040, P.R. China
  • Pages: 1081-1086
    |
    Published online on: September 6, 2012
       https://doi.org/10.3892/ijmm.2012.1118
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Abstract

Neuroblastoma (NB) is a type of tumor usually found in children under 5 years of age, which originates from lesions in the nervous system and has fast growth and early transformation characteristics. Similar to other cancer types, some typical tumor suppressor genes (TSGs), such as P53 and CHD5 are silenced in NB because of high methylation at promoter zones. In the present study, our results showed that genistein, an element found in soy, is an epigenetic modifier able to decrease hypermethylation levels of CHD5, and enhances the expression of CHD5 as well as p53, possibly contributing to inhibition of NB growth in vivo and tumor microvessel formation. Furthermore, genistein acts as a DNA methyltransferase (DNMT) inhibitor to significantly decrease the expression of DNMT3b. Our study indicates that genistein plays an important role in inhibiting NB growth in vivo, probably preventing tumorigenesis risk as a kind of therapeutic agent for NB treatment in the future.
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1. 

M BerdascoS RoperoF SetienEpigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and gliomaProc Natl Acad Sci USA1062183021835200910.1073/pnas.090683110620018718

2. 

A DecockM OngenaertJ VandesompeleF SpelemanNeuroblastoma epigenetics: from candidate gene approaches to genome-wide screeningsEpigenetics6962970201110.4161/epi.6.8.1651621725203

3. 

TD HowardSM HoL ZhangEpigenetic changes with dietary soy in cynomolgus monkeysPloS One6e26791201110.1371/journal.pone.002679122046358

4. 

Y ZhangH ChenGenistein, an epigenome modifier during cancer preventionEpigenetics6888891201110.4161/epi.6.7.1631521610327

5. 

SI KhanP AumsuwanIA KhanLA WalkerAK DasmahapatraEpigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenomeChem Res Toxicol256173201110.1021/tx200378c21992498

6. 

H MatsukuraK AisakiK IgarashiGenistein promotes DNA demethylation of the steroidogenic factor 1 (SF-1) promoter in endometrial stromal cellsBiochem Biophys Res Commun412366372201110.1016/j.bbrc.2011.07.10421821006

7. 

N SatoN YamakawaM MasudaK SudoI HatadaM MuramatsuGenome-wide DNA methylation analysis reveals phytoestrogen modification of promoter methylation patterns during embryonic stem cell differentiationPloS One6e19278201110.1371/journal.pone.001927821559447

8. 

S MajidAA DarV ShahryariGenistein reverses hyper-methylation and induces active histone modifications in tumor suppressor gene B-Cell translocation gene 3 in prostate cancerCancer1166676201019885928

9. 

M EstellerCpG island hypermethylation and tumor suppressor genes: a booming present, a brighter futureOncogene2154275440200210.1038/sj.onc.120560012154405

10. 

MZ FangD ChenY SunZ JinJK ChristmanCS YangReversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soyClin Cancer Res1170337041200510.1158/1078-0432.CCR-05-040616203797

11. 

MZ FangZ JinY WangPromoter hypermethylation and inactivation of O(6)-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell linesInt J Oncol26615622200515703815

12. 

A BagchiC PapazogluY WuCHD5 is a tumor suppressor at human 1p36Cell128459475200710.1016/j.cell.2006.11.05217289567

13. 

T FujitaJ IgarashiER OkawaCHD5, a tumor suppressor gene deleted from 1p36.31 in neuroblastomasJ Natl Cancer Inst100940949200810.1093/jnci/djn17618577749

14. 

DH HanMS DenisonH TachibanaK YamadaRelationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoidsBiosci Biotechnol Biochem6614791487200210.1271/bbb.66.147912224631

15. 

HC ZhaoR QinXX ChenMicrovessel density is a prognostic marker of human gastric cancerWorld J Gastroenterol1275987603200617171787

16. 

B HammondBS KatzenellenbogenN KrauthammerJ McConnellEstrogenic activity of the insecticide chlordecone (Kepone) and interaction with uterine estrogen receptorsProc Natl Acad Sci USA7666416645197910.1073/pnas.76.12.664193289

17. 

JA McLachlanKS KorachRR NewboldGH DegenDiethylstilbestrol and other estrogens in the environmentFundam Appl Toxicol4686691198410.1016/0272-0590(84)90089-76510599

18. 

CL Hughes JrPhytochemical mimicry of reproductive hormones and modulation of herbivore fertility by phytoestrogensEnviron Health Perspect78171174198810.1289/ehp.88781713203635

19. 

T ColbornFS vom SaalAM SotoDevelopmental effects of endocrine-disrupting chemicals in wildlife and humansEnviron Health Perspect101378384199310.1289/ehp.931013788080506

20. 

SC NagelFS vom SaalKA ThayerMG DharM BoechlerWV WelshonsRelative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenolEnviron Health Perspect1057076199710.1289/ehp.97105709074884

21. 

WW LeavittDM MeismerSexual development altered by non-steroidal oestrogensNature218181182196810.1038/218181a05689495

22. 

AM SotoC SonnenscheinKL ChungMF FernandezN OleaFO SerranoThe E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutantsEnviron Health Perspect103Suppl 7113122199510.1289/ehp.95103s71138593856

23. 

J ZhengX XiaoJ LiuS ZhengQ YinY YuGrowth-promoting effect of environmental endocrine disruptors on human neuroblastoma SK-N-SH cellsEnviron Toxicol Pharmacol24189193200710.1016/j.etap.2007.05.00321783809

24. 

H AdlercreutzPhytoestrogens: epidemiology and a possible role in cancer protectionEnviron Health Perspect103Suppl 7103112199510.1289/ehp.95103s71038593855

25. 

KD SetchellA CassidyDietary isoflavones: biological effects and relevance to human healthJ Nutr129S758S767199910082786

26. 

T FotsisM PepperH AdlercreutzGenistein, a dietary-derived inhibitor of in vitro angiogenesisProc Natl Acad Sci USA9026902694199310.1073/pnas.90.7.26907681986

27. 

L StraussR SanttiN SaarinenT StrengS JoshiS MakelaDietary phytoestrogens and their role in hormonally dependent diseaseToxicol Lett102–103349354199810022277

28. 

MA MoyadSoy, disease prevention, and prostate cancerSemin Urol Oncol1797102199910332923

29. 

ER OkawaT GotohJ ManneExpression and sequence analysis of candidates for the 1p36.31 tumor suppressor gene deleted in neuroblastomasOncogene27803810200810.1038/sj.onc.121067517667943

30. 

NH KimHS KimNG Kimp53 and microRNA-34 are suppressors of canonical Wnt signalingSci Signal4ra71201122045851

31. 

J TostDNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarkerMol Biotechnol447181201010.1007/s12033-009-9216-2

32. 

M FangD ChenCS YangDietary polyphenols may affect DNA methylationJ Nutr137S223S2282007

33. 

Z WangH ChenGenistein increases gene expression by demethylation of WNT5a promoter in colon cancer cell line SW1116Anticancer Res3045374545201021115903

34. 

SH SongSW HanYJ BangEpigenetic-based therapies in cancer: progress to dateDrugs7123912403201110.2165/11596690-000000000-0000022141383

35. 

JM FoulksKM ParnellRN NixEpigenetic drug discovery: targeting DNA methyltransferasesJ Biomolecular Screen17217201110.1177/1087057111421212

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Copy and paste a formatted citation
Spandidos Publications style
Li H, Xu W, Huang Y, Huang X, Xu L and Lv Z: Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo. Int J Mol Med 30: 1081-1086, 2012.
APA
Li, H., Xu, W., Huang, Y., Huang, X., Xu, L., & Lv, Z. (2012). Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo. International Journal of Molecular Medicine, 30, 1081-1086. https://doi.org/10.3892/ijmm.2012.1118
MLA
Li, H., Xu, W., Huang, Y., Huang, X., Xu, L., Lv, Z."Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo". International Journal of Molecular Medicine 30.5 (2012): 1081-1086.
Chicago
Li, H., Xu, W., Huang, Y., Huang, X., Xu, L., Lv, Z."Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo". International Journal of Molecular Medicine 30, no. 5 (2012): 1081-1086. https://doi.org/10.3892/ijmm.2012.1118
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Xu W, Huang Y, Huang X, Xu L and Lv Z: Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo. Int J Mol Med 30: 1081-1086, 2012.
APA
Li, H., Xu, W., Huang, Y., Huang, X., Xu, L., & Lv, Z. (2012). Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo. International Journal of Molecular Medicine, 30, 1081-1086. https://doi.org/10.3892/ijmm.2012.1118
MLA
Li, H., Xu, W., Huang, Y., Huang, X., Xu, L., Lv, Z."Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo". International Journal of Molecular Medicine 30.5 (2012): 1081-1086.
Chicago
Li, H., Xu, W., Huang, Y., Huang, X., Xu, L., Lv, Z."Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo". International Journal of Molecular Medicine 30, no. 5 (2012): 1081-1086. https://doi.org/10.3892/ijmm.2012.1118
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